Hydrothermal synthesis of porous triphasic hydroxyapatite/(α and β) tricalcium phosphate

Vani, R. M.; Girija, E. K.; Kolanthai, Elayaraja; Parthiban, S.; Kesavamoorthy, R.; Kalkura, S. Narayana

doi:10.1007/s10856-008-3480-8

Cited by 63 publications

(42 citation statements)

References 28 publications

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“…It is usually prepared by heating ACP precursors (Wang et al 2006a;Li et al , 2008a, in which the a-TCP/b-TCP ratio can be controlled by aging time and pH value during synthesis of the amorphous precursor ). Furthermore, triphasic formulations, consisting of HA, a-TCP and b-TCP (Vani et al 2009) or HA, a-TCP and TTCP (Nakano et al 2002b) have been prepared (Dorozhkin 2012d).…”

Section: Biphasic Triphasic and Multiphasic Capo 4 Formulationsmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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Section: Biphasic Triphasic and Multiphasic Capo 4 Formulationsmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…The biphasic TCP is usually prepared by heating ACP precursors [139][140][141], in which the α-TCP/β-TCP ratio can be controlled by aging time and pH value during synthesis of the amorphous precursor [140]. Furthermore, a triphasic formulation, consisting of HA, α-TCP and β-TCP has been prepared [142].…”

Section: Chemical Composition and Preparationmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…[10][11][12][13][14][15][16][17] Because HA is a primary mineral component of natural bone and possesses outstanding bioactivity, osteoconductivity, biocompatibility with bone cells, good mechanical properties, and a slow degradation rate in vivo, it has often been the first choice for modifying collagen scaffolds. 10,[18][19][20] Although directly mixing collagen with HA powders in certain proportions can result in collagen scaffolds with compositions similar to those of natural bone tissues, it is difficult to simulate their microstructure and microenvironment via this process. Therefore, to solve the aforementioned problems, researchers are devoting more attention to the biomimetic mineralization of collagen scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects

Wang¹,

Manh²,

Wang³

et al. 2016

IJN

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The mineralization of collagen scaffolds can improve their mechanical properties and biocompatibility, thereby providing an appropriate microenvironment for bone regeneration. The primary purpose of the present study is to fabricate a synergistically intra- and extrafibrillar mineralized collagen scaffold, which has many advantages in terms of biocompatibility, biomechanical properties, and further osteogenic potential. In this study, mineralized collagen scaffolds were fabricated using a traditional mineralization method (ie, immersed in simulated body fluid) as a control group and using a biomimetic method based on the polymer-induced liquid precursor process as an experimental group. In the polymer-induced liquid precursor process, a negatively charged polymer, carboxymethyl chitosan (CMC), was used to stabilize amorphous calcium phosphate (ACP) to form nanocomplexes of CMC/ACP. Collagen scaffolds mineralized based on the polymer-induced liquid precursor process were in gel form such that nanocomplexes of CMC/ACP can easily be drawn into the interstices of the collagen fibrils. Scanning electron microscopy and transmission electron microscopy were used to examine the porous micromorphology and synergistic mineralization pattern of the collagen scaffolds. Compared with simulated body fluid, nanocomplexes of CMC/ACP significantly increased the modulus of the collagen scaffolds. The results of in vitro experiments showed that the cell count and differentiated degrees in the experimental group were higher than those in the control group. Histological staining and micro-computed tomography showed that the amount of new bone regenerated in the experimental group was larger than that in the control group. The biomimetic mineralization will assist us in fabricating a novel collagen scaffold for clinical applications.

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Hydrothermal synthesis of porous triphasic hydroxyapatite/(α and β) tricalcium phosphate

Cited by 63 publications

References 28 publications

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Medical Application of Calcium Orthophosphate Bioceramics

Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects

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