Hydrolytic stability of polyurethane medical adhesive dressings

Pavlova, M.; Draganova, M.

doi:10.1016/0142-9612(94)90198-8

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…Ageing of polyurethane adhesives is rarely studied. The few reported results indicate a good stability of the urethane groups, as shown in [21] for medical poly(ether urethane) adhesive in distilled water or physiological solution at 20 °C and 100 °C, respectively. In summary, the ageing behaviour of poly(ether urethane) deserves further attention.…”

Section: Introductionmentioning

confidence: 95%

Ageing mechanisms of polyurethane adhesive/steel interfaces

Weiß

Voigt

Kunze

et al. 2016

International Journal of Adhesion and Adhesives

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Section: Introductionmentioning

confidence: 95%

Ageing mechanisms of polyurethane adhesive/steel interfaces

Weiß

Voigt

Kunze

et al. 2016

International Journal of Adhesion and Adhesives

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“…In our study, a new polyurethane composite is investigated for its potential as a filler in critical-sized bone defects. Polyurethane has a long history within in vivo application, such as artificial heart valves [ 44 , 45 , 46 , 47 ]. It is a non-toxic material that induces little or no negative effects in a living body [ 48 , 49 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of Flexible Polyurethane/Poly l-Lactic Acid Composite Scaffold as a Potential Filler for Bone Regeneration

Lui

2017

Materials

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Degradable bone graft substitute for large-volume bone defects is a continuously developing field in orthopedics. With the advance in biomaterial in past decades, a wide range of new materials has been investigated for their potential in this application. When compared to common biopolymers within the field such as PLA or PCL, elastomers such as polyurethane offer some unique advantages in terms of flexibility. In cases of bone defect treatments, a flexible soft filler can help to establish an intimate contact with surrounding bones to provide a stable bone-material interface for cell proliferation and ingrowth of tissue. In this study, a porous filler based on segmented polyurethane incorporated with poly L-lactic acid was synthesized by a phase inverse salt leaching method. The filler was put through in vitro and in vivo tests to evaluate its potential in acting as a bone graft substitute for critical-sized bone defects. In vitro results indicated there was a major improvement in biological response, including cell attachment, proliferation and alkaline phosphatase expression for osteoblast-like cells when seeded on the composite material compared to unmodified polyurethane. In vivo evaluation on a critical-sized defect model of New Zealand White (NZW) rabbit indicated there was bone ingrowth along the defect area with the introduction of the new filler. A tight interface formed between bone and filler, with osteogenic cells proliferating on the surface. The result suggested polyurethane/poly L-lactic acid composite is a material with the potential to act as a bone graft substitute for orthopedics application.

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