Hydroxyacyl derivatives of forskolin—their positive inotropic activity

Direct Imine Acylation for Molecular Diversity in Heterocyclic Synthesis

“…The following substrates were commercially available and used as supplied: N -benzylidenemethylamine 1e , the amino acids 4a – d , the thioacids 6a – c , (3,4-dimethoxyphenyl)acetic acid 8c , 3-indoleacetic acid 8d , and 4,7-dimethoxy-1-naphthoic acid 8f . The following substrates were prepared according to literature procedures: imines 1a – d , Me-isoquinoline imine 1g , Ph-isoquinoline imine 1h , TBDMS-protected 3-hydroxypropanoic acid 2b , TBDMS-protected 4-hydroxybutanoic acid 2c , TBDMS-protected 3-hydroxybutanoic acid 2d , 2-(methoxycarbonyl)pentanedioic acid 1-methyl ester 8a , and 3-methyl-3-butenonic acid 8g …”

Diterpenoids (1998)

“…20 A number of water soluble and other derivatives of forskolin possessing useful inotropic activity, have been synthesized. 21,22 The unusual structure 16 of a diterpenoid obtained from the Japanese liverwort, Pallavicinia subciliata, may be derived 23 from a labdane by cleavage of the 7,8-bond as in 17.…”

Anti-HIV Diterpenes from Coleus forskohlii¶

“…Observation of anti HIV-activity of C. forskohlii extracts and of compounds isolated from them indicates the potential of forskolin (3) and related compounds for generating new lead molecules from new compounds synthesized earlier for SAR studies for various properties, such as adenyl cyclase activation, positive inotropic, anti glaucoma, anti inflammatory, bronchodialatory, and antihypertensive activities [11][12][13][14][15][16].…”