Hydrophilic matrices: Application of Placket–Burman screening design to model the effect of POLYOX–carbopol blends on drug release

El-Malah, Yasser; Nazzal, Sami

doi:10.1016/j.ijpharm.2005.11.032

Cited by 45 publications

(24 citation statements)

References 21 publications

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“…This design investigates every input factor and arranges them on the Pareto chart based on the magnitude of its influence with positive or negative sign respectively (color and colorless) [10]. PB design screens large number of input factors and at the same time reduces the number of runs [11,12]. 't' statistic is determined by estimating the standard effect of each input factor.…”

Section: Spray Drying Processmentioning

confidence: 99%

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Exploring Polymeric Nano-Particles as Targeted Pulmonary Delivery of Rifampicin, Ethambutol and Ofloxacin against Inh-Resistant Tuberculosis

Patel¹

2017

JLPRR

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Present research focus on novel combination of Rifampicin, Ofloxacin and Ethambutol loaded polymeric nanoparticles for the effective eradication of isoniazid resistant species of Tuberculosis. The nanoparticles containing Rifampicin, Ethambutol and Ofloxacin were prepared by spray drying technique using biodegradable polymer PLGA through critical process as well as polymer attributes which were identified and screened using Plackett-Burman screening design. Partial least square equation generated using Minitab Software for processing parameters as flow rate-5ml/min, inlet temperature-60˚C, aspirator capacity-50, ultrasonication time 40 min, ultrasonic amplitude % 60, and product parameters like drug: polymer ratio 2:1, aerosil concentration 1%, Solvent (DCM: Ethanol) ratio 75:25 on critical responses i.e. particles size, encapsulation efficiency, and product yield. Diffusion study revealed that optimum formulation containing 2:1 drug to polymer ratio was able to sustain the release of drugs up to 12 hrs. Particles Size was found to be less than 100 nm with uniform spherical shape and good agreement using TEM analysis. The three drug combination showed significantly synergism (p 0.007) for isoniazid susceptible species during in-vitro antimicrobial assay prove better efficacy. Overall study explored potential use of polymeric particles as targeted delivery system for drug susceptible and isoniazid resistant tuberculosis treatment.

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Section: Spray Drying Processmentioning

confidence: 99%

“…Where, Y is the response, A0 is the constant, and A1 is the coefficients of the response [11] Characterization of drugs loaded polymeric nanoparticles.…”

Section: Spray Drying Processmentioning

confidence: 99%

Exploring Polymeric Nano-Particles as Targeted Pulmonary Delivery of Rifampicin, Ethambutol and Ofloxacin against Inh-Resistant Tuberculosis

Patel¹

2017

JLPRR

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“…According to the proposed model, 12 experiments were performed and a polynomial model was generated. Out of the seven variables, only two were proved to be significant [46].…”

mentioning

confidence: 95%

Factorial Design and Machine Learning Strategies: Impacts on Pharmaceutical Analysis

El-Azazy¹

2017

Spectroscopic Analyses - Developments and Applications

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Pharmaceutical analysis is going through an expeditious progress as the perception of 'multivariate data analysis' (MVA) becomes gradually more assimilated. Pharmaceutical analysis comprises a range of processes that covers both chemical and physical assessment of drugs and their formulations employing different analytical techniques. With the revolution in instrumental analysis and the huge amount of information produced, there must be an up-to-date data processing tool. The role of chemometrics then comes up. Multivariate analysis (MVA) has the capability of effectively drawing a complete picture of the investigated process. Moreover, MVA reproduces the arithmetic influence of variables and their interactions through a smaller number of trials, keeping both efforts and capitals. Spectrophotometry is among the most extensively used techniques in pharmaceutical analysis either direct (single component) or derivative (multicomponent). In addition to these recognized benefits, using chemometrics in conjunction with spectrophotometry affects three vital characteristics: accuracy, precision and robustness. The impact of hyphenation of spectrophotometric analytical techniques to chemometrics (experimental design and support vector machines) on analytical laboratory will be revealed. A theoretical background on the different factorial designs and their relevance is provided. Readers will be able to use this chapter as a guide to select the appropriate design for a problem.

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“…The impact of various factors like polymer concentration, drug loading, drug solubility, diluent, and ionic concentration on the release of the drug from the extended release formulations has been reported in the literature (29)(30)(31). In the development of extended release formulations, it becomes difficult to ascertain factors affecting the release of the drug from the extrudates.…”

Section: Introductionmentioning

confidence: 99%

Use of Placket–Burman Statistical Design to Study Effect of Formulation Variables on the Release of Drug from Hot Melt Sustained Release Extrudates

et al. 2010

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Abstract. The present paper was focused on exploiting Plackett-Burman design to screen the effect of nine factors-poly (ethylene oxide) molecular weight (X 1 ), poly (ethylene oxide) amount (X 2 ), ethylcellulose amount (X 4 ), drug solubility (X 5 ), drug amount (X 6 ), sodium chloride amount (X 7 ), citric acid amount (X 8 ), polyethylene glycol amount (X 9 ), and glycerin amount (X 11 ) on the release of drugs from the extended release extrudates, i.e., release rate and release mechanism. The experiments were carried out according to a nine-factor 12-run statistical model and subjected to an 8-h dissolution study in phosphate buffer pH 6.8. The significance of the model was indicated by the ANOVA and the residual analysis. Poly (ethylene oxide) amount, ethylcellulose amount and drug solubility had significant effect on the T90 values whereas poly (ethylene oxide) amount and ethylcellulose amount had significant effect on the n value.

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Hydrophilic matrices: Application of Placket–Burman screening design to model the effect of POLYOX–carbopol blends on drug release

Cited by 45 publications

References 21 publications

Exploring Polymeric Nano-Particles as Targeted Pulmonary Delivery of Rifampicin, Ethambutol and Ofloxacin against Inh-Resistant Tuberculosis

Exploring Polymeric Nano-Particles as Targeted Pulmonary Delivery of Rifampicin, Ethambutol and Ofloxacin against Inh-Resistant Tuberculosis

Factorial Design and Machine Learning Strategies: Impacts on Pharmaceutical Analysis

Use of Placket–Burman Statistical Design to Study Effect of Formulation Variables on the Release of Drug from Hot Melt Sustained Release Extrudates

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