Hydrophilic magnetic polymer latexes. 1. Adsorption of magnetic iron oxide nanoparticles onto various cationic latexes

Sauzedde, F.; Elaı̈ssari, Abdelhamid; Pichot, Christian

doi:10.1007/s003960050461

Cited by 271 publications

(144 citation statements)

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“…Based on their dramatic swelling and deswelling behaviors, these gels are being utilized for new potential applications in numerous fields including chemical transducers, 8 chemical separations, 9,10 drug deliveries, 11,12 and artificial organs. 13 From an application point of view, gels would be much favorable if they could response to several stimuli simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Swelling characteristics of poly(N‐isopropylmethacrylamide‐co‐itaconic acid) gels prepared in various conditions

Vakıflı

Demirel

Çaykara

2010

J of Applied Polymer Sci

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Thermo-and pH-sensitive gels composed of N-isopropylmethacrylamide (NIPMA) and itaconic acid (IA) were prepared by free-radical crosslinking copolymerization in poly(ethylene glycol) (PEG) solution at 22 C and in water at À22 C and at 22 C, which were called as the macroporous gel (MGel), the cryogel (CGel), and the conventional gel (NGel), respectively. The gels were characterized by the equilibrium swelling, interior morphology, and deswelling kinetics. With increasing temperature in water, the gels exhibit reentrant conformational phase transition. During this transition, the gels first deswell in the range of temperature between 5 and 29 C, then drastically reswell if temperature is monotonically increased. The reswelling of the collapsed gels occurs above 45 C. It was shown that the reentrant transition in poly(N-isopropylmethacrylamideco-itaconic acid) [poly(NIPMA-co-IA)] gels requires moderate temperature, so that the hydrophobic interactions between chains dominate the swelling process. Scanning electron micrographs revealed that the interior network structure of MGel is more porous compared with those of CGel and NGel. This more porous structure provided numerous water channels for water diffusion out of the matrix and, therefore, an improved response rate to the external temperature and pH changes during the deswelling process.

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Section: Introductionmentioning

confidence: 99%

Swelling characteristics of poly(N‐isopropylmethacrylamide‐co‐itaconic acid) gels prepared in various conditions

Vakıflı

Demirel

Çaykara

2010

J of Applied Polymer Sci

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“…26,27 For synthesis of SPIONs, 5 mmol of ferrous and 10 mmol of ferric ion solutions were blended. After adding 5 mL of ammonium hydroxide, stirring was allowed to continue for 10 minutes.…”

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confidence: 99%

Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups

Hong¹,

Lee²,

Lee³

et al. 2011

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with −O − groups, so-called bare SPIONs. Following this, they were modified with three different functional groups – hydroxyl (−OH), carboxylic (−COOH), and amine (−NH 2 ) groups – by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2′,7′-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation and cell interaction for drug delivery, cell culture, and cancer-targeting applications.

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“…Iron oxide nanoparticles were then adsorbed on the latexes via electrostatic interaction depending on the concentration and type of nanoparticles. The highest adsorption was achieved with pure cationic poly(N-isopropylacrylamide) latexes [152,153].…”

Section: Layer-by-layer Processmentioning

confidence: 93%

Preparation and properties of magnetic nano‐ and microsized particles for biological and environmental separations

Horák¹,

Babič²,

Macková³

et al. 2007

J of Separation Science

318

177

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The paper presents a critical overview on magnetic nanoparticles and microspheres used as separation media in different fields of chemistry, biochemistry, biology, and environment protection. The preparation of most widely used magnetic iron oxides in appropriate form, their coating or encapsulation in polymer microspheres, and functionalization is discussed in the first part. In the second part, new developments in the main application areas of magnetic composite particles for separation and catalytical purposes are briefly described. They cover separations and isolations of toxic inorganic and organic ions, proteins, and other biopolymers, cells, and microorganisms. Only selected number of relevant papers could be included due to the restricted extent of the review.

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Hydrophilic magnetic polymer latexes. 1. Adsorption of magnetic iron oxide nanoparticles onto various cationic latexes

Cited by 271 publications

References 1 publication

Swelling characteristics of poly(N‐isopropylmethacrylamide‐co‐itaconic acid) gels prepared in various conditions

Swelling characteristics of poly(N‐isopropylmethacrylamide‐co‐itaconic acid) gels prepared in various conditions

Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups

Preparation and properties of magnetic nano‐ and microsized particles for biological and environmental separations

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