Hydroxyapatite Synthesis from Fish Bones: Atlantic Salmon (Salmon Salar)

Kömür, Baran; Altun, Esra; Aydoğdu, Mehmet Onur; Bılgıç, D.; Gökçe, Hasan; Ekren, Nazmi; Salman, Serdar; İnan, Ahmet Talat; Oktar, Faik N.; Gündüz, Oğuzhan

doi:10.12693/aphyspola.131.400

Cited by 18 publications

(5 citation statements)

References 12 publications

(8 reference statements)

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“…Fish bones, which are made of 60% calcium orthophosphate, [36] can be refined through heat treatment to achieve a desired phase composition, such as HA or TCP (Figure 2a,b). [82][83][84][85][86][87][88][89][90] The pristine or treated fish bone powders have been used to fabricate porous HA [91] and porous biphasic calcium phosphate scaffolds. [92] They can also be incorporated into hydrogels, such as GelMA, [93] and alloys, such as Mg-Zn, [94] to form composites.…”

Section: Calcium Phosphate and Collagen From Fish Residuesmentioning

confidence: 99%

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Putra

Zhou

Zadpoor

2023

Adv Healthcare Materials

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The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for sustainable development. Although tissue engineering has rapidly developed, the challenges associated with fulfilling the increasing demand for bone substitutes and implants remain unresolved, particularly as the global population ages. This review provides an overview of waste materials, such as eggshells, seashells, fish residues, and agricultural biomass, that can be transformed into biomaterials for bone tissue engineering. While the development of recycled metals is in its early stages, we highlight the use of probiotics and renewable polymers to improve the biofunctionalities of bone implants. Despite the advances of additive manufacturing (AM), studies on AM waste‐derived bone‐substitutes are limited. It is foreseeable that AM technologies can provide a more sustainable alternative to manufacturing biomaterials and implants. The preliminary results of eggshell and seashell‐derived calcium phosphate and rice husk ash‐derived silica will likely pave the way for more advanced applications of AM waste‐derived biomaterials for sustainably addressing several unmet clinical applications.This article is protected by copyright. All rights reserved

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Section: Calcium Phosphate and Collagen From Fish Residuesmentioning

confidence: 99%

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Putra

Zhou

Zadpoor

2023

Adv Healthcare Materials

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“…Some of these extraction processes include calcination methods, alkaline hydrolysis, precipitation, hydrothermal or a combination of these techniques [ 16 ]. HA extracted from animal by-products has promising potential for various biomedical applications because it is biocompatible and bioactive [ 17 ]. Fish bones are an alternative that can be used to overcome the shortcomings of PMMA.…”

Section: Introductionmentioning

confidence: 99%

PMMA bone cement with L -arginine/nano fish bone nanocomplex for apatite formation

Khoman,

Kalijaga,

Aisah

et al. 2024

R. Soc. Open Sci.

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Bone cement is one of the materials used in orthopaedics that serves various functions, such as binding bone implants, replacing damaged bones and filling spaces within bones. Various materials have been used to synthesize bone cement, and one promising material for further research is fish bone waste-based bone cement. This study investigates the potential of fish bone waste-based bone cement by incorporating nano fish bone (NFB) and L -arginine ( L -Arg) protein into polymethyl methacrylate (PMMA) to examine apatite growth. NFB derived from the Salmo salar fish positively influences osteoblast cell proliferation and differentiation, while L-Arg enhances biocompatibility and antibiotic properties. The NFB/L-Arg combination holds promise in accelerating new bone formation and cell growth, both of which are crucial for fracture healing and bone remodelling. Tensile strength tests reveal the superior performance of BC-PMMA-1-NFB/L-Arg (36.11 MPa) compared with commercial PMMA (32 MPa). Immersion tests with simulated body fluid (SBF) solution for 7 days reveal accelerated apatite layer formation, emphasizing the potential benefits of NFB/ L -Arg in bone cement applications.

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“…However, there are many considerations to be taken into account for heat treatment method such as heating profile of the raw material and optimum calcination temperature. There are many studies had been reported on the extraction of HAp using fish as an initial material [27][28][29][30], but none of the studies were carried out on the species of spotted sardinella (Amblygastersirm). The discovery of this new species of material for HAp extraction is needed to fulfil the gap of this research field.…”

Section: Introductionmentioning

confidence: 99%

Correlation of heating profile with calcination temperature for the extraction of nano hydroxyapatite (Nano-HAp) derived from bone

Hasan

Ghazali

Mohtar

2021

JMES

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Bone is one of the major sources of hydroxyapatite (HAp) in the form of calcium phosphate. The increasing demand for HAp has brought much interest in research line to find the best method for its production either synthetically or naturally. Calcination of natural bone is a common heat treatment method for production of HAp. However, the optimum temperature of calcination depends on source and heating profile of the bone. Therefore, this study aimed to determine heating profile and the optimum calcination temperature of Nano-hyroxyapatite (Nano-HAp) extracted from spotted sardinella (Amblygaster sirm) bone. Characterization of Nano-HAp was carried out using thermogravimetric analysis (TGA), chromameter and X-ray diffraction (XRD) spectroscopy. The composition of protein, ash, moisture and lipid content of raw bone (RB) were 1.08%, 50.98%, 10.47% and 3.78%, respectively. Results demonstrated that the optimum temperature for extracted nano-hydroxyapatite (HAp-1) was 700°C based on yield percentage (55%) and colour changes value (∆E=18). Heating profile of raw bone demonstrated the highest reduction of weight loss percentage (320°C to 610°C=36%); which determined the melting point of the bone that acted as a supporting analysis for calcination. XRD confirmed the crystallinity phase of HAp-1 particle similar to the standard peak of HAp, (PDF No: 1-1008) and comparable with the standard HAp. Based on the heating profile and colour changes value, the findings demonstrated that the calcination of HAp from bone of spotted sardinella (Amblygaster sirm) could be carried out at an optimum temperature of 700°C. Overall findings have suggested that the optimum calcination temperature obtainedmay contribute to the development of optimal method for the extraction of HAp via heat treatment process with different fish species.

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Hydroxyapatite Synthesis from Fish Bones: Atlantic Salmon (Salmon Salar)

Cited by 18 publications

References 12 publications

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

PMMA bone cement with L -arginine/nano fish bone nanocomplex for apatite formation

Correlation of heating profile with calcination temperature for the extraction of nano hydroxyapatite (Nano-HAp) derived from bone

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