Concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies

Abstract

Purpose:The aim of this study was to evaluate the bone regeneration potential of concentrated bone marrow aspirate (BMA)-coated hydroxyapatite (HA) for reconstruction of mandibular defects caused by the removal of benign pathologies.Patients and Methods:This prospective clinical study included ten patients with histopathologically proven benign pathologies of the mandible measuring <5 cm anteroposteriorly, who were treated with enucleation or marginal resection, followed by autologous concentrated BMA-coated synthetic biphasic HA (HA and beta-tricalcium phosphate) graft placement. Clinical and radiological evaluations of grafted sites of the mandible were done at 1 week, 1, 3, and 6 months postoperatively using Irwin's radiologic staging and grayscale histogram.Results:All patients (10/10, 100%) had proper incorporation of the graft with the normal adjacent bone. Grayscale histogram revealed the initial stages of graft resorption, followed by formation of new bone-grafted sites. No complications such as infection and total graft loss were encountered except for one patient who had partial wound dehiscence that responded well to local wound care and resuturing.Conclusion:Concentrated BMA-coated synthetic HA effectively promotes bone regeneration in small-to-moderate-sized defects of the mandible.

Reconstruction of craniofacial bone defects with autologous human bone marrow stem cells and autogenous bone grafts: A case report with review of literature

“…Gali et al [ 2 ] used concentrated bone marrow aspirate-coated hydroxyapatite for reconstruction of small-to-moderate-sized mandibular defects caused by the removal of benign pathologies. The aim was to evaluate the bone regeneration potential of the concentrate.…”

“…Although the use of VABGs in general has good outcome in terms of osteogenesis, osteoinduction, osteoconduction, and osseointegration at the recipient site, the drawbacks of this approach are donor site morbidity, increased operating time, increased recuperating time, failure of flap due to vascular compromise, and financial burden to the patient. [ 1 2 3 ] Other myriad of options for bony reconstruction include…”

Synthetic materials in craniofacial regenerative medicine: A comprehensive overview

“…The previous limitations and problems with the incorporation of cells, osteoconductivity, osteogenicity, and osteoinductivity in traditional grafts have triggered several pieces of multidisciplinary research on developing new tissue grafts and scaffolds over the last decade. Researchers from various specialties, such as clinicians, engineers, material scientists, chemists, and molecular biologists, have attempted to produce allogenic bone grafts using either mineralized or demineralized bone matrixed GFs, and SCs ( Figure 1 ) ( Gali et al, 2018 ). In addition, structural, mechanical, and spatial stimulation of the signal required for proper bone regeneration is exerted via developing natural-based nanocomposites ( Gali et al, 2018 ; Fragogeorgi et al, 2019 ).…”

“…Researchers from various specialties, such as clinicians, engineers, material scientists, chemists, and molecular biologists, have attempted to produce allogenic bone grafts using either mineralized or demineralized bone matrixed GFs, and SCs ( Figure 1 ) ( Gali et al, 2018 ). In addition, structural, mechanical, and spatial stimulation of the signal required for proper bone regeneration is exerted via developing natural-based nanocomposites ( Gali et al, 2018 ; Fragogeorgi et al, 2019 ). Despite the significant limitations of bone TE, such as lack of reproducibility, long-term viability, osseointegration, degree of internal revascularization, and anastomotic potential, ongoing research continues to construct an ideal engineered bone tissue ( Mercado-Pagán et al, 2015 ).…”