Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine

Takahashi, Toru; Yokawa, Takeo; Ishihara, Noriyuki; Ōkubo, Tsutomu; Chu, Djong-Chi; Nishigaki, Eri; Kawada, Yuka; Kato, Masako; Juneja, Lekh Raj

doi:10.1016/j.nutres.2009.05.013

Cited by 34 publications

(21 citation statements)

References 18 publications

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“…Glucose absorption, roughly estimated as (glucose concentration in artificial digesta before infusion)/(glucose concentration in artificial digesta at slaughter, 80 min), was 0.83 for the control and 0.70 for the cellulose-addition group. The depressed glucose diffusion rate was confirmed in the intestinal lumen with higher digesta viscosity after adding water-insoluble (Takahashi et al unpublished data) and water-soluble fiber (43). These data support the notion that glucose behavior in the lumen is a rate-limiting factor in glucose absorption.…”

Section: Control Of Postprandial Blood Glucose Level By Increasing DIsupporting

confidence: 55%

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Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

Takahashi

2011

J Nutr Sci Vitaminol

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Summary Digesta flow-behavior types in the intestinal lumen, such as turbulent and laminar flow, should define modes of digestion and absorption. This review presents a simulation of flow behavior in the intestinal lumen and discusses the behavior of nutrients and enzymes in the intestinal lumen under laminar-flow conditions. The significance of digesta viscosity for glucose and water absorption and digestion and fermentation in the intestine is also discussed.

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Section: Control Of Postprandial Blood Glucose Level By Increasing DIsupporting

confidence: 55%

“…(equation 13) Hence, digesta viscosity is a major modulator of nutrient absorption rate (1,2,19,42,43).…”

Section: Behavior Of Nutrients In the Intestinal Lumenmentioning

confidence: 99%

Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

Takahashi

2011

J Nutr Sci Vitaminol

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“…[31][32][33][34][35][36] Among them, indigestible dextrin has been confirmed to suppress the postprandial increase in blood glucose level by inhibiting α-glucosidase 35) and it is widely used as a food for specified health use and as a functional food. It seems reasonable to consider that Ca-Alg works similarly.…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 99%

Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats

Idota

Katō

Shiragami

et al. 2018

Biological & Pharmaceutical Bulletin

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“…It has been reported that these two polymers have protective effect against inflammation in GIT (31,32). Guar gum, as a watersoluble fiber, has been reported to have beneficial effect in bowel-related ailments such as diverticulosis, Crohn's disease, colitis, and irritable bowel syndrome (33). The C-glycosylated and sulfated derivatives of guar gum have been shown to have anti-inflammatory activity (34).…”

Section: Discussionmentioning

confidence: 99%

I n Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model

et al. 2015

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Abstract. Colonic drug delivery is intended not only for local treatment in inflammatory bowel disease (IBD) but also for systemic delivery of therapeutics. Intestinal myeloperoxidase (MPO) determination could be used to estimate the average level of inflammation in colon as well as to determine the efficacy of drugs to be used in the treatment of inflammatory bowel diseases or study the specificity of dosage forms to be used for colonic targeting of anti-inflammatory drugs. Colonic prodrug sulfasalazine (SASP) gets metabolized to give 5-aminosalicylic acid (5-ASA), which is the active portion of SASP. However, when given orally, 5-ASA is absorbed in upper part of gastrointestinal tract (GIT) and not made available in colon. In the present study, colon-targeted delivery of 5-ASA was achieved by formulating tablets with two natural polymers namely guar gum and pectin using compression coating method. Colonic specificity of 5-ASA tablets (prepared using guar gum and pectin as polymers) was evaluated in vitro using simulated fluids mimicking in vivo environment as well as in vivo method using chemically (2,4,6-trinitrobenzenesulfonic acid and acetic acid)-induced colitis rat model. Both colon-specific formulations of 5-ASA (guar gum and pectin) were observed to be more effective in reducing inflammation in chemically induced colitis rat models when compared to colon-specific prodrug sulfasalazine as well as conventional 5-ASA administered orally.

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Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine

Cited by 34 publications

References 18 publications

Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats

I n Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model

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