Electrodeposited silk coatings for bone implants

Abstract

The aim of this study was to characterize the mechanical properties and drug elution features of silk protein-based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1 to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment.

Evaluation of silk fibroin electrogel coating for zirconia material surface

“…According to results reported in vivo, the combination of acid etching and sandblasting can accelerate bone regeneration 36) . Elia et al 37) reported that a higher adhesive strength was obtained on a rougher surface when the same concentration of silk fibroin was applied for a coating. Therefore, SLA substrates were used for surface coating by an electrogel in this study.…”

“…The time for the completion of degradation mainly depends on the silk fibroin concentration and pore size inside the scaffolds. In Elia's study 37) , researchers explored drug release from an electrodeposited silk fibroin coating using FITC-dextrans. The drug release curve was in line with that observed in traditional systems.…”

Review of Electrochemically Triggered Macromolecular Film Buildup Processes and Their Biomedical Applications

“…185 Very recently, these gels were studied as potential coatings for bone implants. 186 To add an antibacterial activity, silk fibroins were chemically modified by tetracycline, a globally positively charged antibiotic. The obtained positively charged functionalized silk was deposited on a titanium cathode.…”

Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels

“…More recently electrodeposition has been extended to silk fibroin protein‐based gels (termed e‐gels) and this method provides a means to prepare silk‐based materials for emerging medical applications . These studies report a reversible electrogelation of silk films at an anode surface with the low localized pH adjacent to the anode being important for the deposition mechanism .…”