Hydrolytic Stability of Saccharin

Degarmo, Oliver; Ashworth, George W.; Eaker, Charles M.; Munch, Ralph H.

doi:10.1002/jps.3030410108

Cited by 13 publications

(3 citation statements)

References 2 publications

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“…Since saccharin has a hydrolytic stability during gastrointestinal absorption (DeGarmo et al, 1952), we assumed that there was no body clearance during the short term incubation time.…”

Section: Treatment Of Asmentioning

confidence: 99%

Modified Apolipoprotein (apo) A-I by Artificial Sweetener Causes Severe Premature Cellular Senescence and Atherosclerosis with Impairment of Functional and Structural Properties of apoA-I in Lipid-Free and Lipid-Bound State

Jang

Jeoung

Cho

2011

Molecules and Cells

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Long-term consumption of artificial sweeteners (AS) has been the recent focus of safety concerns. However, the potential risk of the AS in cardiovascular disease and lipoprotein metabolism has not been investigated sufficiently. We compared the influence of AS (aspartame, acesulfame K, and saccharin) and fructose in terms of functional and structural correlations of apolipoprotein (apo) A-I and high-density lipoproteins (HDL), which have atheroprotective effects. Long-term treatment of apoA-I with the sweetener at physiological concentration (3 mM for 168 h) resulted in loss of antioxidant and phospholipid binding activities with modification of secondary structure. The AS treated apoA-I exhibited proteolytic cleavage to produce 26 kDa-fragment. They showed pro-atherogenic properties in acetylated LDL phagocytosis of macrophages. Each sweetener alone or sweetener-treated apoA-I caused accelerated senescence in human dermal fibroblasts. These results suggest that long-term consumption of AS might accelerate atherosclerosis and senescence via impairment of function and structure of apoA-I and HDL.

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“…Since saccharin has a hydrolytic stability during gastrointestinal absorption (DeGarmo et al, 1952), we assumed that there was no body clearance during the short term incubation time.…”

Section: Treatment Of Asmentioning

confidence: 99%

Modified Apolipoprotein (apo) A-I by Artificial Sweetener Causes Severe Premature Cellular Senescence and Atherosclerosis with Impairment of Functional and Structural Properties of apoA-I in Lipid-Free and Lipid-Bound State

Jang

Jeoung

Cho

2011

Molecules and Cells

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“…Tandem ring-opening/esterification of nitrosaccharin 15 yielded sulfonamide 16. 27 Palladium-catalyzed hydrogenation of this compound, followed by diazotization/copper-mediated aqueous decomposition of diazonium salt, furnished phenol 12 in good overall yield. Its alkylation provided O -benzylated sulfonamide 18.…”

Section: Resultsmentioning

confidence: 98%

Synthetic approach to iodosulfuron-methyl and metsulfuron-methyl metabolites and their application for water analysis

Rakowiecki,

Studzińska,

Ścianowski

et al. 2024

RSC Adv.

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“…Extraction of the acid-hydrolyzed sample into diethyl ether could solubilize some saccharin. However, the acid hydrolysis step in the multiphenol method is adequate to convert most of the saccharin to the ammonium o-carboxybenzenesulfonate (DeGarmo et al, 1952). Subsequent columning on silica gel retains saccharin and the ammonium ocarboxybenzenesulfonate.…”

Section: Resultsmentioning

confidence: 99%

Identification of N-methylsaccharin as a peak at the retention time of methylated (2,4,5-trichlorophenoxy)acetic acid in human urinary exposure samples

Kirby¹,

Hetzler²,

Slach³

et al. 1982

J. Agric. Food Chem.

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Hydrolytic Stability of Saccharin

Cited by 13 publications

References 2 publications

Modified Apolipoprotein (apo) A-I by Artificial Sweetener Causes Severe Premature Cellular Senescence and Atherosclerosis with Impairment of Functional and Structural Properties of apoA-I in Lipid-Free and Lipid-Bound State

Modified Apolipoprotein (apo) A-I by Artificial Sweetener Causes Severe Premature Cellular Senescence and Atherosclerosis with Impairment of Functional and Structural Properties of apoA-I in Lipid-Free and Lipid-Bound State

Synthetic approach to iodosulfuron-methyl and metsulfuron-methyl metabolites and their application for water analysis

Identification of N-methylsaccharin as a peak at the retention time of methylated (2,4,5-trichlorophenoxy)acetic acid in human urinary exposure samples

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