Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19

Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID‐19 patient

“… 1 , 7 , 8 , 9 It is hypothesized that H 2 therapy may decrease inflammation by decreasing the cytokine storm and by reducing free radical‐induced damage, which may decrease hypoxia and delay the need for oxygen therapy. 7 , 8 , 9 , 10 , 11 , 12 This hypothesis has led to the initiation of a large‐scale multicenter trial in Europe utilizing hydrogen‐producing tablets in high‐risk patients undergoing ambulatory care. 13 The concept that molecular hydrogen may be a beneficial treatment for severe COVID‐19 is supported by a small trial in China that reported hydrogen inhalation was effective for reducing disease severity and dyspnea.…”

Molecular Hydrogen as an Adjuvant Therapy May be Associated with Increased Oxygen Saturation and Improved Exercise Tolerance In a COVID-19 patient

“…Hydrogen may induce the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, thereby exerting cytoprotective activity resulting in decreased damage to cells caused by SARS-CoV-2 infection. 1,8,14 It is also possible that SARS-CoV-2 induces activation of apoptosis and protein 53 (p53) signaling pathway in lymphocytes, and hydrogen could exert anti-apoptotic effects in lymphocytes by decreasing p53. This may reduce disease progression and be used for prevention and treatment in COVID-19 patients.…”

“…This may reduce disease progression and be used for prevention and treatment in COVID-19 patients. 8 Hydrogen supplementation can suppress the elevation of pro-inflammatory proteins (e.g., tumor necrosis factor-a, IL-1b, IL-6, IL-10 and intercellular cell adhesion molecule-1) via nuclear factor kappa-light chain-enhancer of activated B cells (NFκB) pathway. 8 It is known that these pro-inflammatory cytokines are overexpressed in COVID-19 infection and they play important roles in the progression of multi-organ failure.…”

“…6 Recently, molecular hydrogen (H 2 ) has been suggested for the treatment of COVID-19, due to its potential antioxidant and anti-inflammatory effects. 7,8 It is hypothesized that H 2 therapy may decrease inflammation by decreasing the cytokine storm and by reducing free radical-induced damage, which may decrease hypoxia and delay the need for oxygen therapy. [7][8][9][10][11] This hypothesis has led to the initiation of a large-scale multicenter trial in Europe utilizing hydrogen-producing tablets in high-risk patients undergoing ambulatory care.…”

“…7,8 It is hypothesized that H 2 therapy may decrease inflammation by decreasing the cytokine storm and by reducing free radical-induced damage, which may decrease hypoxia and delay the need for oxygen therapy. [7][8][9][10][11] This hypothesis has led to the initiation of a large-scale multicenter trial in Europe utilizing hydrogen-producing tablets in high-risk patients undergoing ambulatory care. 12 The concept that molecular hydrogen may be a beneficial treatment for severe COVID-19 is supported by a small trial in China that reported hydrogen inhalation was effective for reducing disease severity and dyspnea.…”