Hydroxyapatite/hyperbranched polyitaconic acid/chitosan composite scaffold for bone tissue engineering

Abstract

In this study, a promising modified composite scaffold (hydroxyapatite/hyperbranched polyitaconic acid/chitosan) was synthesized for bone tissue engineering. Novel hyperbranched polyitaconic acid was prepared through the polymerization of itaconic acid using reversible addition fragmentation chain transfer using a macro‐RAFT agent. The chemical structure of the prepared hyperbranched polyitaconic acid was characterized by FTIR and 1HNMR and was subsequently embedded into hydroxyapatite/chitosan composite. The obtained modified composite scaffold was evaluated by characterizing its porosity, mechanical properties, bioactivity and cytotoxicity. The results showed that the modified composite scaffold had higher mechanical strength (i.e., 0.56 ± 0.03 MPa) in comparison to chitosan/hydroxyapatite scaffold only (i.e., 0.31 ± 0.01 MPa) and also showed higher bioactivity. In addition, the modified composite scaffold (HAP/HBP‐RAFT‐PI/CS) showed anticancer properties and enhanced human skin fibroblasts proliferation.

Electron beam radiation constructed and improved bone repairing performance based on hierarchical thermoplastic polyurethane/graphene oxide/hydroxyapatite hot melt adhesive with high flow ductility

“…Hydroxyapatite (HAP) is extensively utilized in bone tissue regeneration engineering due to its ability to achieve chemical bonding at the interface, excellent biocompatibility, and remarkable bioactivity. The strong adhesion formed by chemical bonds between HAP and surrounding bone tissue provides mechanical stability and promotes long‐term integration between the graft material and host tissue 27 . The composition of HAP is very similar to that of natural bone, ensuring that is well tolerated and did not cause adverse reactions or immune responses when implanted 28 .…”