Hydroxyapatite Fibers: A Review of Synthesis Methods

Qi, Mei Li; He, Kun; Huang, Zhen; Shahbazian‐Yassar, Reza; Xiao, Gui Yong; Lu, Yu

doi:10.1007/s11837-017-2427-2

Cited by 25 publications

(17 citation statements)

References 84 publications

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“…Hydroxyapatite (HA), with the formula Ca 10 (PO 4 ) 6 (OH) 2 , is an important inorganic material that can potentially be employed for the preparation of magnetic composites, due to its good physicochemical stability, nontoxicity, and ease of surface modification. − Furthermore, HA has high ability to interact with proteins due to the positively charged calcium ions (Ca 2+ ) and charged oxygen ions associated with phosphate anions (PO 4 3– ) that interact electrostatically with side groups of proteins, as well as by the chelation of calcium ions of HA with electron donor amino acids of proteins . For these reasons, HA has been investigated as a support for protein adsorption in different areas, such as matrix of chromatographic columns to separate proteins, , in the medicine sector for bone regeneration, and in the pharmaceutical sector for drug delivery…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Coutinho

Malafatti

Paris

et al. 2020

ACS Appl. Nano Mater.

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Hydroxyapatite (HA) is an inorganic material with high ability to interact with proteins and has been recently explored as a support for enzyme immobilization. However, there are still some drawbacks concerning the recovery of these biocatalysts, which could be overcome using magnetic supports. Cobalt ferrite (CoFe 2 O 4 ) is a purely magnetic material, which offers excellent chemical stability, ease of synthesis, and mechanical hardness, being a promising candidate to form composites with HA and produce magnetic HA nanoparticles. Therefore, investigation of synthesis procedures and applications of HA/CoFe 2 O 4 composites to facilitate enzyme recovery by means of a magnetic field could find interest in a broad spectrum of biotechnological processes. Here, the co-precipitation method was used to synthesize HA/CoFe 2 O 4 composites with different HA/CoFe 2 O 4 mass ratios, for application as supports for enzyme immobilization. The enzymes β-glucosidase, phytase, and xylanase were selected for proof of concept due to their wide range of industrial applications. The composite with the highest cobalt ferrite content (2:1 mass ratio) was highly effective for immobilization of the three different enzymes, with immobilization yields (IYs) of 70−100% and recovered activities of 78−100%. The biocatalysts could be easily recovered from the reaction media by both centrifugation and application of an external magnetic field, demonstrating their potential for use in industrial processes. The materials exhibited good reusability, especially in the case of the βglucosidase biocatalyst, which could be reused 10 times, maintaining around 70% of its initial activity.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Coutinho

Malafatti

Paris

et al. 2020

ACS Appl. Nano Mater.

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“…When the sample is prepared by the classical hydrothermal treatment, two types of Ca 2+based complexes are formed. One is Ca-P 6 O 24 , which grows along the c-axis, and the other is OH-Ca 6 , which grows along the aand b-axes [13].…”

Section: -mentioning

confidence: 99%

Hydrothermal Synthesis of Hydroxyapatite Assisted by Gemini Cationic Surfactant

Zhang

Xiao

2020

Journal of Nanomaterials

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Hydroxyapatite (HAp) has been synthesized by a hydrothermal treatment in the presence of a Gemini cationic surfactant. This process is a new strategy of synthesis and mainly consists of two parts, i.e., an ordinary hydrothermal treatment and a liquid-solid-solution reaction (LSS strategy). Crystalline HAp nanorods or nanogranules with length of 50-180 nm and width of 30-40 nm were produced by ordinary hydrothermal treatment. By contrary, HAp spheres with a 3D architecture were fabricated with Gemini cationic surfactant by LSS strategy. For Gemini cationic surfactant concentration of 0.05%, spherical HAp particles with an average diameter of 1.7 μm were obtained.

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“…Recently, two review articles were published on HAP fibers and one-dimensional HAP materials including HAP nanowires. , However, the lengths of HAP nanowires reported in the literature are usually short (<10 μm). The synthesis of UHANWs (diameters <100 nm, lengths >100 μm) is a great challenge …”

Section: Synthesis Of Highly Flexible Uhanwsmentioning

confidence: 99%

“…In the crystal lattice, Ca 2+ ions occupy two sites: Ca(I) and Ca(II) . Ca 2+ ions may be substituted with Mg 2+ , Sr 2+ , Na + ions, etc., and PO 4 3– ions may be substituted with CO 3 2– , HPO 4 2– , SO 4 2– ions, etc., and OH – may be substituted with F – , Cl – ions, etc . In the carbonated apatite, either OH – ions or PO 4 3– ions are partially substituted with CO 3 2– ions to form A-type or B-type carbonated apatite …”

Section: Introductionmentioning

confidence: 99%

Deformable Biomaterials Based on Ultralong Hydroxyapatite Nanowires

Zhu

2019

ACS Biomater. Sci. Eng.

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Hydroxyapatite (HAP) biomaterials with high biocompatibility, bioactivity, and osteoconductivity/osteoinductivity have many applications in the biomedical fields. The traditional HAP materials usually feature high brittleness. Although hybridizing HAP with polymers can obtain deformable materials, their deformability is mainly contributed by polymers. Recently, research progress has been made in the deformable HAP biomaterials with high flexibility, softness, or elasticity based on ultralong HAP nanowires (UHANWs). This article provides a brief review on the recent progress on this research topic. Specifically, the strategy is proposed for solving the high brittleness of HAP biomaterials using UHANWs; the synthetic strategies for UHANWs are presented; and a variety of deformable biomaterials based on UHANWs are discussed. This review article provides a new concept of deformable biomaterials consisting of UHANWs and will stimulate new research works on deformable HAP biomaterials and further contribute to their development and applications in the biomedical fields such as bone regeneration, artificial periosteum, skin wound healing, biomedical paper, medical test paper, drug delivery, diagnosis, and therapy.

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Hydroxyapatite Fibers: A Review of Synthesis Methods

Cited by 25 publications

References 84 publications

Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Hydrothermal Synthesis of Hydroxyapatite Assisted by Gemini Cationic Surfactant

Deformable Biomaterials Based on Ultralong Hydroxyapatite Nanowires

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Hydroxyapatite Fibers: A Review of Synthesis Methods

Cited by 25 publications

References 84 publications

Hydroxyapatite-CoFe2O4 Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Hydroxyapatite-CoFe2O4 Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Hydrothermal Synthesis of Hydroxyapatite Assisted by Gemini Cationic Surfactant

Deformable Biomaterials Based on Ultralong Hydroxyapatite Nanowires

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Product

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Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery

Hydroxyapatite-CoFe₂O₄ Magnetic Nanoparticle Composites for Industrial Enzyme Immobilization, Use, and Recovery