Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging

Yang, Yang; Sun, Yun; Cao, Tianye; Peng, Juanjuan; Liu, Ying; Wu, Yongquan; Feng, Wei; Zhang, Yingjian; Li, Fuyou

doi:10.1016/j.biomaterials.2012.10.022

Cited by 162 publications

(98 citation statements)

References 42 publications

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“…All of these analyses can be conveniently conducted on standard instruments. Hematological and blood biochemical analyses of murine blood injected w i t h v a r i o u s l a n t h a n i d e o x i d e 7 0 0 , 7 0 5 a n d fl uoride 425,487,576,583,584,699 nanoparticles reveal no significant hematological irregularities or impairment of organ functions.…”

Section: Chemical Reviewsmentioning

confidence: 96%

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Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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Section: Chemical Reviewsmentioning

confidence: 96%

“…The effect on physical and behavioral signs caused by the introduction of a wide variety of nanoparticles is investigated, 425,487,576,583,584,697,699,700 and the results generally indicate no significant changes as compared to control groups (Figure 72a).…”

Section: Chemical Reviewsmentioning

confidence: 97%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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“…Lu 3+ , Yb 3+ and Gd 3+ ions doped NPs have been applied as effective CT contrast agents [109][110][111]. The radionuclides, 18 F -and 153 Sm 3+ ions were widely introduced into the lattice of UCNPs to endow them PET and SPECT imaging capabilities [112,113]. Moreover, this doping approach is of benefit to control over the fabrication of smaller NPs, as well as to avoid complicated synthesis procedures.…”

Section: Ln-based Ucnps For Multimodal Cancer Imagingmentioning

confidence: 98%

Multimodal Cancer Imaging Using Lanthanide-Based Upconversion Nanoparticles

Yang

Lin

2015

Nanomedicine (Lond.)

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Multimodal nanoprobes that integrate different imaging modalities in one nano-system could offer synergistic effect over any modality alone to satisfy the higher requirements on the efficiency and accuracy for clinical diagnosis and medical research. Upconversion nanoparticles (UCNPs), particularly lanthanide (Ln)-based NPs have been regarded as an ideal building block for constructing multimodal bioprobes due to their fascinating properties. In this review, we first summarize recent advances in the optimizations of existing UCNPs. In particular, we highlight the applications of Ln-based UCNPs for multimodal cancer imaging in vitro and in vivo. The explorations of UCNPs-based multimodal nanoprobes for targeting diagnosis and imaging-guided therapeutics are also presented. Finally, the challenges and perspectives of Ln-based UCNPs in this rapid growing field are discussed.

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“…This information about distribution/excretion of UCNPs in vivo can be extremely helpful before they can be used as a contrast agent for detection of a specific disease. Similar technique was used by the same group to monitor in vivo behavior of UCNPs with different chemical compositions and different synthesis method (20). In another study, 99m Tc-labeled mannosylated Gantrez nanoparticles were studied in mice for their organ distribution (post-loading with the Brucella ovis antigen) after ocular administration (21).…”

Section: In Vivo Kinetics Of Radio-nanomaterialsmentioning

confidence: 99%

Radio-nanomaterials for biomedical applications: state of the art

Hong

Cai

2016

European Journal of Nanomedicine

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The incorporation of radioactive isotope(s) into conventional nanomaterials can bring extra properties which are not possessed by original materials. The resulting radioactive nanomaterials (radio-nanomaterials), with added physical/chemical properties, can be used as important tools for different biomedical applications. In this review, our goal is to provide an up-to-date overview on these applications using radio-nanomaterials. The first section illustrates the utilization of radionanomaterials for understanding of in vivo kinetics of their parent nano-materials. In the second section, we focus on two primary applications of radio-nanomaterials: imaging and therapeutic delivery. With various methods being used to form radio-nanomaterials, they can be used for positron emission tomography (PET), single-photon emission computed tomography (SPECT), and multimodal imaging. Therapeutic isotopes-loading radio-nanomaterials can possess selective killing efficacy of diseased cells (e.g. tumor cells) and can provide promises for certain isotopes which are not able to be used in a conventional manner. The successful and versatile biomedical applications of radio-nanomaterials warrants further investigations of those materials and their optimizations can pave the way to future imaging guidable, personalized treatments in patients.

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Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging

Cited by 162 publications

References 42 publications

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Multimodal Cancer Imaging Using Lanthanide-Based Upconversion Nanoparticles

Radio-nanomaterials for biomedical applications: state of the art

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