The role of adipose tissue-derived hydrogen sulfide in inhibiting atherosclerosis

Tian, Zhen; Deng, Nian-Hua; Zhou, Zikang; Zhong, Ren; Xiong, Wenhao; Jiang, Zhisheng

doi:10.1016/j.niox.2022.07.001

Cited by 4 publications

(2 citation statements)

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“…In fact, medium-chain saturated fats in red meat are more likely to increase serum HDL cholesterol (16,17). Excessive consumption of long-chain fatty acids in red meat can induce endoplasmic reticulum (ER) stress, and oxidative stress is upstream of vascular inflammation and relative dysfunction (16,(61)(62)(63)(64).…”

Section: Discussionmentioning

confidence: 99%

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Sun

Yuan

Chen

et al. 2022

Front. Cardiovasc. Med.

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AimThe study (PROSPERO: CRD42021240905) aims to reveal the relationships among red meat, serum lipids and inflammatory biomarkers.Methods and resultsPubMed, EMBASE and the Cochrane databases were explored through December 2021 to identify 574 studies about red meat and serum lipids markers including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP) or hypersensitive-CRP (hs-CRP). Finally, 20 randomized controlled trials (RCTs) involving 1001 people were included, red meat and serum lipid markers and their relevant information was extracted. The pooled standard mean difference (SMD) was obtained by applying a random-effects model, and subgroup analyses and meta-regression were employed to explain the heterogeneity. Compared with white meat or grain diets, the gross results showed that the consumption of red meat increased serum lipid concentrations like TG (0.29 mmol/L, 95% CI 0.14, 0.44,P<0.001), but did not significantly influence the TC (0.13 mmol/L, 95% CI −0.07, 0.33, P = 0.21), LDL-C (0.11 mmol/L, 95% CI −0.23, 0.45, P = 0.53), HDL-C (−0.07 mmol/L, 95% CI −0.31, 0.17, P = 0.57),CRP or hs-CRP (0.13 mmol/L, 95% CI −0.10, 0.37,P = 0.273).ConclusionOur study provided evidence to the fact that red meat consumption affected serum lipids levels like TG, but almost had no effect on TC, LDL-C, HDL-C and CRP or hs-CRP. Such diets with red meat should be taken seriously to avoid the problem of high lipid profiles.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO], identifier [CRD42021240905].

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Section: Discussionmentioning

confidence: 99%

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Sun

Yuan

Chen

et al. 2022

Front. Cardiovasc. Med.

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“…Investigating the mechanisms underlying the protective effects of H 2 S on adipose tissue inflammation and atherosclerosis development, including the regulation of oxidative stress, autophagy, and immune responses, and whether H 2 S is involved in the browning of white adipocytes is also a critical topic regarding H 2 S as a double-edged sword in vivo; a high dose has a toxic effect, while a low dose has a therapeutic effect. Defining the therapeutic window is fundamental for developing H 2 S medicinal drugs [78,79].…”

Section: Results Seen As Progress In the Last 5 Years (2018-2023) Res...mentioning

confidence: 99%

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

Munteanu

2023

IJMS

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Atherosclerosis is a complex pathological condition marked by the accumulation of lipids in the arterial wall, leading to the development of plaques that can eventually rupture and cause thrombotic events. In recent years, hydrogen sulfide (H2S) has emerged as a key mediator of cardiovascular homeostasis, with potential therapeutic applications in atherosclerosis. This systematic review highlights the importance of understanding the complex interplay between H2S, oxygen homeostasis, and atherosclerosis and suggests that targeting H2S signaling pathways may offer new avenues for treating and preventing this condition. Oxygen homeostasis is a critical aspect of cardiovascular health, and disruption of this balance can contribute to the development and progression of atherosclerosis. Recent studies have demonstrated that H2S plays an important role in maintaining oxygen homeostasis by regulating the function of oxygen-sensing enzymes and transcription factors in vascular cells. H2S has been shown to modulate endothelial nitric oxide synthase (eNOS) activity, which plays a key role in regulating vascular tone and oxygen delivery to tissues. The comprehensive analysis of the current understanding of H2S in atherosclerosis can pave the way for future research and the development of new therapeutic strategies for this debilitating condition. PROSPERO ID: 417150.

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Hydrogen sulfide donors across time: From origins to cutting-edge applications

Zhao,

Wang,

et al. 2024

Nitric Oxide

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The role of adipose tissue-derived hydrogen sulfide in inhibiting atherosclerosis

Cited by 4 publications

References 100 publications

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

Hydrogen sulfide donors across time: From origins to cutting-edge applications

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