Hydronephrosis and Renal Deterioration in the Elderly due to Abnormalities of the Lower Urinary Tract and Ureterovesical Junction

The association between benign prostatic hyperplasia and chronic kidney disease in community-dwelling men

“…Men with chronic urinary retention often have increased bladder pressures, decreased bladder compliance, and detrusor instability, all of which have been directly associated with renal failure [6][7][8]. The bladder wall thickening that leads to a decline in bladder compliance can result in a functional or mechanical obstruction at the ureterovesicular junction [32]. However, evaluation for upper tract dilatation (hydronephrosis) was not done in this study.…”

“…A possible mechanistic pathway by which BPH leads to chronic kidney disease could be an obstructive uropathy at the uretero-vesicular junction [32]. Chronic urinary retention leads to bladder wall thickening with trabeculations via smooth muscle hypertrophy and connective tissue infiltrates [25].…”

Effect of post-voiding urine volume on progression of renal function decline in patients with type 2 diabetes

“…We have used the presence of PVR > 100 mL as a diagnostic sign of DBD and it is associated with a rapid decline in renal function. One possible mechanistic pathway by which DBD could lead to GFR decline is an obstructive uropathy [27]. Urine retention along any part of the urinary tract increases the risk of stone formation, infection, and, ultimately, urinary tract injury.…”

Shock wave lithotripsy for ureteral stones in elderly male patients

“…Elderly patients and patients with prostatic cancer treated with antiandrogen medications may have osteoporosis, hence over-stretching during positioning might also cause trauma to the spine [9]. Although never studied before, prostatic hyperplasia and obstructive voiding symptoms may have an effect on spontaneous stone expulsion ability [10].…”