Hydrotalcites with heterogeneous anion distributions: a first approach to producing new materials to be used as vehicles for the successive delivery of compounds
Abstract:Hydrotalcites with heterogeneous distributions of anions between their layers were synthesized. Some synthesis parameters were studied to verify their influence on the anionic segregation properties of the hydrotalcites. The nature of the divalent cation and the crystallization method were most relevant. Zinc, in contrast to magnesium, assisted in discriminating carbonates and attracting nitrates to form hydrotalcites with heterogeneous distributions using microwave irradiation. Furthermore, the identification… Show more
“…This difference may be attributed to the presence of mostly interlayered nitrates rather than carbonates in the sample containing zinc, while the sample containing magnesium is richer in carbonates. [14] The peaks appearing at 61-63° (2θ), corresponding to the 110 and 113 reflections, are not well resolved. This could be due by the presence of copper, which introduces serious deformations in the octahedron coordination structure leading to a reduction of crystallinity [15] mostly in presence of magnesium.…”
Pathogenic bacteria contamination can cause a serious hazard to human health. The use of bactericidal materials, such as layered double hydroxides (LDH), might constitute a way of reducing the risk of diseases. In this work, novel hybrid-LDH compounds were synthesized by integrating eucalyptol and copper in ZnAl-and MgAl-LDH materials to promote the biocidal activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The addition of copper to LDH clays significantly enhance the bactericidal activity, with MIC values as low as 0.5 mg/mL for S. aureus and 8.0 mg/mL for P. aeruginosa, while eucalyptol scarcely contributed to the biocidal efficiency.
“…This difference may be attributed to the presence of mostly interlayered nitrates rather than carbonates in the sample containing zinc, while the sample containing magnesium is richer in carbonates. [14] The peaks appearing at 61-63° (2θ), corresponding to the 110 and 113 reflections, are not well resolved. This could be due by the presence of copper, which introduces serious deformations in the octahedron coordination structure leading to a reduction of crystallinity [15] mostly in presence of magnesium.…”
Pathogenic bacteria contamination can cause a serious hazard to human health. The use of bactericidal materials, such as layered double hydroxides (LDH), might constitute a way of reducing the risk of diseases. In this work, novel hybrid-LDH compounds were synthesized by integrating eucalyptol and copper in ZnAl-and MgAl-LDH materials to promote the biocidal activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The addition of copper to LDH clays significantly enhance the bactericidal activity, with MIC values as low as 0.5 mg/mL for S. aureus and 8.0 mg/mL for P. aeruginosa, while eucalyptol scarcely contributed to the biocidal efficiency.
“…37 In order to further prove the presence of anion species in the intercalation of hydrotalcite materials and the structural when Na 2 CO 3 was used as the precipitant during the coprecipitation process, but no NO 3 À decomposition was observed in the calcination process, which showed that CO 3 2À anions were easier to enter the interlayer of hydrotalcite than NO 3 À ions. 35,40 On the other hand, in the samples prepared with mixed alkali as the precipitant, only a small amount of NO 2 was released at near 330 C, indicated that only a trace amount of NO 3 À ions existed in the CuMgAl-Mix and the NO 3 À can be completely decomposed below 330 C. From the mass spectrum signal of CO 2 in Fig. 4C, it can be seen that CO 2 was released in all samples during high-temperature decomposition.…”
Highly efficient synthesis of 1,4-pentanediol (1,4-PDO) from industrialized biomass-based products is still a challenge due to the inherent chemical stability of intermediate product γ-valerolactone. The aim of the present research...
“…The Coprecipitation technique is the most common method to prepare iron oxide nanoparticles. Both sodium hydroxide (NaOH) and ammonium hydroxide (NH 4 OH) have been used to detect whether the basicity manipulates the crystallization process during particle formation 8,32 . Various surface modification techniques have been used to enhance nanoparticles' diagnosis and therapeutics potential in biomedicine applications 6 .…”
Vaccination has been used effectively to protect from infectious diseases and non-infectious diseases such as cancer and allergies. Different forms of particulate arrangements, including nanoparticles, virus-like particles (VLPs), and virosomes, have been built recently depending on the type of pathogen to be targeted. The ability to conjugate the recombinant Plasmodium yoelii, 19-kDa C-terminal fragment of merozoite surface protein 1 (PyMSP119) on the surface of superparamagnetic magnetite nanoparticles (SPIONs) was explored as a new technique of enhancing vaccination against malaria. Different conjugation strategies were performed to correlate the effects of nanoparticle chemistry surfaces to bind later with the malaria protein. (SPIONs) were prepared by chemical coprecipitation method and coated with 3-aminopropyltriethoxysilane (APTS) alone (as a surface coater), or with both APTS and polyethylene glycol (PEG) (as a shield to protect the malaria protein from proteolytic enzymes) by using a modified silanisation method.
X-ray powder diffraction (XRD, Philips Model) patterns indicated that the SPIONs were of high purity with an inverse spinal structure. Fourier Transform Infrared Spectroscopy (FTIR) was collected using PerkinElmer Spectrum 100 Series; spectra of uncoated and coated magnetite nanoparticles confirmed that the silane layer had been coated on the surface Fe3O4. The SPIONs were superparamagnetic as investigated by Vibrating Sample Magnetometry (VSM, Princeton Applied Research, model ISS) and relatively stable in aqueous phase at room temperature and could also be quickly recovered from suspension using an external magnet. Introduce the carboxyl groups onto the SPIONs surfaces, resulting in a relatively high protein binding capacity onto the nanoparticle surfaces.
The bare particles had a mean size of around 20 nm with a relatively narrow size distribution. 82% of African Green Monkey fibroblast (COS-7) were alive in nanoparticle suspension using the MTT assay method. The quantity of protein explicitly bound to particles was determined using Sodium Dodecyl Sulfate (SDS) - Polyacrylamide Gel Electrophoresis (PAGE). SDS–PAGE. When the conjugation blend was prepared in EDC, there was approximately 100% binding between PyMSP119 and the Fe3O4-COOH particles because no protein band was apparent at the expected molecular weight for PyMSP119 (45 kDa).
The current study investigates the theory that the gradual, persistent release of the malaria antigen may stimulate and maintain an elevated level of immune response for an extended period in vivo, which will be the scope of future work.
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