Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous

Sokolov, Alexander S.; Nekrasov, Pavel V.; Shaposhnikov, Mikhail; Moskalev, Alexey

doi:10.1016/j.arr.2021.101262

Cited by 27 publications

(18 citation statements)

References 450 publications

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“…Herein, taken hydrogen sulfide (H 2 S) [ 29–32 ] gas detection as a case, a common and frequently lethal gas, which exists widely in the petrochemical industry, urban sewage pipeline, and organic chemical raw materials. We investigated systematically the effect of In 2 O 3 supported Pd SACs (defined as In 2 O 3 /Pd atom ) on H 2 S gas sensing behavior by combing performances testing, density functional theory (DFT) calculations with quasi in situ X‐ray photoelectron spectroscopy (XPS) analysis.…”

Section: Introductionmentioning

confidence: 99%

The Dehydrogenation of H‐S Bond into Sulfur Species on Supported Pd Single Atoms Allows Highly Selective and Sensitive Hydrogen Sulfide Detection

Liu

Zhang

Luo

et al. 2021

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The supported metal catalysts on scaffolds usually reveal multiple active sites, resulting in the occurrence of side reaction and being detrimental to the achievement of highly consistent catalysis. Single atom catalysts (SACs), possessed with highly consistent single active sites, have great potentials for overcoming such issues. Herein, the authors used SACs to modulate kinetic process of gas sensitive reaction. The supported Pd SACs, established by a metal organic frameworks‐templated approach, promoted greatly the detection capacity to hydrogen sulfide (H2S) gas with a very high sensitivity and selectivity. Density functional theory calculations show that the supported Pd SACs not only increased the number of electrons transferring from H2S molecules to Pd SACs, but strengthened surface affinity to H2S. Moreover, the HS bonds of H2S molecules absorbed on Pd atomic sites are more likely to be dehydrogenated directly into sulfur species. Significantly, quasi in situ XPS analysis confirmed the presence of sulfur species during H2S detection process, which may be a major cause for such detection signal. Based on these results, a suitable sensing principle for H2S gas driven by Pd SACs was put forward. This work will enrich catalytic electronics in chemiresistive gas sensing.

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Section: Introductionmentioning

confidence: 99%

The Dehydrogenation of H‐S Bond into Sulfur Species on Supported Pd Single Atoms Allows Highly Selective and Sensitive Hydrogen Sulfide Detection

Liu

Zhang

Luo

et al. 2021

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“…Provided its intake remains sufficient, the less methionine is consumed, the more its metabolization is directed toward the production of glutathione and the gas hydrogen sulfide. Glutathione is an antioxidant and in small quantities so is hydrogen sulfide, but hydrogen sulfide is particularly important as a kind of neurotransmitter ( Paul and Snyder, 2018 ; Kitada et al, 2021 ; Paul, 2021 ; Sokolov et al, 2021 ). The less methionine or SAM and the more hydrogen sulfide is available to a cell, the more of the cell’s dysfunctional mitochondria and other debris are recycled, the better its remaining mitochondria and cellular components perform, and the fewer free radicals its mitochondria release ( Paul and Snyder, 2018 ; Wu et al, 2020 ; Kitada et al, 2021 ; Sokolov et al, 2021 ).…”

Section: The Microbiota’s Hydrogen Sulfide Can Either Benefit or Harm Mitochondriamentioning

confidence: 99%

“…Glutathione is an antioxidant and in small quantities so is hydrogen sulfide, but hydrogen sulfide is particularly important as a kind of neurotransmitter ( Paul and Snyder, 2018 ; Kitada et al, 2021 ; Paul, 2021 ; Sokolov et al, 2021 ). The less methionine or SAM and the more hydrogen sulfide is available to a cell, the more of the cell’s dysfunctional mitochondria and other debris are recycled, the better its remaining mitochondria and cellular components perform, and the fewer free radicals its mitochondria release ( Paul and Snyder, 2018 ; Wu et al, 2020 ; Kitada et al, 2021 ; Sokolov et al, 2021 ). This, in turn, allows fatty-acid producing gut bacteria to thrive at the expense of gut pathogens ( Wu et al, 2020 ) and promotes a normal permeability of the gut-blood barrier ( Ramalingam et al, 2010 ).…”

Section: The Microbiota’s Hydrogen Sulfide Can Either Benefit or Harm Mitochondriamentioning

confidence: 99%

Mitochondria-Microbiota Interaction in Neurodegeneration

Krämer

2021

Front. Aging Neurosci.

