Hydroxyapatite/Collagen Composite Is a Reliable Material for Malar Augmentation

D’Agostino, Antonio; Trevisiol, Lorenzo; Favero, Vittorio; Gunson, Michael J.; Pedica, Federica; Nocini, Pier Francesco; Arnett, G. William

doi:10.1016/j.joms.2016.01.052

Cited by 27 publications

(37 citation statements)

References 39 publications

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“…The bone substitute Coll/Pro Osteon 200, compared with other biomaterials, gave remarkable aesthetic results, in terms of naturalness and symmetry. These data allowed us to give high VAS scores to patients . A 3‐year clinical study was performed to evaluate the long‐term results of new bone formation in patients (n = 50) who underwent malar augmentation during orthognathic surgical procedures.…”

Section: Resultsmentioning

confidence: 99%

“…Porous HA‐derived scaffold used herein is composed by Granular Pro Osteon200 (Interpore Cross Irvine, California) and Avitene Microfibrillar Collagen Hemostat (Bard Warwick, Rhode Island) (Coll) . This scaffold is named Coll/Pro Osteon 200.…”

Section: Methodsmentioning

confidence: 99%

“…Granular Pro Osteon 200 is a coralline HA, which is very similar in its make up to human bone mineral composition and form. The manufacturing scaffold using in vitro and in vivo evaluations was descried before in detail …”

Section: Methodsmentioning

confidence: 99%

“…The treatment plan, which aimed to achieve functional and esthetic improvement, was to enhance the malar area of patients with inadequate cheekbone projection or facial asymmetry. All orthognathic surgical procedures were carried out as previously described in the Arnett‐Gunson Center for Corrective Jaw Surgery (Santa Barbara, California) or at the Maxillofacial Surgery Unit of the University of Verona Medical Center (Verona, Italy) …”

Section: Methodsmentioning

confidence: 99%

“…Biopsy samples were obtained from implants in three patients who required plates removal at maxillae level 2 years after surgery. The material collected was treated as described . Morphologic and immunohistochemical analyses of bone samples were performed to evaluate remodeling and osteogenetic process.…”

Section: Methodsmentioning

confidence: 99%

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Hydroxylapatite-collagen hybrid scaffold induces human adipose-derived mesenchymal stem cells to osteogenic differentiation in vitro and bone regrowth in patients

Mazzoni

D’Agostino

Iaquinta

et al. 2019

Stem Cells Translational Medicine

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100

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Tissue engineering‐based bone graft is an emerging viable treatment modality to repair and regenerate tissues damaged as a result of diseases or injuries. The structure and composition of scaffolds should modulate the classical osteogenic pathways in human stem cells. The osteoinductivity properties of the hydroxylapatite‐collagen hybrid scaffold named Coll/Pro Osteon 200 were investigated in an in vitro model of human adipose mesenchymal stem cells (hASCs), whereas the clinical evaluation was carried out in maxillofacial patients. Differentially expressed genes (DEGs) induced by the scaffold were analyzed using the Osteogenesis RT2 PCR Array. The osteoinductivity potential of the scaffold was also investigated by studying the alkaline phosphatase (ALP) activity, matrix mineralization, osteocalcin (OCN), and CLEC3B expression protein. Fifty patients who underwent zygomatic augmentation and bimaxillary osteotomy were evaluated clinically, radiologically, and histologically during a 3‐year follow‐up. Among DEGs, osteogenesis‐related genes, including BMP1/2, ALP, BGLAP, SP7, RUNX2, SPP1, and EGFR, which play important roles in osteogenesis, were found to be upregulated. The genes to cartilage condensation SOX9, BMPR1B, and osteoclast cells TNFSF11 were detected upregulated at every time point of the investigation. This scaffold has a high osteoinductivity revealed by the matrix mineralization, ALP activity, OCN, and CLEC3B expression proteins. Clinical evaluation evidences that the biomaterial promotes bone regrowth. Histological results of biopsy specimens from patients showed prominent ossification. Experimental data using the Coll/Pro Osteon 200 indicate that clinical evaluation of bone regrowth in patients, after scaffold implantation, was supported by DEGs implicated in skeletal development as shown in “in vitro” experiments with hASCs.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Hydroxylapatite-collagen hybrid scaffold induces human adipose-derived mesenchymal stem cells to osteogenic differentiation in vitro and bone regrowth in patients

