Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

Loo, Say Chye Joachim; Tan, Wei Li Jason; Khoa, Shu Min; Chia, N. K.; Venkatraman, Subbu S.; Boey, Freddy Yin Chiang

doi:10.1016/j.ijpharm.2008.04.017

Cited by 27 publications

(8 citation statements)

References 11 publications

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“…The accelerated degradation of PLLA in S2 particles was believed to be caused by the migration of degraded acidic oligomers of PLGA into PLLA layer. These oligomers increased the hydrophilicity and acidity of the PLLA layer thereby increasing water ingress (Figure S4) to facilitate hydrolytic cleavage of the PLLA chains . Hence, after complete degradation of PLGA shell, remaining PLLA layer continued to degrade by ester hydrolysis as observed by GPC analysis (Figure ).…”

Section: Resultsmentioning

confidence: 99%

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

Biswal¹,

Saha²

2019

J of Applied Polymer Sci

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This study provides an insight about the mechanism of formation of tri‐layered (instead of bilayers) particles originated from two biodegradable polymers by emulsion solvent evaporation method. It was also demonstrated how layer configurations of tri‐layered particles composed of poly(l‐lactide) (PLLA) and poly(d,l‐lactide‐co‐glycolide) (PLGA), can be changed from kinetically trapped to thermodynamically favorable structures (dictated by spreading coefficient theory) by tweaking several solution parameters. Layer switching, core, and shell thickness manipulation can also be achieved. Interestingly, among the various configurations, tri‐layered particles made with PLGA of intermediate viscosity and PLLA of high viscosity were found to provide controlled and sustainable release profiles for dual actives such as antibacterial (benzoic acid) and antioxidant (tocopherol) with appreciably high release rates. The dual activity of these particles was tested by incorporating them in chicken broth medium and found to provide excellent antibacterial as well as antioxidant activity for extended period of time (>20 days). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48009.

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Section: Resultsmentioning

confidence: 99%

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

Biswal¹,

Saha²

2019

J of Applied Polymer Sci

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“…A number of studies have carried out to optimize of hydrolysis of polyesters and their drug delivery profiles. [2][3][4][5][6] Large number implantable drug delivery devices have been developed over the years. The implants can be introduced by different shapes: films, rods, discs, pellets, and plugs.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Progesterone and Lidocaine Hydrochloride Release from Poly(L-lactide) Films

Mashak¹,

Mobedi²,

Mahdavi³

2015

Pharm Sci

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“…Compared to particle delivery systems, removing an implant microfilm from an eye would allow easy reversal of unwanted side effects. Furthermore, a polymeric implant has the capability of loading more drugs in weight, and can be fabricated into various dimensions to modulate the amount and duration of drug release [23]. The use of a biodegradable polymeric implant to deliver a sustained drug level in the eye is therefore an attractive option.…”

Section: Introductionmentioning

confidence: 99%

A Biodegradable, Sustained-Released, Prednisolone Acetate Microfilm Drug Delivery System Effectively Prolongs Corneal Allograft Survival in the Rat Keratoplasty Model

et al. 2013

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Frequent and long-term use of topical corticosteroids after corneal transplantation is necessary to prevent graft rejection. However, it relies heavily on patient compliance, and sustained therapeutic drug levels are often not achieved with administration of topical eye drops. A biodegradable drug delivery system with a controlled and sustained drug release may circumvent these limitations. In this study, we investigated the efficacy of a prednisolone acetate (PA)-loaded poly (d,l-lactide-co-ε-caprolactone) (PLC) microfilm drug delivery system on promoting the survival of allogeneic grafts after penetrating keratoplasty (PK) using a rat model. The drug release profiles of the microfilms were characterized (group 1). Subsequently, forty-eight PK were performed in four experimental groups: syngeneic control grafts (group 2), allogeneic control grafts (group 3), allogeneic grafts with subconjunctivally-implanted PA microfilm (group 4), and allogeneic grafts with PA eye drops (group 5; n = 12 in each). PA-loaded microfilm achieved a sustained and steady release at a rate of 0.006–0.009 mg/day, with a consistent aqueous drug concentration of 207–209 ng/ml. The mean survival days was >28 days in group 2, 9.9±0.8 days in group 3, 26.8±2.7 days in group 4, and 26.4±3.4 days in group 5 (P = 0.023 and P = 0.027 compared with group 3). Statistically significant decrease in CD4+, CD163+, CD 25+, and CD54+ cell infiltration was observed in group 4 and group 5 compared with group 3 (P<0.001). There was no significant difference in the mean survival and immunohistochemical analysis between group 4 and group 5. These results showed that sustained PA-loaded microfilm effectively prolongs corneal allograft survival. It is as effective as conventional PA eye drops, providing a promising clinically applicable alternative for patients undergoing corneal transplantation.

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Hydrolytic degradation characteristics of irradiated multi-layered PLGA films

Cited by 27 publications

References 11 publications

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

A Comparative Study of Progesterone and Lidocaine Hydrochloride Release from Poly(L-lactide) Films

A Biodegradable, Sustained-Released, Prednisolone Acetate Microfilm Drug Delivery System Effectively Prolongs Corneal Allograft Survival in the Rat Keratoplasty Model

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