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Alzheimer’s and Parkinson’s are the two best-known neurodegenerative diseases. Each is associated with the excessive aggregation in the brain and elsewhere of its own characteristic amyloid proteins. Yet the two afflictions have much in common and often the same amyloids play a role in both. These amyloids need not be toxic and can help regulate bile secretion, synaptic plasticity, and immune defense. Moreover, when they do form toxic aggregates, amyloids typically harm not just patients but their pathogens too. A major port of entry for pathogens is the gut. Keeping the gut’s microbe community (microbiota) healthy and under control requires that our cells’ main energy producers (mitochondria) support the gut-blood barrier and immune system. As we age, these mitochondria eventually succumb to the corrosive byproducts they themselves release, our defenses break down, pathogens or their toxins break through, and the side effects of inflammation and amyloid aggregation become problematic. Although it gets most of the attention, local amyloid aggregation in the brain merely points to a bigger problem: the systemic breakdown of the entire human superorganism, exemplified by an interaction turning bad between mitochondria and microbiota.

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“… 2017 ; Sokolov et al . 2021 ). At physiological solutions, approximately 80% of H 2 S exists in dissociated form, so hydrosulfide anion (HS − ), 20% of H 2 S and vanishingly little S 2− (Olson 2012 ; Sokolov et al .…”

Section: Sulfur Metabolism In S Pombementioning

confidence: 99%

“…At physiological solutions, approximately 80% of H 2 S exists in dissociated form, so hydrosulfide anion (HS − ), 20% of H 2 S and vanishingly little S 2− (Olson 2012 ; Sokolov et al . 2021 ). In S. pombe , H 2 S and sulfide are thought to have three possible fates.…”

Section: Sulfur Metabolism In S Pombementioning

confidence: 99%

Response to sulfur in Schizosaccharomyces pombe

Ohtsuka

Shimasaki

Aiba

2021

FEMS Yeast Research

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Sulfur is an essential component of various biologically important molecules, including methionine, cysteine, and glutathione, and it is also involved in coping with oxidative and heavy metal stress. Studies using model organisms, including budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe), have contributed not only to understanding various cellular processes but also to understanding the utilization and response mechanisms of each nutrient, including sulfur. Although fission yeast can use sulfate as a sulfur source, its sulfur metabolism pathway is slightly different from that of budding yeast because it does not have a trans-sulfuration pathway. In recent years, it has been found that sulfur starvation causes various cellular responses in S. pombe, including sporulation, cell cycle arrest at G2, chronological lifespan extension, autophagy induction, and reduced translation. This MiniReview identifies two sulfate transporters in S. pombe, Sul1 (encoded by SPBC3H7.02) and Sul2 (encoded by SPAC869.05c), and summarizes the metabolic pathways of sulfur assimilation and cellular response to sulfur starvation. Understanding these responses, including metabolism and adaptation, will contribute to a better understanding of the various stress and nutrient starvation responses and chronological lifespan regulation caused by sulfur starvation.

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Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous

Cited by 27 publications

References 450 publications

The Dehydrogenation of H‐S Bond into Sulfur Species on Supported Pd Single Atoms Allows Highly Selective and Sensitive Hydrogen Sulfide Detection

The Dehydrogenation of H‐S Bond into Sulfur Species on Supported Pd Single Atoms Allows Highly Selective and Sensitive Hydrogen Sulfide Detection

Mitochondria-Microbiota Interaction in Neurodegeneration

Response to sulfur in Schizosaccharomyces pombe

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