Hydrophobic Polymers of Pharmaceutical Significance

Abu-Diak, Osama A.; Andrews, Gavin; Jones, David S.

doi:10.1007/978-1-4614-0881-9_3

Cited by 8 publications

(5 citation statements)

References 93 publications

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“…In contrast to physical foaming of TPUs via CO 2 , in which the content of hard segments [ 82 ] and the soft segment chain length [ 90 ] are the main influencing factors in terms of the expansion ratio, the present findings show that the similarity of the gases produced (in the present case H 2 O and CO 2 ) together with the TPU type (hydrophobic or hydrophilic) can play a major role in determining the nucleation rate of the pores. This finding is of paramount importance for pharmaceutical applications since both porosity and hydrophobicity have a significant influence on liquid absorption (see Section 3.6 ) and thus on the drug release [ 91 , 92 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

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Section: Resultsmentioning

confidence: 99%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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“…Organic nanocarriers are generally characterized by their tunable morphology, colloidal stability, relatively large size, high biocompatibility and improved drug loading capacity, which make them suitable for transporting a wide variety of drugs [ 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. However, it is very important to make sure that the polymeric drug nanocarriers are safe and do not trigger cytotoxicity at the tissue level.…”

Section: Polymer-based Smart Nanocarriersmentioning

confidence: 99%

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Nikkhah

Thompson

2021

Pharmaceutics

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Nanomedicine employs molecular materials for prevention and treatment of disease. Recently, smart nanoparticle (NP)-based drug delivery systems were developed for the advanced transport of drug molecules. Rationally engineered organic and inorganic NP platforms hold the promise of improving drug targeting, solubility, prolonged circulation, and tissue penetration. However, despite great progress in the synthesis of NP building blocks, more interdisciplinary research is needed to understand their self-assembly and optimize their performance as smart nanocarriers. Multi-scale modeling and simulations provide a valuable ally to experiment by mapping the potential energy landscape of self-assembly, translocation, and delivery of smart drug-loaded NPs. Here, we highlight key recent advances to illustrate the concepts, methods, and applications of smart polymer-based NP drug delivery. We summarize the key design principles emerging for advanced multifunctional polymer topologies, illustrating how the unusual architecture and chemistry of dendritic polymers, self-assembling polyelectrolytes and cyclic polymers can provide exceptional drug delivery platforms. We provide a roadmap outlining the opportunities and challenges for the effective use of predictive multiscale molecular modeling techniques to accelerate the development of smart polymer-based drug delivery systems.

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“…On the other hand, Eudragit RS is a hydrophobic matrix former insoluble in aqueous media. It delays the penetration of release medium into the matrix and sustains the drug release (Abu-Diak et al, 2012).…”

Section: Samplingmentioning

confidence: 99%