Hydroxyapatite–alendronate composite systems for biocompatible materials

Neamțu, Johny; Bubulica, Maria Viorica; Rotaru, Andrei; Ducu, Cătălin; Balosache, Oana Elena; Manda, Valentin Costel; Turcu-Știolică, Adina; Nicolicescu, Claudiu; Melinte, Razvan; Popescu, Mariana; Croitoru, Octavian

doi:10.1007/s10973-016-5905-9

Cited by 25 publications

(19 citation statements)

References 41 publications

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“…The structural characterization by X-ray diffraction (XRD) analysis conducted in a previous study confirmed that this method determined the synthesis of a hexagonal-crystallized single-phase hydroxyapatite [19].…”

Section: Synthesis and Characterization Of The Synthesized Hydroxyapasupporting

confidence: 63%

“…Moreover, the characteristic stretching vibration of the hydroxyl group of the hydroxyapatite molecule is observed at 3565 cm −1 in the HA-AL spectrum and at 3570 cm −1 , respectively. A more extensive spectrophotometric analysis of the composites was conducted in a previous study [19]. The MAPLE film spectrum is dominated by the absorption bands of HA, but some changes of the broad absorption band at 1500 are easily observed.…”

Section: Characterization Of the Synthesized Ha-al Compositementioning

confidence: 99%

“…Wet precipitation was the method chosen for hydroxyapatite synthesis. This method has several advantages such as a high degree of crystallinity depending on the synthesis conditions [19].…”

Section: Synthesis and Characterization Of The Synthesized Hydroxyapamentioning

confidence: 99%

“…Furthermore, a well-structured absorption band appears between 3000-3600 cm −1 for all composites, containing a medium intense band at 3565 cm −1 , characteristic for the hydroxyl group. Previous studies suggest that there are certain interactions between alendronate and hydroxyapatite that might involve the OH group [19,25].…”

Section: Synthesis and Characterization Of The Synthesized Hydroxyapamentioning

confidence: 99%

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Evaluation of Mesenchymal Stem Cells and Osteoblasts’ Adhesion and Proliferation in the Presence of HA-AL Biomaterials

et al. 2019

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There is an increased interest in developing biocomposite implants with high biocompatibility in order to be used as grafts or prostheses in orthopedic surgery. The purpose of the study was to determine the biocompatibility of titanium implants coated with synthesized hydroxyapatite-alendronate composites. The implants were obtained using Matrix Assisted Pulsed Laser Evaporation technique (MAPLE). The hydroxyapatite-alendronate composites were synthesized using the wet precipitation method. Immunofluorescence microscopy showed that composites support mesenchymal stem cells (MSCs) adhesion. Bone cells as well as human MSCs adhere to hydroxyapatite (HA)-based thin films obtained by matrix assisted laser deposition onto titanium. Alendronate doping into the films increased the number of cell-biomaterial focal points as compared to HA only. Thus, the synthesis of hydroxyapatite-alendronate composite (HA-AL) may be considered a viable solution for including the bisphosphonate on the surface of metallic prosthetic components used in orthopedics.

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Section: Synthesis and Characterization Of The Synthesized Hydroxyapasupporting

confidence: 63%

Section: Characterization Of the Synthesized Ha-al Compositementioning

confidence: 99%

“…Wet precipitation was the method chosen for hydroxyapatite synthesis. This method has several advantages such as a high degree of crystallinity depending on the synthesis conditions [19].…”

Section: Synthesis and Characterization Of The Synthesized Hydroxyapamentioning

confidence: 99%

Section: Synthesis and Characterization Of The Synthesized Hydroxyapamentioning

confidence: 99%

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Evaluation of Mesenchymal Stem Cells and Osteoblasts’ Adhesion and Proliferation in the Presence of HA-AL Biomaterials

et al. 2019

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“…The main thermal properties of the PCM/clay composite materials are phase change temperature, the heat of fusion and freezing, supercooling temperature, thermal reliability and stability, and thermal conductivity. These properties are mainly determined by the loaded PCM and can be measured with the complex of thermal analysis measurements, including differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and several thermal conductivity methods (e.g., the Transient Plane Source (TPS) method) [45][46][47][48][49]. An important property of PCM/clay composites is the loading efficiency of PCM that is derived as the mass fraction of the PCM in the composite container.…”

Section: Pcm/clay Composites For Thermal Energy Storagementioning

confidence: 99%

Clay Composites for Thermal Energy Storage: A Review

et al. 2020

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The development of novel materials and approaches for effective energy consumption and the employment of renewable energy sources is one of the current trends in modern material science. With this respect, the number of researches is focused on the effective harvesting and storage of solar energy for various applications. Phase change materials (PCMs) are known to be able to store thermal energy of the sunlight due to adsorption and release of latent heat through reversible phase transitions. Therefore, PCMs are promising as functional additives to construction materials and paints for advanced thermoregulation in building and industry. However, bare PCMs have limited practical applications. Organic PCMs like paraffins suffer from material leakage when undergoing in a liquid state while inorganic ones like salt hydrates lack long-term stability after multiple phase transitions. To avoid this, the loading of PCMs in porous matrices are intensively studied along with the thermal properties of the resulted composites. The loading of PCMs in microcontainers of natural porous or layered clay materials appears as a simple and cost-effective method of encapsulation significantly improving the shape and cyclic stability of PCMs. Additionally, the inclusion of functional clay containers into construction materials allows for improving their mechanical and flame-retardant properties. This article summarizes the recent progress in the preparation of composites based on PCM-loaded clay microcontainers along with their future perspectives as functional additives in thermo-regulating materials.

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Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

Poddar,

Singh,

Rao

et al. 2023

Macromolecular Bioscience

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Three‐dimensional scaffolds have huge limitations due to their low porosity, mechanical strength, and lack of direct cell‐bioactive drug contact. Whereas a drug like alendronate's ability to stimulate osteogenesis in osteoblasts and bone marrow mesenchymal stem cells has attracted its therapeutic use, it is hard to administer due to its low bioavailability, quick onset, and lack of site‐specificity. The proposed scaffold architecture allows cells to access the bioactive surface at their apex by interacting at the scaffold's interfacial layer. The interface has been coated with alendronate‐modified hydroxyapatite (MALD) enclosed in a chitosan matrix, the inner pore wall structure of 3D polycaprolactone (PCL) scaffolds to mimic the native environment and provide the direct interaction of cell to bioactive layer and mechanical strength will be provided by the skeleton of PCL. The MALD composite's HAP component will govern ALD's behavior, and local calcium ion concentration increases hMSC proliferation and differentiation. MALD showed total release of 86.28±0.22, and particle size of 273.7±108 nm. XPS and SEM investigation of the 3‐D PCL scaffold structure shows inspiring particle deposition with chitosan over the interface and reinforcing. All scaffolds enhanced cell adhesion, proliferation, and osteocyte differentiation for over a week without in vitro cell toxicity with 3.03±0.2 kPa mechanical strength.This article is protected by copyright. All rights reserved

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Hydroxyapatite–alendronate composite systems for biocompatible materials

Cited by 25 publications

References 41 publications

Evaluation of Mesenchymal Stem Cells and Osteoblasts’ Adhesion and Proliferation in the Presence of HA-AL Biomaterials

Evaluation of Mesenchymal Stem Cells and Osteoblasts’ Adhesion and Proliferation in the Presence of HA-AL Biomaterials

Clay Composites for Thermal Energy Storage: A Review

Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

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