Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

Li, Panpan; Liu, Hanhan; Shi, Xin; Prokosch, Verena

doi:10.3390/molecules26092411

Cited by 19 publications

(15 citation statements)

References 159 publications

(207 reference statements)

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“…Besides, the sustained accumulation of ROS without timely clearance induces the occurrence of oxidative stress, which is intimately associated with many etiological/pathological conditions, such as neurodegenerative disorders, cardiovascular diseases, cancer, diabetes, and aging 266–268 . Hopefully, it is firmly established that H 2 S has preventive/therapeutical effects on oxidative stress‐mediated diseases through various mechanisms 71,269–274 . In this sense, the development of ROS‐triggered H 2 S donors would supply a new diagnostic approach or therapeutical strategy for many diseases.…”

Section: H2s Donors and H2s‐releasing Hybrid Moleculesmentioning

confidence: 99%

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song

Zhao

et al. 2022

Medicinal Research Reviews

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Section: H2s Donors and H2s‐releasing Hybrid Moleculesmentioning

confidence: 99%

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song

Zhao

et al. 2022

Medicinal Research Reviews

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“…H 2 S is known to produce nitroxyl, a one-electron reduction of NO. It can also help restore the relaxation caused by the depletion of NO [ 101 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Munteanu

Rotariu

Turnea

et al. 2022

IJMS

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Abundant experimental data suggest that hydrogen sulfide (H2S) is related to the pathophysiology of Diabetes Mellitus (DM). Multiple molecular mechanisms, including receptors, membrane ion channels, signalingmolecules, enzymes, and transcription factors, are known to be responsible for the H2S biological actions; however, H2S is not fully documented as a gaseous signaling molecule interfering with DM and vascular-linked pathology. In recent decades, multiple approaches regarding therapeutic exploitation of H2S have been identified, either based on H2S exogenous apport or on its modulated endogenous biosynthesis. This paper aims to synthesize and systematize, as comprehensively as possible, the recent literature-related data regarding the therapeutic/rehabilitative role of H2S in DM. This review was conducted following the “Preferred reporting items for systematic reviews and meta-analyses” (PRISMA) methodology, interrogating five international medically renowned databases by specific keyword combinations/“syntaxes” used contextually, over the last five years (2017–2021). The respective search/filtered and selection methodology we applied has identified, in the first step, 212 articles. After deploying the next specific quest steps, 51 unique published papers qualified for minute analysis resulted. To these bibliographic resources obtained through the PRISMA methodology, in order to have the best available information coverage, we added 86 papers that were freely found by a direct internet search. Finally, we selected for a connected meta-analysis eight relevant reports that included 1237 human subjects elicited from clinical trial registration platforms. Numerous H2S releasing/stimulating compounds have been produced, some being used in experimental models. However, very few of them were further advanced in clinical studies, indicating that the development of H2S as a therapeutic agent is still at the beginning.

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“… In mammals, H 2 S is produced via several pathways. Cystathionine- β -synthase (CBS) and cystathionine- γ -lyase (CSE) interact with cysteine to produce H 2 S following the reverse transsulfuration pathway and α , β -elimination, respectively [ 39 , 40 ]. The production of H 2 S also involves enzymes such as methionine- γ -lyase and cysteine desulfhydrase [ 24 ].…”

Section: Figurementioning

confidence: 99%

A Whiff of Sulfur: One Wind a Day Keeps the Doctor Away

et al. 2022

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Reactive Sulfur Species (RSS), such as allicin from garlic or sulforaphane from broccoli, are fre-quently associated with biological activities and possible health benefits in animals and humans. Among these Organic Sulfur Compounds (OSCs) found in many plants and fungi, the Volatile Sulfur Compounds (VSCs) feature prominently, not only because of their often-pungent smell, but also because they are able to access places which solids and solutions cannot reach that easily. Indeed, inorganic RSS such as hydrogen sulfide (H2S) and sulfur dioxide (SO2) can be used to lit-erally fumigate entire rooms and areas. Similarly, metabolites of garlic, such as allyl methyl sulfide (AMS), are formed metabolically in humans in lower concentrations and reach the airways from inside the body as part of one’s breath. Curiously, H2S is also formed in the gastrointestinal tract by gut bacteria, and the question of if and for which purpose this gas then crosses the barriers and enters the body is indeed a delicate matter for equally delicate studies. In any case, nature is surprisingly rich in such VSCs, as fruits (for instance, the infamous durian) demonstrate, and therefore these VSCs represent a promising group of compounds for further studies.

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Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

Cited by 19 publications

References 159 publications

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

A Whiff of Sulfur: One Wind a Day Keeps the Doctor Away

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