Hydrophobic resin treatment of hydrothermal autohydrolysate for prebiotic applications

Corbett, Derek B.; Hong, Chang-Young; Venditti, Richard A.; Jameel, Hasan; Park, Sunkyu

doi:10.1039/c9ra06018a

Cited by 8 publications

(4 citation statements)

References 27 publications

(46 reference statements)

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“…Although the resin was able to recover 98 % of lignin in the hydrolysate, XADL contained a very high amount of carbohydrates (Table ). While the inclusion of some oligomeric xylan in XADL cannot be ruled out, these results indicate the possibility of the involvement of LCC in the resolution of lignin during hydrothermal pretreatment.…”

Section: Resultsmentioning

confidence: 99%

Tracing Sweetgum Lignin's Molecular Properties through Biorefinery Processing

et al. 2020

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Changes to the molecular properties of lignin over the course of biorefinery processing were investigated by using sweetgum as a feedstock. Hydrothermal pretreatment has been used because it is an economically attractive, green process. Three representative biorefinery lignin preparations were obtained, with about 70 % yield based on raw lignin. The three fractions included soluble lignin adsorbed on resin (XADL), solvent‐extracted lignin (HTCELp), and an additional ball‐milled residual lignin (HTRELp). By comparing the raw and biorefinery lignin preparations, it can be concluded that lignin undergoes both degradation and condensation throughout the various stages of the hydrothermal‐based biorefinery process. The two fractions made soluble by biorefinery processing, XADL and HTCELp, were found to be low‐molecular‐weight degradation products enriched with free phenolic hydroxyl groups. In addition, about 15 % of noncondensed phenolic units were involved in condensation reactions. Quantitative NMR spectroscopy analysis revealed that at least about 28 % of β‐O‐4′ substructures were cleaved. Hibbert's ketones were identified in XADL and HTRELp, which provided evidence of lignin undergoing acidolysis. The contents of β‐5′ and β‐β′ did not change significantly upon biorefinery processing. Finally, episyringaresinol was detected in XADL and HTCELp. It is hoped that these findings will help to further demonstrate the specific effects of biorefinery processing on lignin in hardwood and facilitate its utilization to improve biorefinery economics.

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Section: Resultsmentioning

confidence: 99%

Tracing Sweetgum Lignin's Molecular Properties through Biorefinery Processing

et al. 2020

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Section: Methodsmentioning

confidence: 99%

“…The adsorbent resins were pretreated before use to remove preservative salts and impurities if any. Resin was washed thoroughly with methanol at 30 min intervals between subsequent cycles, followed by distilled water wash. 43 The resin was then dried for 24 h at 50 °C. Hydration of the resins was carried out with absolute ethanol owing to their hydrophobic character making permeation easier.…”

Section: Methodsmentioning

confidence: 99%

An Adsorption Based Downstream Processing Approach for Penicillin V from a Penicillium chrysogenum BIONCL I22 Culture Filtrate

Mishal,

Das,

Mahajan

et al. 2024

ACS Omega

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Penicillin V (phenoxy methyl penicillin) is highly sought after among natural penicillins because of its exceptional acid stability and effectiveness against common skin and respiratory infections. Given its wide-ranging therapeutic uses, there is a need to establish a greener method for its maximum recovery to reduce the carbon footprint. Here, we have identified and validated optimized operational conditions for resin-based penicillin V recovery. It was observed that Amberlite XAD4 had the highest penicillin V hydrophobic adsorption capacity among the other screened resins. Kinetic and isothermal studies using linear and nonlinear regression analysis showed that the adsorption process well fitted with pseudo-second-order kinetics (R 2 = 0.9816) and the Freundlich adsorption isotherm model (R 2 = 0.9871). Adsorption equilibrium was attained within 4 h, while maximum adsorption was observed at 3 mg/mL penicillin V concentration. Furthermore, the optimized extraction protocol was compared with the conventional butyl acetate-based downstream processing. Under optimum conditions resin-based penicillin V recovery was 2-fold higher as compared to the solvent extraction method and the resin could be reused for over six cycles without compromising the yield. These findings signify substantial progress toward the development of an environmentally sustainable approach for penicillin V recovery and a potentially viable method for extractive fermentation.

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“…XOS prebiotics are a value-added product from lignocellulosic bioreneries based on autohydrolysis or related pretreatment technologies. 117 When using XOS as a food additive, the residual lignin in the XOS can also alter the human intestinal tract and play an anti-tumor role.…”

Section: Anti-tumor Activity Of Gut Microbiotamentioning

confidence: 99%

Structural features, interaction with the gut microbiota and anti-tumor activity of oligosaccharides

Chen

et al. 2020

RSC Adv.

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Hydrophobic resin treatment of hydrothermal autohydrolysate for prebiotic applications

Abstract: ∼30% of xylooligosaccharides (XOS) in autohydrolysate are likely bonded to lignin “tied,” contributing to loss during resin purification. Loss of “free” XOS depends on DP.

Cited by 8 publications

References 27 publications

Tracing Sweetgum Lignin's Molecular Properties through Biorefinery Processing

Tracing Sweetgum Lignin's Molecular Properties through Biorefinery Processing

An Adsorption Based Downstream Processing Approach for Penicillin V from a Penicillium chrysogenum BIONCL I22 Culture Filtrate

Structural features, interaction with the gut microbiota and anti-tumor activity of oligosaccharides

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