Hydrophobic modification of high molar mass polyglycidol to thermosensitive polymers

Jamróz-Piegza, Maria; Utrata-Wesołek, Alicja; Trzebicka, Barbara; Dworak, Andrzej

doi:10.1016/j.eurpolymj.2006.04.017

Cited by 47 publications

(41 citation statements)

References 32 publications

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“…The thermoresponsive behavior can be attributed to the combination of the hydrophilic segments (such as ÀOH, ÀCH 2 ÀOÀ, and >CHÀOÀ) and hydrophobic segments (such as ÀCH 3 and >C<) in the polymer backbone. [8,11] When the temperature is above the LCST, the interaction of the hydrophobic segments drives the molecular chains to aggregate and then separate from water. Their LCST transitions as well as the corresponding molecular mechanism were studied by variable temperature UV-Vis spectrometry and 1 H NMR, respectively.…”

Section: Thermoresponsive Behaviors Of Hp(g-co-m)smentioning

confidence: 99%

Backbone‐Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3‐Methyl‐3‐(hydroxymethyl)oxetane

Xia¹,

Wang²,

Wang³

et al. 2011

Macro Chemistry & Physics

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The hyperbranched polyglycerol analog, hyperbranched poly[glycerol‐co‐3‐methyl‐3‐(hydroxymethyl)oxetane] [HP(G‐co‐M)], was synthesized in one‐step by random copolymerization of glycidol and 3‐methyl‐3‐(hydroxymethyl)oxetane (MHO). The obtained polymer exhibited a thermoresponsive behavior in an aqueous solution, and the corresponding lower critical solution temperature (LCST) could be readily adjusted by changing the feed ratio of glycidol to MHO. The MTT assay against COS‐7 cells demonstrated that HP(G‐co‐M) had low cytotoxicity. Moreover, the existence of numerous hydroxyl terminals of HP(G‐co‐M) facilitated their further modification and functionalization. All of these characteristics suggest that this novel backbone‐thermoresponsive hyperbranched polyglycerol is a promising functional material for biomedical applications. magnified image

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Section: Thermoresponsive Behaviors Of Hp(g-co-m)smentioning

confidence: 99%

Backbone‐Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3‐Methyl‐3‐(hydroxymethyl)oxetane

Xia¹,

Wang²,

Wang³

et al. 2011

Macro Chemistry & Physics

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“…Polyglycidol is a water soluble and highly hydrophilic polymer. To induce its thermoresponsive behavior, the hydroxy groups have been modified with acetate or ethyl carbamate groups . These modifications are easy to control.…”

Section: Resultsmentioning

confidence: 99%

Photocrosslinking of Polyglycidol and Its Derivative: Route to Thermoresponsive Hydrogels

Utrata-Wesołek

Żymełka-Miara

Kowalczuk

et al. 2017

Photochem & Photobiology

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Hydrogels of biologically well-tolerated, high-molar-mass polyglycidol (PGl) and its thermoresponsive derivative poly(glycidol-co-ethyl glycidyl carbamate) have been obtained by direct UV crosslinking in the solid state. Polymers with molar masses up to 1.45 × 10 g mol were crosslinked in the presence of benzophenone or (4-benzoylbenzyl)trimethylammonium chloride as photosensitizers. The photosensitizer concentration was varied from 2 to 10 wt%. The influence of polymer composition and photosensitizer type and amount on the crosslinking efficiency, swelling and temperature behavior of the obtained hydrogels was investigated. The photocrosslinking of PGl and poly(glycidol-co-ethyl glycidyl carbamate) led to hydrogels with swelling degrees up to 1700%. The swelling degrees of the hydrogels decreased with the increase of the environmental temperature indicating the thermoresponsive nature of gels. The swelling of obtained gels can be controlled by varying the composition of the copolymer precursor and by the network density.

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“…10) [19]. It is known that by varying the degree of modification of polymer, it is possible to obtain temperature-responsive materials with tunable properties [20]. For all copolymer compositions studied C, initial polymer concentration 1 mass%, polymer molar mass 1,300,000 g/mol, 2 mass% BBTMAC, irradiation time 2 min.…”

Section: Cryogels From Water-soluble High Molar Mass Polymersmentioning

confidence: 99%

Cryogels via UV Irradiation

Petrov

Tsvetanov

2014

Polymeric Cryogels

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Hydrophobic modification of high molar mass polyglycidol to thermosensitive polymers

Cited by 47 publications

References 32 publications

Backbone‐Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3‐Methyl‐3‐(hydroxymethyl)oxetane

Backbone‐Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3‐Methyl‐3‐(hydroxymethyl)oxetane

Photocrosslinking of Polyglycidol and Its Derivative: Route to Thermoresponsive Hydrogels

Cryogels via UV Irradiation

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