Hydroxyapatite collagen scaffold with autologous bone marrow aspirate for mandibular condylar reconstruction

Howlader, Debraj; Vignesh, U; Bhutia, Dichen Palmo; Pandey, Rahul; Kumar, Sumit; Chandra, Tulika; Mehrotra, Divya

doi:10.1016/j.jcms.2017.06.022

Cited by 17 publications

(19 citation statements)

References 12 publications

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“…In comparison to synthetic materials, natural materials offer the distinct advantage of being naturally osteoinductive. Natural materials that have been explored for condylar bone replacement include coral [144] , chitosan [174] , and collagen [173] . Natural coral (porosity of 150-220 μm) was sculpted to resemble a condyle with a dental bur, and BMSCs were seeded at 20 million cells per construct.…”

Section: -4 Scaffoldsmentioning

confidence: 99%

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Tissue Engineering for the Temporomandibular Joint

Acri

Shin

Seol

et al. 2018

Adv Healthcare Materials

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Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.

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Section: -4 Scaffoldsmentioning

confidence: 99%

“…Clinical trial, 1 year Greatly increased mandible range of motion and patient quality of life [173] Chitosan PCL-HA-chitosan composite, Freeze dried…”

Section: Scaffold Materialsmentioning

confidence: 99%

Tissue Engineering for the Temporomandibular Joint

Acri

Shin

Seol

et al. 2018

Adv Healthcare Materials

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“…However, reconstruction of mandibular defects, postablative or posttemporomandibular joint ankylosis release, had been reported with unfractionated marrow/BMA with HA scaffolds. [1116]…”

Section: Discussionmentioning

confidence: 99%

Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies

et al. 2018

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Purpose:The aim of this study was to evaluate the bone regeneration potential of concentrated bone marrow aspirate (BMA)-coated hydroxyapatite (HA) for reconstruction of mandibular defects caused by the removal of benign pathologies.Patients and Methods:This prospective clinical study included ten patients with histopathologically proven benign pathologies of the mandible measuring <5 cm anteroposteriorly, who were treated with enucleation or marginal resection, followed by autologous concentrated BMA-coated synthetic biphasic HA (HA and beta-tricalcium phosphate) graft placement. Clinical and radiological evaluations of grafted sites of the mandible were done at 1 week, 1, 3, and 6 months postoperatively using Irwin's radiologic staging and grayscale histogram.Results:All patients (10/10, 100%) had proper incorporation of the graft with the normal adjacent bone. Grayscale histogram revealed the initial stages of graft resorption, followed by formation of new bone-grafted sites. No complications such as infection and total graft loss were encountered except for one patient who had partial wound dehiscence that responded well to local wound care and resuturing.Conclusion:Concentrated BMA-coated synthetic HA effectively promotes bone regeneration in small-to-moderate-sized defects of the mandible.

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“…It is mainly composed of three α -peptide chains or the peptide chains of α -chain. It is not easy to dissolve in alkali, weak acid and neutral salt, is not easy to be degraded by protease, and has the function of promoting coagulation and cell growth [28,29]. Compared with mammalian collagen, marine collagen is cheaper, easier to obtain, has lower melting point, and no risk of infectious diseases.…”

Section: Collagenmentioning

confidence: 99%

Prospective Applications of Marine Oriented Materials in the Repair of Peripheral Nerve Injury

Wang

et al. 2020

Adv. Mater. Lett.

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Hydroxyapatite collagen scaffold with autologous bone marrow aspirate for mandibular condylar reconstruction

Cited by 17 publications

References 12 publications

Tissue Engineering for the Temporomandibular Joint

Tissue Engineering for the Temporomandibular Joint

Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies

Prospective Applications of Marine Oriented Materials in the Repair of Peripheral Nerve Injury

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