Hydrophilic polymeric matrices for enhanced transdermal drug delivery

A Novel Hydrophilic Adhesive Matrix with Self-Enhancement for Drug Percutaneous Permeation Through Rat Skin

“…Many studies have identified that PVP, as a kind of water soluble polymer with excellent biocompatibility and capacity of hydrogenbond formation, performs excellent drug compatibility and delivery property as support matrixes for controlled drug release (11)(12)(13). The hydrophilicity and high molecular weight of PVP can provide good biocompatibility, mechanical strength and viscosity as adhesive matrix materials, but small molecular plasticizers are needed because of the high T g of PVP (T g ≈176°C).…”

Adhesive properties: a critical issue in transdermal patch development

“…Besides the synthesis of new polymers [42], another strategy is based on the exploitation of the peculiarities of pharmaceutical excipients used with different purposes. Among them, polyvinylpyrrolidone (PVP) [43], poly(methyl methacrylate)s [44][45][46] or mixtures thereof [30,33,47] are commonly used because of their well-recognized biocompatibility and safety, even if additives [42,44,48] and/or chemical cross-linking agents [49] are required to provide them appropriate adhesive properties.…”

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

“…This PVP-PEG400 PSA has been designed for enhanced transdermal delivery of drugs, is compatible with drugs of different physicochemical properties, does not act as a barrier to drug diffusion and is non-toxic [31][32][33]. We have decided to apply a hydrophilic PSA in order to keep the hydrophilic nature of the skin delivery system and because this type of adhesives offers several advantages over the hydrophobic ones: improved skin adhesion, compatibility with a higher variety of drugs and excipients, and expanded capability to control/manipulate adhesion-cohesive properties [34].…”