Mazzoni

D’Agostino

Iaquinta

et al. 2019

Stem Cells Translational Medicine

Self Cite

100

View full text Add to dashboard Cite

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An update on hydroxyapatite/collagen composites: What is there left to say about these bioinspired materials?

et al. 2021

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Hydroxyapatite (HAp)/collagen‐based composite materials have been a constant in the development of bioinspired materials for bone tissue engineering. The most fundamental research works focus on combining HAp, due to its chemical similarity with the mineral component of bones, and collagen, which is the most abundant protein in the body. Modern studies have explored different two‐dimensional (2D) and 3D structures, in order to obtain biomaterials with specific physicochemical, mechanical, and biological characteristics that can be applied in distinct biomedical applications. However, as there is already so much work developed with these materials, it is crucial to question: what can still be done? What is the importance of current know‐how for the future of bioinspired materials? In this paper we intend to review and update the available methodologies to synthesize HAp/collagen composites, along with their characteristics. In addition, the future of these materials in terms of applications and their potential as a cutting‐edge technology is discussed.

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Structure and stability analysis of biocompatible hydroxyapatite reinforced chitosan nanocomposite

Chakraborty¹,

Bhowmik

2018

Polymer Composites

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Nano‐hydroxyapatite has been used in multifunctional potential clinical applications where certain particle size distribution and morphology are required. The hydroxyapatite/chitosan composites were prepared using in situ co‐precipitation technique, influence of the reaction temperature on the crystallization and particle growth of the synthesized nano‐hydroxyapatite were examined. It was observed that the increase in synthesis temperature had a great influence on particle size and crystal structure of nano‐hydroxyapatite, whereas, the low temperature showed inhabitation of the hydroxyapatite growth in c‐direction and low crystallinity which was confirmed using XRD and electron diffraction pattern of TEM micrographs. The molar ratio of the bone‐like apatite layer for composite prepared at 70°C was higher was higher than the composites prepared at lower temperatures (40°C and −5°C). The AFM images of −5°C, 40°C, and 70°C n‐HAp/CTS composite display presence of CTS rich domains. These CTS rich and domains are made of smaller globular shaped particles in which, n‐HAp particles are embedded in the polymer matrix. The SBF degraded AFM surface topography of the composites shows the CTS is degraded fast rather the n‐HAp. The elastic modulus determined from nanoindentation of −5°C, 40°C, and 70°C n‐HAp/CTS composites are 17.91, 24.56, and 30.62 GPa respectively. Hardness values of the three composites in the same order were found to be 0.86, 1.35, and 1.74 GPa, respectively. Macro‐mechanical tests showed significant enhancement in elastic modulus, coefficient of friction and hardness of 70°C n‐HAp/CTS composites over −5°C and 40°C n‐HAp/CTS. However, the SBF degraded samples also performed moderate improvement in nanomechanical property. POLYM. COMPOS., 39:E573–E583, 2018. © 2018 Society of Plastics Engineers

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Hydroxyapatite/Collagen Composite Is a Reliable Material for Malar Augmentation

Cited by 27 publications

References 39 publications

Hydroxylapatite-collagen hybrid scaffold induces human adipose-derived mesenchymal stem cells to osteogenic differentiation in vitro and bone regrowth in patients

Hydroxylapatite-collagen hybrid scaffold induces human adipose-derived mesenchymal stem cells to osteogenic differentiation in vitro and bone regrowth in patients

An update on hydroxyapatite/collagen composites: What is there left to say about these bioinspired materials?

Structure and stability analysis of biocompatible hydroxyapatite reinforced chitosan nanocomposite

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