Hydroxyapatite grafting promotes new bone formation and osseointegration of smooth titanium implants

Allegrini, Sérgio; Rumpel, Elisabeth; Kauschke, Ellen; Fanghänel, Jochen; König, Bruno

doi:10.1016/j.aanat.2005.08.019

Cited by 47 publications

(32 citation statements)

References 35 publications

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“…Accelerated osseointegration and increased bone-implant contact can be achieved by coating implants with HA layers [19]. HA is present in human hard tissues in the form of rod-like structures.…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering

Fan

Wang

et al. 2014

Carbon

163

110

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Section: Introductionmentioning

confidence: 99%

One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering

Fan

Wang

et al. 2014

Carbon

163

110

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“…Scaffolds made from nanocomposite fibres with gelatine as the matrix and HA nanocrystals showed improved bone-derived cellular activity compared to pure gelatine scaffolds [26], and better attachment and proliferation of osteoblasts than conventional microcomposite gelatine/HA scaffolds [32]. Hydroxyapatite seems to promote osteoconduction [33], growth of human mesenchymal stem cells and osteogenic differentiation [34]. Du et al [35] concluded that HA/collagen nanocomposites are the ideal bone-mimic materials, following a process of implant degradation and bone substitution in vivo which was reminiscent of bone modelling.…”

Section: Introductionmentioning

confidence: 99%

Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts

et al. 2007

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Gelatine gels and gelatine/elastin gels have been prepared to be used in tissue engineered vascular grafts. Optical microscopy and AFM revealed that the gelatine formed nanofibrils as in soft collagen tissues. The gelatine/elastin gels were nanocomposites with flat elastin nanodomains embedded in the gelatine matrix mimicking the structure of the tunica media in arteries. Gelatine/"hydroxyapatite" nanocomposites were prepared with the in situ production of "hydroxyapatite" in solution. AFM revealed "hydroxyapatite" solid nanoparticles of about 20 nm size embedded in the gelatine matrix which formed a hierarchical structure similar to that of the collagen matrix in bone. The application of a magnetic field of 9.4 T resulted in the elongation and orientation of gelatine particles and orientation of gelatine microfibrils in a direction perpendicular to that of the magnetic field.3

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“…HA incorporation is widely used in the dental field to aid implant osseointegration 10,29 . In this work we observed that incorporation of HA increased adhesion to smoother surfaces (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Electrodeposited silk coatings for bone implants

et al. 2014

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The aim of this study was to characterize the mechanical properties and drug elution features of silk protein-based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1 to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment.

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Hydroxyapatite grafting promotes new bone formation and osseointegration of smooth titanium implants

Cited by 47 publications

References 35 publications

One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering

One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering

Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts

Electrodeposited silk coatings for bone implants

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