Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction

Wang, Jing; Wang, Wan; Li, Shuangyue; Han, Yi; Zhang, Ping; Meng, Guoliang; Xiao, Yuchen; Xie, Liping; Wang, Xin; Sha, Jiahao; Chen, Qi; Moore, Philip K.; Wang, Rui; Xiang, Wenpei; Ji, Yong

doi:10.1089/ars.2016.6968

Cited by 41 publications

(61 citation statements)

References 45 publications

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“…Nowadays, H 2 S has been generally recognized as a novel “gasotransmitter” with similar properties of nitric oxide and carbon monoxide. Moreover, previous study has verified the powerful ability of antioxidation by H 2 S in several systems …”

Section: Introductionmentioning

confidence: 79%

“…H 2 S has potential ability of antioxidative stress in different tissues. The latest study found that H 2 S suppressed oxidative stress to inhibit NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in macrophages, to attenuate myocardial hypertrophy and fibrosis, to alleviate spermatogenic failure and testicular dysfunction and to suppress aortic atherosclerotic plaque formation . Importantly, H 2 S also exhibited antioxidative effect on skin.…”

Section: Discussionmentioning

confidence: 99%

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Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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Hydrogen sulphide (H2S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H2S on skin wound healing are not known well. In the present study, 129S1/SvImJ mice were intraperitoneally injected with NaHS (50 μmol/kg/d) for 2 weeks. Then, a round wound of 6 mm diameter with depth into the dermis was made. The skin wound area, blood perfusion, superoxide production, malondialdehyde (MDA) levels, total antioxidant capacity (T‐AOC), expression of vascular endothelial growth factor (VEGF), dynamin‐related protein 1 (DRP1) and optic atrophy 1 (OPA1) were measured. After NaHS (50 μmol/L) pre‐administration for 4 hours, cell migration rate, DRP1, OPA1 and α–smooth muscle actin (α‐SMA) expression, superoxide production and mitochondrial membrane potential in primary skin fibroblasts were measured. Tube formation in human umbilical vein endothelial cells (HUVECs) and cell migration in human keratinocytes were also measured. The results showed that NaHS pretreatment significantly accelerated wound healing and improved blood flow in the wound after operation. NaHS increased VEGF expression in the wound and promoted tube formation in HUVECs. Meanwhile, NaHS attenuated reactive oxygen species (ROS) production, suppressed MDA level but restored T‐AOC in the wound. NaHS also promoted skin fibroblasts migration and α‐SMA expression after scratch. Moreover, NaHS alleviated ROS, increased mitochondrial membrane potential, decreased DRP1 but enhanced OPA1 expression in skin fibroblasts after scratch. NaHS also accelerated human keratinocytes migration after scratch. Taken together, exogenous H2S supplementary accelerated the skin wound healing, which might be related to oxidative stress inhibition and VEGF enhancement.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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“…It was reported that CSE is expressed in sertoli cells, spermatogonia and epididymis of rats. For instance, the therapeutic effects of H 2 S are reported in erectile dysfunction, heat-induced injury in testicular germ cells and diabetes-induced testicular dysfunction (Li, Xie, Chua, Wong, & Bian, 2015;Wang et al, 2018;Zhu et al, 2011). D,L-propargylglycine (PAG) is a well-known CSE enzyme inhibitor, which is used in this study to explore the exact role of CSE in this model of rat varicocele.…”

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confidence: 99%

Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

et al. 2019

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The main aim of this study was to assay the testicular H2S levels in the varicocele rat model and then to investigate the protective effects of NaHS on morphometric changes, sperm parameters, oxidative stress and apoptosis markers in rat's testis. D,L‐propargylglycine (PAG) was administrated to show the effects of cystathionine γ‐lyase enzyme (CSE) inhibition in the varicocele. Rats were assigned to four groups: (a) Sham, (b) varicocele, (c) varicocele + PAG and (d) varicocele + NaHS. Animals in varicocele + NaHS group received 30 µmol/L NaHS in drinking water for 56 days. In the varicocele + PAG group, animals received PAG 19 mg/kg twice a week. Morphometric assessment, oxidative stress markers, testicular H2S levels, sperm parameters, TUNEL assay and expression of Bax/Bcl2 were evaluated at the end of experiment. Testicular H2S levels were significantly decreased in varicocele group. NaHS significantly improved sperm parameters, morphometric characteristics and oxidative stress compared to varicocele group. Oxidative stress status deteriorated in the PAG group compared to the varicocele group. This study showed that a low testicular H2S level might play a critical role in male infertility. Thus, NaHS administration may be a promising treatment strategy for male infertility in varicocele. In addition, CSE may not be the only important enzyme in testicular H2S production.

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“…Importance of H 2 S on normal testes function, for example spermatogenesis, has been shown by the very recent data of Wang and co‐workers who reported that stress induced reductions of endogenous H 2 S production and CBS expression in testes, is followed by impaired spermatogenesis and a defective blood testicular barrier. They further showed that the exogenous administration of H 2 S can exert protective effects in lipopolysaharide induced testicular pathologies, and could relieve the spermatogenic failure.…”

Section: Physiological Signaling Of Rss In Male Reproductive Eventsmentioning

confidence: 95%

“…Namely, reactive oxygen and nitrogen species (ROS and RNS, respectively) have appeared as key players in crucial sperm reproductive functions. In addition, during the last decade, reactive sulfur species (RSS), firstly hydrogen sulfide (H 2 S) was identified and characterized as novel important redox signaling molecule in male reproductive system …”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology

et al. 2019

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Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling.

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Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction

Abstract: HS plays an important role in spermatogenic failure and testicular dysfunction mainly by its anti-inflammatory and antioxidative effects. Antioxid. Redox Signal. 28, 1447-1462.

Cited by 41 publications

References 45 publications

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Long‐term NaHS administration reduces oxidative stress and apoptosis in a rat model of left‐side varicocele

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology

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