Hydrophobicity as a Key Physicochemical Parameter of Environmental Toxicology of Pesticides

Fujita, Toshio; Nishimura, Keiichiro; Takayama, Chiyozo; Yoshida, Masanori; Uchida, Matazaemon

doi:10.1016/b978-0-12-374367-1.00058-6

Cited by 3 publications

(1 citation statement)

References 136 publications

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“…Lipophilic insecticides could bioaccumulate and reach toxic local concentrations. This should be evaluated to consider their exposure estimation to humans in the environment. − Their binding ability is determined primarily by their lipophilicity, which provides the basis for estimating their bioaccumulation and adsorption. In living organisms, pesticides are mainly distributed by binding to plasma proteins, blood cells, and lipids in diverse organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes

Gastaldi

Felsztyna

Miguel

et al. 2023

J. Agric. Food Chem.

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Fluralaner is a relatively new insecticide belonging to the isoxazoline group, whose action mechanism involves the blocking of GABA A -receptors in the insect nervous system. Because of its high hydrophobicity, fluralaner could bioaccumulate and reach toxic local concentrations. Since there are no data available about the penetration and persistence of isoxazolines in biological membranes, we intend to evaluate fluralaner permanence as a pollutant by using model membranes. We used experimental and in silico models to characterize the incorporation of fluralaner into the lipid phase at different packing states. We determined its impact in the membrane structure and organization. Our results confirm that fluralaner is capable of penetrating, holding, and accumulating in the lipid membrane and provide details on its precise location and orientation. These properties would allow fluralaner to reach high local concentrations in different membranes and organs, which could be dangerous for vertebrate organisms if its handling is not properly controlled.

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Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes

Gastaldi

Felsztyna

Miguel

et al. 2023

J. Agric. Food Chem.

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Reducing Ecotoxicity

Solomon

Hanson

2012

Handbook of Green Chemistry

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The sections in this article are Introduction to Key Aspects of Ecotoxicology Protection Goals and Assessment Endpoints Structure and Function in Ecosystems Diversity of Sensitivity in Ecosystems Hazard Assessment and Uncertainty Environmental Fate and Pathways of Exposure to Chemicals in the Environment Properties Affecting Bioavailability Properties Affecting Bioconcentration and Biomagnification Absorption, Distribution, Metabolism, and Excretion of Chemicals Modeling Exposure Mechanisms of Toxic Action Properties Affecting Toxicity Modeling Toxicity Examples of Methods That Can Be Used in Designing Chemicals with Reduced Ecological Risks Fluorinated Surfactants Pesticides Designing Pesticides for Lack of Persistence Designing Specific Isomers to Reduce Risk in the Environment Developing Pesticides That Are More Specific to the Target Organism Ranking and Prioritizing Pesticides in Terms of Risk to the Environment Pharmaceuticals Macro‐ and Micro‐Contaminants Produced During Manufacture Overview, Conclusions, and the Path Forward

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Toxicity of representative organophosphate, organochlorine, phenylurea, dinitroaniline, carbamate, and viologen pesticides to the growth and survival of H. vulgaris, L. minor, and C. elegans

Rivenbark,

Nikkhah,

Wang

et al. 2024

Environ Sci Pollut Res

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Hydrophobicity as a Key Physicochemical Parameter of Environmental Toxicology of Pesticides

Cited by 3 publications

References 136 publications

Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes

Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes

Reducing Ecotoxicity

Toxicity of representative organophosphate, organochlorine, phenylurea, dinitroaniline, carbamate, and viologen pesticides to the growth and survival of H. vulgaris, L. minor, and C. elegans

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