Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol–polycaprolactone-based polyurethanes

Morales-González, María; Díaz, Luis Eduardo; Sans, J. A.; Vilariño-Feltrer, Guillermo; Gómez-Tejedor, José A.; Valero, Manuel

doi:10.1557/jmr.2020.303

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…The addition of starch (native and zwitterionic) was made after crosslinking with PE and homogenizing the powder in the media at 70 °C and 300 rpm for 15 min [ 31 ]. Films of polyurethane composites were obtained when the composite was poured into a stainless steel mold and cured at 110 °C for 12 h [ 32 ]. The composition in the weight of polyols and starch (native and zwitterionic) is exhibited in Table 1 , where composition P1 corresponds to 5% PEG—90% PCL—5% PE, composition P2 corresponds to 45% PEG—45% PCL—10% PE and composition P3 corresponds to 46.25% PEG—46.25% PCL—7.5% PE.…”

Section: Methodsmentioning

confidence: 99%

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Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

2022

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Improvements in the antithrombogenicity activity of biomaterials for cardiovascular applications are necessary to meet the demand for vascular grafts in the world. Zwitterionic compounds tend to be used due to their anti-fouling properties, which reduce platelet adhesions and protein absorptions. Therefore, in this research, potato starch (AL-N) and zwitterionic starch (AL-Z) (obtained by Williamson etherification) were included as fillers in polyurethane (PU) matrices from polycaprolactone diol (PCL), polyethylene glycol (PEG), pentaerythritol (PE) and isophorone diisocyanate (IPDI) in order to study their effect in terms of their physicochemical, mechanical and thermal properties. We conducted our evaluation using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), contact angle analysis, swelling behavior, thermogravimetric analysis (TGA), tensile/strain analysis, scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (SEM-EDS), dynamic mechanic analysis (DMA), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The results showed that AL-N and AL-Z modified these properties, where AL-N improved tensile strength, and AL-Z increased the hydrophilicity of polyurethanes matrices; additionally, AL-N had interactions with the soft segments, and AL-Z had interactions with the hard segments. Finally, both fillers reduced the degree of crystallinity and did not affect the thermal stability of polyurethanes.

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Section: Methodsmentioning

confidence: 99%

“…Water absorption was studied by the weight of the material before (W0) and after soaking in distilled water (WSx) at different times. Four points on the first day and three points per day in the next three days were recorded [ 32 , 33 ]. Equation (2) was used to determine the percentage of water absorption.…”

Section: Methodsmentioning

confidence: 99%

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

2022

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“…Samples of the composite materials of 6 mm in diameter (sterilized in UV radiation for 1 h and stabilized in SmGM-2 culture medium for 24 h) were placed in the wells of a 96-well plate with an AoSMC suspension at a density of 4 × 10 5 cell per mL and incubated at 37 °C with 5% CO 2 for 24 h. An aliquot of 50 µL per sample was taken and deposited in another 96-well plate to measure the LDH released following the protocol of the CytoTox 96 ® Non-Radioactive Cytotoxicity Assay kit [ 25 ]. Cell viability of HUVECs was measured following the same protocol.…”

Section: Methodsmentioning

confidence: 99%

“…Our laboratory previously studied polyurethanes for cardiovascular applications, where they evaluated the influence of composition on the physic–mechanical and biological performance of PCL-PEG-PE polyurethanes [ 23 , 24 , 25 ]. Based on that work, we selected the compositions with the best biological [ 25 ] and biomechanical performance [ 23 ] to fabricate the composites presented in this work. Moreover, we characterized the chemical and mechanical properties of the polyurethane–starch composite [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Anti-Thrombogenic Activity of Polyurethane Starch Composites

Cespedes

Díaz

Valero

2022

JFB

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The increasing morbidity and mortality of patients due to post-surgery complications of coronary artery bypass grafts (CABPG) are related to blood–material interactions. Thus, the characterization of the thrombogenicity of the biomaterial for cardiovascular devices is of particular interest. This research evaluated the anti-thrombogenic activity of polyurethanes–starch composites. We previously synthesized polyurethane matrices that were obtained from polycaprolactone diol (PCL), polyethylene glycol (PEG), pentaerythritol (PE), and isophorone diisocyanate (IPDI). In addition, potato starch (AL-N) and zwitterionic starch (AL-Z) were added as fillers. The anti-thrombogenic property was characterized by the clot formation time, platelet adhesion, protein absorption, TAT complex levels, and hemolysis. Additionally, we evaluated the cell viability of the endothelial and smooth muscle cells. Statically significant differences among the polyurethane matrices (P1, P2, and P3) were found for protein absorption and the blood clotting time without fillers. The polyurethanes composites with AL-Z presented an improvement in the anti-thrombogenic property. On the other hand, the composites with AL-Z reduced the viability of the endothelial cells and did not significantly affect the AoSCM (except for P1, which increased). These results classify these biomaterials as inert; therefore, they can be used for cardiovascular applications.

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“…Therefore, its versatility is wide, as the quantities and ratios of the polyols and isocyanates used can be adjusted [ 8 ]. The biocompatibility and biostability of polyurethanes make them promising for application in the biomedical and clinical fields, which has led to recent increasing demand for them [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

et al. 2022

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Dressings made with polyurethanes have been found to exhibit good and varied biological properties that make them good candidates for this application. However, as has been seen, the wound-healing process is complex, which includes four different stages. So far, the design and evaluation of polyurethane for wound dressing has focused on achieving good properties (mechanical, physicochemical, and biological), but each of them separates from the others or even directed at only one of the stages of skin wound-healing. Therefore, the aim of this systematic review is to explore the applications of polyurethanes in wound dressings and to determine whether could be designed to cover more than one stage of skin wound-healing. The PRISMA guidelines were followed. The current research in this field does not consider each stage separately, and the design of polyurethane dressings is focused on covering all the stages of wound healing with a single material but is necessary to replace polyurethanes in short periods of time. Additionally, little emphasis is placed on the hemostasis stage and further characterization of polyurethanes is still needed to correlate mechanical and physicochemical properties with biological properties at each stage of the wound-healing. Current research demonstrates an effort to characterize the materials physiochemically and mechanically, but in terms of their biological properties, most of the literature is based on the performance of histological tests of explants morphologically probing the compromised tissues, which give an indication of the potential use of polyurethanes in the generation of wound-healing dressings.

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Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol–polycaprolactone-based polyurethanes

Abstract: Abstract

Cited by 5 publications

References 38 publications

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

Influence of Starch on the Structure–Properties Relationship in Polyethylene Glycol/Polycaprolactone Diol Polyurethanes

Assessment of the Anti-Thrombogenic Activity of Polyurethane Starch Composites

Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review

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