Hydroxychloroquine for generalized granuloma annulare: 35% response rate in a retrospective case series of 26 patients

Hrin, Matthew L.; Feldman, Steven R.; Huang, William W.

doi:10.1016/j.jaad.2021.06.867

Cited by 7 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas localized GA tends to be self-limited, other subtypes, particularly generalized GA, can have high recurrence rates. Many treatments have been investigated for generalized GA with inconsistent results and varied side efects, including topical and intralesional steroids, topical immunomodulators (tacrolimus), antimicrobials (doxycycline, dapsone, and hydroxychloroquine), phototherapy, TNF-alpha inhibitors, and oral vitamin E [19][20][21]. Of the patients in our cohort who pursued these therapies, namely, intralesional steroids or topical immunomodulators, there was no clear association with a particular outcome.…”

Section: Discussionmentioning

confidence: 82%

Characterizing Granuloma Annulare in 73 Pediatric Patients

Stolarczyk,

Bawany,

Hernandez

et al. 2023

Dermatology Research and Practice

View full text Add to dashboard Cite

Background. Granuloma annulare (GA) is a common, benign, idiopathic inflammatory dermatosis. Aside from case reports and small studies, there are limited data about the characteristics of GA in children. Objective. This study aimed to better characterize the epidemiologic and clinical features, triggering factors, disease associations, and outcomes of GA in the pediatric population. Methods. We conducted a retrospective study of 73 pediatric patients diagnosed with GA at the University of Rochester Medical Center over a 7-year period. Results. The most common subtype was localized GA (71.2%, n = 52), followed by subcutaneous (also known as “deep GA”; 16.4%, n = 12) and generalized (12.3%, n = 9) subtypes. Over 90% of patients had idiopathic GA, with the remaining patients reporting viral infection or trauma as triggers. Half of the patients studied had comorbid conditions, most frequently atopic dermatitis (17.8%, n = 13), obesity (9.59%, n = 7), asthma (6.85%, n = 5), and allergic rhinitis (6.85%, n = 5). The median duration of the disease was 11.00 months (interquartile range (IQR) 15.75 months); generalized GA had the shortest duration (median 10.00 months, IQR 15.50 months), while subcutaneous GA had the longest duration (median 12.00 months and IQR 29.00 months). Although recurrence rates for subcutaneous and generalized GA were high at 45.5% and 33.3%, respectively, most patients achieved clearance or improvement with treatment. Conclusion. Most cases of GA in our study were idiopathic, with no clear differences between GA subtypes and associated comorbidities. Topical steroids were the most prescribed treatment with mixed efficacy.

show abstract

Section: Discussionmentioning

confidence: 82%

Characterizing Granuloma Annulare in 73 Pediatric Patients

Stolarczyk,

Bawany,

Hernandez

et al. 2023

Dermatology Research and Practice

View full text Add to dashboard Cite

show abstract

“…Całkowita remisja zmian dotyczyła natomiast 24% chorych stosujących miejscowe glikokortykosteroidy, 14% chorych leczo-Dermatology Review/Przegląd Dermatologiczny 2022/5 hydroxychloroquine at the dose of 400 mg daily for a period of 10 months. The treatment results were not spectacular, as only 35% of patients achieved clinical improvement [11]. In the case of chronic and recurrent granuloma annulare, biological drugs from the anti-TNF group seem to be an effective therapeutic option, in particular adalimumab [12], etanercept [13] and infliximab [14].…”

Section: Discussionmentioning

confidence: 99%

“…zakwalifikowano 26 pacjentów z uogólnioną postacią ziarniniaka obrączkowatego, u których włączono do leczenia hydroksychlorochinę w dawce 400 mg dziennie przez 10 miesięcy. Wyniki terapii nie były spektakularne, ponieważ tylko 35% pacjentów osiągnęło poprawę kliniczną [11]. W przypadku przewlekłego i nawracającego ziarniniaka obrączkowatego skuteczną opcją terapeutyczną wydają się leki biologiczne z grupy anty-TNF, zwłaszcza adalimumab [12], etanercept [13] oraz infliksymab [14].…”

Section: Discussionunclassified

Granuloma annulare – diagnostic challenges

Cichoń¹,

Placek²

2022

View full text Add to dashboard Cite

Introduction: Granuloma annulare is a chronic, inflammatory skin disease occurring mainly in young people, much more often in women. Skin lesions may be solitary or diffuse. They are usually located on the backs of the hands or feet and around the ankles. The etiology of the disease remains unknown. A relationship between granuloma annulare and the occurrence of type 2 diabetes, hyperlipidemia or autoimmune diseases is postulated. Case report: We present the case of a 55-year-old woman with bilateral skin lesions on extensor parts of her elbows, who for over 15 years remained without an accurate diagnosis. Clinically, the lesions corresponded to persistent and haughty erythema. Finally, on the basis of histological examination, granuloma annulare was diagnosed. Conclusions: In special cases, granuloma annulare may be a dermatosis that is difficult to diagnose solely on the basis of the clinical presentation. A histological examination are then necessary.

show abstract

mentioning

confidence: 91%

“…Our study suggests that while topical and UVB treatment yield low response rates, HCQ and adalimumab are promising therapies. Previous retrospective studies have reported varying rates of improvement of GA with HCQ (9/26, 35%; 9/14, 64%), 2 and a small retrospective study of 7 patients reported improvement in all patients treated with adalimumab. 3 The prevalence of T2DM and hypothyroidism in our study were higher than previous retrospective studies of patient populations in the United States and Europe, with a lower prevalence of malignancy.…”

mentioning

confidence: 91%