Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats

Sun, Qiang; Kang, Zhiwei; Jian-Hua, Cai; Liu, Wenwu; Zhang, Junyi; Denoble, Petar J.; Tao, Hengyi; Sun, Xuejun

doi:10.3181/0812-rm-349

Cited by 147 publications

(137 citation statements)

References 34 publications

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“…Sun et al, 23 Nakao et al, 24 Chen et al 31 Caspase-12 Neonatal hypoxia, spinal cord injury Cai et al, 43 Chen et al 31 , increase of the marker; , decrease of the marker; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; MDA, malondialdehyde; I/R, ischaemia-reperfusion; 4HNE, 4-hydroxynonenal; 8-OHdG, 8-hydroxydeoxyguanosine; MPO, myeloperoxidase; 8-oxoG, 8-oxoguanine; 8-isoPGF 2α , 8-isoprostane; DAO, diamine oxidase; TBARs, thiobarbituric acid reactive substances; NADPH, reduced nicotinamide adenine dinucleotide phosphate; IL, interleukin; TNF-α, tumour necrosis factor α; HMGB1, high-mobility group box 1; PCNA, proliferating cell nuclear antigen; IFN-γ, interferon-γ; CCL2, chemokine (C-C motif) ligand 2; ICAM-1, intercellular adhesion molecule-1; iNOS, inducible nitric oxide synthase; Iba1, ionized calcium binding adaptor molecule 1; Lyn-P, phosphorylated Lyn tyrosine kinase; MAPK, mitogen-activated protein kinase; MEK-1, MAP-extracellular signal regulated protein kinase-1; NF-κβ, nuclear factor-κβ; TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labelling. These results argue that H 2 has significant antioxidant effects in I/R injury.…”

Section: I/r Injury Spinal Cord Injurymentioning

confidence: 99%

“…14 Oxidative MDA I/R (hepatic, intestinal, neonatal Fukuda et al, 18 Zheng et stress hypoxia, cardiac, renal), Alzheimer's al., 19 Mao et al, 20 Cai et disease, cognitive disorders, al., 21 Chen et al, 22 Sun pancreatitis, atherosclerosis, et al, 23 Nakao et al, 24 obstructive jaundice, radiation and…”

Section: Radiation Complication Qian Et Almentioning

confidence: 99%

“…Atherosclerosis, Parkinson's disease, Ohsawa et al, 29 Fu et Alzheimer's disease, cognitive al., 32 Fujita et al, 33 Li et disorders, I/R (renal and retinal), al., 26 Nagata et al, 27 haemorrhagic Cardinal et al, 25 Oharazawa et al, 34 Chen et al 35 8-OHdG I/R (cerebral, myocardium, retinal, Ohsawa et al, 13 Hayashida renal), Parkinson's disease, et al, 36 Sun et al, 23 haemorrhagic, metabolic syndrome, Oharazawa et al, 34 …”

Section: Hnementioning

confidence: 99%

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Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

2010

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Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H 2 ) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H 2 (inhaled or orally ingested, typically as approximately 0.8 mM H 2 -saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H 2 -saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H 2 has selective antioxidant properties, and can exert antiapoptotic, antiinflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H 2 .

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Section: I/r Injury Spinal Cord Injurymentioning

confidence: 99%

Section: Radiation Complication Qian Et Almentioning

confidence: 99%

Section: Hnementioning

confidence: 99%

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Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

2010

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“…It has been demonstrated that H 2 exerted preventive or therapeutic effects on cerebral, myocardial and hepatic ischemia-reperfusion injuries, intestinal, lung, renal and heart transplantation, and acute graft-versus-host disease post-allogeneic hematopoietic stem cell transplantation (20,21). Recent basic and clinical research revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs (22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Qing-xi

Pan

et al. 2017

Molecular and Clinical Oncology

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Abstract. The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups. At the end of the study, 76 patients in the hydrogen treatment group and 60 patients in the placebo group were included in the final analysis. The changes in liver function after the chemotherapy, such as altered levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase, indirect bilirubin (IBIL) and direct bilirubin, were observed. The damaging effects of the mFOLFOX6 chemotherapy on liver function were mainly represented by increased ALT, AST and IBIL levels. The hydrogen-rich water group exhibited no significant differences in liver function before and after treatment, whereas the placebo group exhibited significantly elevated levels of ALT, AST and IBIL. Thus, hydrogen-rich water appeared to alleviate the mFOLFOX6-related liver injury.

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“…Different from hydrogen gas, hydrogen-rich saline is safe, economical and easily available, which is also proved to be cardioprotective through the anti-oxidative stress and apoptotic pathways [17].…”

Section: Introductionmentioning

confidence: 99%

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

Zhang

et al. 2013

J Assist Reprod Genet

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Purpose The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice. Methods The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive system and testicular oxidative levels in nicotinetreated (4.5 mg/kg, s.b.) mice were investigated. Results It was found that vitamin C and vitamin E attenuated serum oxidative level, but did not lower testicular oxidative levels in mice subjected to chronic nicotine treatment, and did not improve the male reproductive damage and apoptosis induced by nicotine. Different from normal antioxidants, vitamin C and vitamin E, hydrogen-rich saline abated oxidative stress in testis, and protected against nicotine-induced male reproductive damages. Conclusion Our results first demonstrated that long-term treatment with hydrogen-rich saline attenuated testicular oxidative level and improved male reproductive function in nicotine-treated mice.

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Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats

Cited by 147 publications

References 34 publications

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

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