Hydrogen sulfide plays a potential alternative for the treatment of metabolic disorders of diabetic cardiomyopathy

Deng, Nian-Hua; Luo, Wen; Gui, Dan-Dan; Yan, Bin-Jie; Zhou, Kun; Tian, Kai-Jiang; Zhong, Ren; Xiong, Wenhao; Jiang, Zhi‐Sheng

doi:10.1007/s11010-021-04278-z

Cited by 5 publications

(2 citation statements)

References 107 publications

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“…Diabetes is most commonly responsible for cardiovascular disease, blindness, kidney failure, and lower limb amputations. Research has shown that hydrogen peroxide (H 2 S) can control the metabolism of cellular energy sources, reduce insulin resistance, protect cardiomyocytes, and improve cardiac function by affecting key proteins such as differentiation cluster 36 (CD36) and glucose transporter 4 (GLUT4) [ 149 ].…”

Section: Role Of Hydrogen Sulfidementioning

confidence: 99%

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

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The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.

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Section: Role Of Hydrogen Sulfidementioning

confidence: 99%

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

View full text Add to dashboard Cite

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“…These results underscored the crucial role of endogenous H 2 S in DCM progression. Evidence continues to support the effectiveness of endogenous H 2 S and exogenous H 2 S donors to prevent and treat DCM (Chen et al, 2020b;Deng et al, 2022;Qian et al, 2018;Wang, 2010;Zhou et al, 2015a). The protective effects of H 2 S in DCM likely involve multiple cellular and molecular mechanisms.…”

Section: H 2 S In Diabetic Complicationsmentioning

confidence: 99%