Hydrothermally deposited protective and bioactive coating for magnesium alloys for implant application

Asl, Sara Kaabi Falahieh; Németh, Sándor; Tan, Ming Jen

doi:10.1016/j.surfcoat.2014.07.055

Cited by 33 publications

(15 citation statements)

References 41 publications

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“…The hydrothermal Ca‐P deposition method was reported previously for inorganic Ca‐P coating . In this study, the phosphate and calcium ion precursors were also mixed with varying amounts of PAA or SCMC solution, and then the pH was adjusted to 3.8–4.0.…”

Section: Methodsmentioning

confidence: 99%

“…The hydrothermal Ca-P deposition method was reported previously for inorganic Ca-P coating. 35 In this study, the phosphate and calcium ion precursors were also mixed with varying amounts of PAA or SCMC solution, and then the pH was adjusted to 3.8-4.0. Next, AZ31 samples were immersed in the deposition solution, sealed in the autoclave, and heated in an electric oven at 1608C for 3 h. (Caution!…”

Section: Methodsmentioning

confidence: 99%

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Novel biodegradable calcium phosphate/polymer composite coating with adjustable mechanical properties formed by hydrothermal process for corrosion protection of magnesium substrate

2015

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Ceramic type coatings on metallic implants, such as calcium phosphate (Ca-P), are generally stiff and brittle, potentially leading to the early failure of the bone-implant interface. To reduce material brittleness, polyacrylic acid and carboxymethyl cellulose were used in this study to deposit two types of novel Ca-P/polymer composite coatings on AZ31 magnesium alloy using a one-step hydrothermal process. X-ray diffraction and scanning electron microscopy showed that the deposited Ca-P crystal phase and morphology could be controlled by the type and concentration of polymer used. Incorporation of polymer in the Ca-P coatings reduced the coating elastic modulus bringing it close to that of magnesium and that of human bone. Nanoindentation test results revealed significantly decreased cracking tendency with the incorporation of polymer in the Ca-P coating. Apart from mechanical improvements, the protective composite layers had also enhanced the corrosion resistance of the substrate by a factor of 1000 which is sufficient for implant application. Cell proliferation studies indicated that the composite coatings induced better cell attachment compared with the purely inorganic Ca-P coating, confirming that the obtained composite materials could be promising candidates for surface protection of magnesium for implant application with the multiple functions of corrosion protection, interfacial stress reduction, and cell attachment/cell growth promotion. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1643-1657, 2016.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Novel biodegradable calcium phosphate/polymer composite coating with adjustable mechanical properties formed by hydrothermal process for corrosion protection of magnesium substrate

2015

Self Cite

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“…Li et al coated the surface of pure magnesium with calcium phosphate by hydrothermal method [14]. Asl et al coated the surface of the AZ31 magnesium alloy with calcium phosphate by hydrothermal method at different temperatures [15]. Wang et al coated the ZK60 magnesium alloy with Sr doped hydroxyapatite at different doping ratios (3%, 5% and 10%) by hydrothermal method [16].…”

Section: Introductionmentioning

confidence: 99%

Production, Characterization and Surface Properties of Sr Doped Hydroxyapatite Coating on Magnesium Alloy by Hydrothermal Method

Gürgenç

2020

European Mechanical Science

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In this study, the surface of AZ91D magnesium alloy was coated with undoped and at different ratios strontium doped hydroxyapatite. Coatings were carried out at 180 °C in 3 hours. The surface roughness of the coated samples was determined and the microstructure of the phases forming on the coated surfaces were examined by scanning electron microscopy (SEM). The chemical composition of the phases formed on the coated surfaces was determined by energy dispersed X-ray spectroscopy (EDS). The phases formed on the surfaces were characterized by X-Ray diffraction (XRD) and Fourier transform infrared spectrometry (FT-IR). The AZ91D magnesium alloy was coated successfully with undoped and strontium doped hydroxyapatite by hydrothermal method. The highest surface roughness value was measured as R a = 8.255 µm in 15% strontium doped sample. It was determined that the (Ca + Sr) / P ratios of the coatings were higher than the stoichiometric ratio of hydroxyapatite, 1.67. It was determined that the closest coating to the stoichiometric ratio was 10% Sr doped coating.

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“…The hydrothermal process is a useful method for the deposition of the Ca-P and Ca-P /Polymer composite coatings on AZ31 substrate [174] as explained in Chapter 4, and other metallic substrates [139] which resulted from the solutions' supersaturation.…”

Section: Structure and Chemical Composition Of Coatingsmentioning

confidence: 99%

“…Until now, Ca-P inorganic and Ca-P/Polymer composite coatings were successfully deposited on the AZ31 substrate by means of hydrothermal method, which offered good corrosion performance, mechanical properties, degradation behavior as well as cell attachments [174,190,216,217]. Apart from that, inhibiting bacterial adhesion is essential to prevent implant-associated infection, because biofilms are extremely resistant to both the immune system and antibiotics.…”

Section: Anti-infective Coatings With Local Drug Delivery Abilitymentioning

confidence: 99%

Surface modification and corrosion properties of Mg based alloys for bio-implant application

Asl¹

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The use of implants for bone repair has a considerable and successful history. Traditionally, metallic implants have been used in such a way that the implant would be surgically removed after sufficient bone healing has been achieved. During the last decade, interest in biodegradable magnesium (Mg) implants has increased dramatically. The use of Mg is based on the fact that Mg is one of the essential elements for human metabolism, and the density and elastic modulus of Mg are close to the human bone, thus, avoiding stress shielding effect. However, Mg alloys corrodes too rapidly, resulting in hydrogen evolution and consequently, local alkalization close to the surgery region as well as premature degradation in the implant's mechanical integrity before bone healing occurred. All these factors impede the practical applications of Mg implants. In this study, a hydrothermal coating process was used to provide, uniform and biodegradable inorganic calcium-phosphate (Ca-P) and calcium-phosphate/polymer (Ca-P/Polymer) composite coatings on AZ31 magnesium substrate that slow the corrosion of Mg and to meet different requirements for implant application. In the current study two different types of novel Ca-P/Polymer composites coatings were successfully deposited for the first time on AZ31 magnesium alloy to reduce CaP material brittleness by using polyacrylic acid and carboxymethyl cellulose polymers. The results showed, crystal phase and coating's morphology could be successfully controlled by the type and concentration of polymer used which could affect the coating's degradation rate as well. Incorporation of polymer in the CaP coatings reduced the coating elastic modulus bringing it close to that of Mg and that of human bone. Apart from mechanical properties, cell proliferation studies indicated that composite coatings induced better cell attachment compared to the purely inorganic CaP coating.

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Hydrothermally deposited protective and bioactive coating for magnesium alloys for implant application

Cited by 33 publications

References 41 publications

Novel biodegradable calcium phosphate/polymer composite coating with adjustable mechanical properties formed by hydrothermal process for corrosion protection of magnesium substrate

Novel biodegradable calcium phosphate/polymer composite coating with adjustable mechanical properties formed by hydrothermal process for corrosion protection of magnesium substrate

Production, Characterization and Surface Properties of Sr Doped Hydroxyapatite Coating on Magnesium Alloy by Hydrothermal Method

Surface modification and corrosion properties of Mg based alloys for bio-implant application

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