Hydrolysis of dinucleoside phosphates – mRNA 5′ cap analogues – promoted by a binuclear copper(II)–zinc(II) complex

A Novel Dinucleating Ligand-Containing Hexabenzimidazoles and Its Dinuclear Zinc Complex Bridged by a Carboxylate Group for the Hydrolysis of 2-Hydroxypropyl-p-nitrophenyl phosphate

“…Two triplets at 2.92 and 2.46 arise due to the methylene protons a and b, respectively. The FAB-Mass spectrum of the LNa in aqueous acetone (50%) showed a molecular peak at m/z 1167 (supporting information), corresponding to the anionic part of the ligand L. Upon complexation, an increase in the benzimidazole frequencies were observed, which is in accordance with the coordination of the ligand through the benzimidazolyl nitrogens [23][24][25]. The frequencies of the amides I and II have not been affected.…”

“…There have been many research efforts to design and synthesize mononuclear zinc(II) complexes for promoting the hydrolysis of 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP) [23][24][25][26], and a simple strategy for the design of dinuclear catalysts is to connect two mononuclear zinc ligands by a short tether. Cooperative interaction between metal ions can be promoted by incorporation of functionality within the tether, which will allow it to serve as a scaffold for chelation of the two metal ions [27].…”

Phosphodiester hydrolysis and specific DNA binding and cleavage promoted by guanidinium-functionalized zinc complexes

“…Nature has selected an impressive array of metalloenzymes, often with one or more coordinated metal ions at their active sites that catalyze efficiently the hydrolytic cleavage of such bonds to sustain life [5][6][7][8][9][10]. Many zinc complexes are known to be synthetic hydrolases towards the phosphodiester cleavage of DNA [5,6,[11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Among the various model complexes, the Zn(II) complexes incorporating functional groups, such as the carboxyl groups of aspartate residue, or the guanidinium/amino groups of arginine residue, or many other organic groups belonging to the amino acid residue side chains, have been shown to hydrolyze phosphodiester at reasonably faster rates [18,[20][21][22]24].…”

Imidazolate-bridged dicopper(II) and copper(II)–zinc(II) complexes of macrocyclic ligand with methylimidazol pendants: Model study of copper(II)–zinc(II) superoxide dismutase

“…Ever since the X-ray crystal structure analysis revealed the existence of imidazolate-bridged copper-zinc heterodinuclear structure in the active center of the bovine erythrocyte Cu 2 Zn 2 -SOD, a number of imidazolate-bridged dinuclear complexes have been synthesized [8][9][10][11][12]. Comparison between [Cu 2 (TMDT) 2 (im)] 3+ (TMDT = 1, 1, 7, 7-tetramethyldiethylenetriamine) and [Cu 2 (bpim)] 3+ (bpim À = 4,5-bis[2-(2-pyridyl)-ethyliminomethyl]imidazolate) revealed that the imidazolate bridge in the former is stable only over a narrow pH range while the one in the latter is quite stable [13,14].…”