A Comparative Study of Progesterone and Lidocaine Hydrochloride Release from Poly(L-lactide) Films

Mashak, Arezou; Mobedi, Hamid; Mahdavi, Hamid

doi:10.15171/ps.2015.21

Cited by 14 publications

(20 citation statements)

References 26 publications

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“…One ml of each formulation was poured on dialysis membrane with a molecular weight cut off 12000 Da and placed in a beaker containing 50 ml of PBS (pH 7.4) at 37°C. The amount of released drug in PBS media was determined by an ultraviolet spectrophotometer (mini 1240, Shimadzu, Japan) at λ max = 430 nm [30, 32]. The standard curve of sunitinib in PBS was linear over the concentration range of 0.45–20.0 µg/ml.…”

Section: Methodsmentioning

confidence: 99%

Poly(glycerol sebacate) nanoparticles for ocular delivery of sunitinib: physicochemical, cytotoxic and allergic studies

Chegini

Varshosaz

Sadeghi

et al. 2019

IET nanobiotechnol.

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Poly(glycerol sebacate) (PGS) is a new biodegradable polymer with good biocompatibility used in many fields of biomedicine and drug delivery. Sunitinib-loaded PGS/gelatine nanoparticles were prepared by the de-solvation method for retinal delivery and treatment of diabetic retinopathy. The nanoparticles were characterised by Fourier-transform infrared and differential scanning calorimetry. The effects of different formulation variables including drug-to-carrier ratio, gelatine-to-PGS ratio, and glycerine-to-sebacate ratio were assessed on the encapsulation efficiency (EE%), particle size, release efficiency (RE), and zeta potential of the nanoparticles. The in vitro cytotoxicity of PGS/gelatine nanoparticles was studied on L929 cells. Draize test on rabbit eyes was also done to investigate the possible allergic reactions caused by the polymer. Glycerine/sebacic acid was the most effective parameter on the EE and RE. Gelatine-to-PGS ratio had the most considerable effect on the particle size while the RE was more affected by the glycerine/sebacic acid ratio. The optimised formulation (S 1 G 0.7 D 21.2) exhibited a particle size of 282 nm, 34.6% EE, zeta potential of −8.9 mV, and RE% of about 27.3% for drug over 228 h. The 3-(4,5dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide assay indicated PGS/gelatine nanoparticles were not cytotoxic and sunitinib-loaded nanoparticles were not toxic at concentrations <36 nM.

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Section: Methodsmentioning

confidence: 99%

Poly(glycerol sebacate) nanoparticles for ocular delivery of sunitinib: physicochemical, cytotoxic and allergic studies

Chegini

Varshosaz

Sadeghi

et al. 2019

IET nanobiotechnol.

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“…The formed carboxylic acid during the hydrolytic scission of ester bonds could further auto‐catalyze the process. Consequently, the hydrolysis rate was accelerated exponentially . On the other hand, the formation of acidic regions of the microclimates was influenced by the presence of HA nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

PLGA‐based in situ‐forming system: degradation behavior in the presence of hydroxyapatite nanoparticles

Radfar

Mobedi

Behnamghader

et al. 2019

Polymer Engineering & Sci

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The degradation behavior of poly(lactic‐co‐glycolic acid) (PLGA) is important for its application as a biomaterial. In this work, the influence of nano‐hydroxyapatite (nano‐HA) on the degradation behavior of PLGA matrix was studied. PLGA‐based in situ forming system containing nano‐HA was prepared using the immersion precipitation method and the polymer hydrolysis was investigated in a phosphate buffer (pH 7.4) at 37°C. The pH values in the testing medium were evaluated to quantify the degradation process. Gel permeation chromatography and scanning electron microscopy techniques were employed to monitor changing of the weight‐average molecular weight (MW) and the body structures of PLGA matrices, respectively. To model the MW changes, a first‐order degradation model was employed. The formed PLGA matrices had different porosities that effected water penetration into the matrices following the hydrolysis process. The obtained degradation rate constant using a mathematical model for PLGA matrices with different nano‐HA content was about from 2.5 to 4.5 times lower than neat PLGA matrix. POLYM. ENG. SCI., 59:1028–1035, 2019. © 2019 Society of Plastics Engineers

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“…When 0.5 < n < 1, diffusion- erosion is the dominant mechanism of drug release. If n value is close to 1, the drug release is mainly controlled by erosion (or relaxation) ( 12 13 ).…”

Section: Methodsmentioning

confidence: 99%

Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles

et al. 2017

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Inhalable dry powders containing poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were developed for the delivery of tadalafil (TAD) for treatment of life-treating pulmonary arterial hypertension. Taguchi design was employed to evaluate the effects of different formulation variables on the physicochemical characteristics of PLGA-NPs prepared using emulsion solvent evaporation method. Inhalable PLGA-NPs of TAD were successfully prepared by co-spray drying the PLGA-NPs with inert carriers. Physicochemical characteristics and in vitro deposition of the aerosolized drug were also evaluated. The optimized formulation was prepared using 7.5 mg of PLGA, 2.5 mg of TAD, sonication time of 6 min and 2% polyvinyl alcohol (PVA) as the stabilizer. The optimized aqueous/oil phase ratio for PLGA-NPs preparation was 10:1. Polymer/drug ratio was the most effective parameter on the release efficiency. Encapsulation efficiency, zeta potential and particle size of PLGA-NPs were more affected by aqueous/organic phase ratio. The spray dried powders containing PLGA-NPs had a mass median aerodynamic diameter (MMAD) in the range of 1.4–2.8 μm that was suitable for TAD delivery to the deep region of lung. The presence of L- leucine in mannitol containing formulations decreased the interparticulate forces between particles and increased significantly the process yield and fine particle fraction (FPF). The results indicated that prepared dry powders containing TAD-loaded PLGA-NPs were suitable for inhalation and has the potential for the treatment of pulmonary arterial hypertension.

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A Comparative Study of Progesterone and Lidocaine Hydrochloride Release from Poly(L-lactide) Films

Cited by 14 publications

References 26 publications

Poly(glycerol sebacate) nanoparticles for ocular delivery of sunitinib: physicochemical, cytotoxic and allergic studies

Poly(glycerol sebacate) nanoparticles for ocular delivery of sunitinib: physicochemical, cytotoxic and allergic studies

PLGA‐based in situ‐forming system: degradation behavior in the presence of hydroxyapatite nanoparticles

Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles

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