Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID‐19 patient

Singh, Ram B.; Halabi, Ghazi; Fatima, Ghizal; Richa, H.; Tarnava, Alexander T; LeBaron, Tyler W.

doi:10.1002/ccr3.5039

Cited by 15 publications

(19 citation statements)

References 32 publications

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“…Furthermore, imbibition of HRW has been demonstrated to improve O2 saturation and fatigue in a case study of post-COVID-19-like syndrome. 91 However, these results were not corroborated in a larger clinically controlled group 92 where almost doubling the concentration and duration of H2 exposure (227mL of HRW, containing 1.6mg/L (0.8mM) of H2, consumed up to five times a day for 28 days) did not produce significant data. In accordance, further in-depth research will be required if accurate dosage and treatment protocols are to be delineated.…”

Section: Molecular Hydrogen (H2) As a Treatment For Post-covid-19 Syn...mentioning

confidence: 89%

The Influence of Molecular Hydrogen Therapies in Managing the Symptoms of Acute and Chronic COVID-19

Russell

Thomas

Nenov

et al. 2022

MRAJ

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Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagious disease which can be transmitted through aerosol droplets and surface-to-host contact. Both symptomology and the severity of disease can vary wildly between individuals, from asymptomatic but infectious, to those that require critical care. Due to the neoteric emergence of SARS-CoV-2, current treatment strategies are not yet well developed and rely on the repurposing of such medications as antiviral, corticosteroid, immunosuppressant and oxygen (O2) therapies. However, the minimal efficacy of these interventions is concerning. In addition to the acute infection that prevails, it is estimated that up to 30% of adults who contract COVID-19 develop chronic symptoms lasting longer than 12 weeks. It is also estimated that 15% of children aged 2-16 years have developed long-lasting sequelae associated with SARS-CoV-2 infection. According to recent clinical data, molecular hydrogen (H2) and oxy-hydrogen (H2/O2) therapies successfully remediated the debilitating effects of SARS-CoV-2 infection in adults. By acting as an effective anti-inflammatory and antioxidative agent, it is reported that H2 administration can improve recovery through abatement of the hyperinflammatory cytokine cascade and reduction of inhalation resistance in patients with mild-moderate disease symptoms. In this review, the authors investigate the clinical and empirical evidence relating to treating the symptoms of both acute and chronic COVID-19 with H2-containing therapeutics.

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Section: Molecular Hydrogen (H2) As a Treatment For Post-covid-19 Syn...mentioning

confidence: 89%

The Influence of Molecular Hydrogen Therapies in Managing the Symptoms of Acute and Chronic COVID-19

Russell

Thomas

Nenov

et al. 2022

MRAJ

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“…and this mechanism, generates the superoxide. Molecular hydrogen has been found to be useful in protecting against free radical induced damage due to its potential antioxidant effects in various conditions [20][21][22][23][24][25][26][27][28][29].…”

Section: Free Radical Stress and Antioxidants In The Pathogenesis Of ...mentioning

confidence: 99%

“…Dietary approaches consisting of Mediterranean-style foods, yoghurt, and butter milk are used to alter the composition and improve function of the communities of the microbes that develop colonies in the gut for improvement of health, and protect against CVDs and T2DM [8,9]. In view of the known beneficial effects of hydrogen therapy [20][21][22][23][24][25][26][27][28][29], there is a need to understand how it is produced in the gut. A pilot study reported increased production of intestinal hydrogen along with recovery in muscle function following intensive exercises [30].…”

Section: Production Of Molecular Hydrogen In the Gutmentioning

confidence: 99%

Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases

Singh¹,

Fatima²,

Fedačko³

et al. 2023

Preprint

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There is evidence that behavioral risk factors such as western type diet, and life style can predispose to oxidative stress, deficiency in antioxidant status, hyperglycemia, dyslipidemia and increase in inflammation in tissues of various organs: beta cells of the pancreas, LDL receptors in the hepatocytes, endothelium, neurons, osteocytes and gut. Further studies indicate that diets rich in antioxidant flavonoids, omega-3 fatty acids and fiber in foods were inversely associated whereas western-type foods were positively associated with risk of mortality due to cardiovascular diseases (CVDs). One important cause for beneficial effects of diet may be certain foods and nutrients such as vegetables, fruits and whole grains that are rich in fiber and flavonoids, known to produce liters og molecular hydrogen in the gut. It seems that, high-fiber diets, prebiotic and probiotics can produce greater hydrogen, which acts as an antioxidant and may inhibit free radical generation. Recent studies indicate that molecular hydrogen can inhibit hydroxyl and nitrosyl radicals and can directly act as antioxidant in the cells and tissues, which can cause marked decline in oxidative stress and inflammation leading to significant decline in CVDs and metabolic diseases. Clinical and experimental studies indicate that hydrogen therapy such as hydrogen rich water can provide benefits in the management of CVDs and metabolic diseases. Larger studies are necessary to verify the role of hydrogen administration in CVDs.

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“…Numerous studies have indicated that H 2 has anti-inflammatory [ 22 ], anti-apoptosis [ 23 ], antifatigue [ 24 , 25 , 26 , 27 ], and regulatory properties [ 28 ]. Based on the reported beneficial health effects across a variety of diagnoses [ 22 , 29 ], H 2 administration has recently been proposed as a promising therapeutic gas for COVID-19 patients [ 7 , 30 , 31 , 32 , 33 , 34 , 35 ]. For instance, Guan et al [ 36 ] showed clinically beneficial effects of a hydrogen/oxygen (H 2 –O 2 ; 66–33%) mixed gas inhalation for the amelioration of most respiratory symptoms, such as dyspnea, chest distress, or cough, within days 2 and 3 of hospitalization for COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

Botek

Krejčí

Valenta

et al. 2022

IJERPH

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Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blind, placebo-controlled study included 26 males (44 ± 17 years) and 24 females (38 ± 12 years), who performed a 6-min walking test (6 MWT) and pulmonary function test, specifically forced vital capacity (FVC) and expiratory volume in the first second (FEV1). Symptomatic participants were recruited between 21 and 33 days after a positive polymerase chain reaction test. The experiment consisted of H2/placebo inhalation, 2 × 60 min/day for 14 days. Results showed that H2 therapy, compared with placebo, significantly increased 6 MWT distance by 64 ± 39 m, FVC by 0.19 ± 0.24 L, and, in FEV1, by 0.11 ± 0.28 L (all p ≤ 0.025). In conclusion, H2 inhalation had beneficial health effects in terms of improved physical and respiratory function in acute post-COVID-19 patients. Therefore, H2 inhalation may represent a safe, effective approach for accelerating early function restoration in post-COVID-19 patients.

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Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID‐19 patient

Abstract: Administration of molecular hydrogen dissolved in water to patient with COVID‐19‐like symptoms may improve oxygen levels and exercise capacity.

Cited by 15 publications

References 32 publications

The Influence of Molecular Hydrogen Therapies in Managing the Symptoms of Acute and Chronic COVID-19

The Influence of Molecular Hydrogen Therapies in Managing the Symptoms of Acute and Chronic COVID-19

Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases

Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

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