Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

Wang, Fei; Yu, Guang; Liu, Sui-yi; Li, Jinbao; Wang, Jiafeng; Bo, Lulong; Qian, Liren; Sun, Xuejun; Deng, Xiaoming

doi:10.1016/j.jss.2010.11.005

Cited by 95 publications

(69 citation statements)

References 21 publications

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“…The year survival rate of transplant kidney has increased from 45 to 90% (19). Chronic organ damage induced by RIRI has attracted increasing attention (20). The present results indicate that tanshinone IIA pretreatment normalizes markers of renal function, and reduced BUN and creatinine levels in the I/RIRI-induced rats.…”

Section: Discussionmentioning

confidence: 49%

“…In recent years, it has been detected through investigation that MIF plays a central role in inflammatory reactions, including activation in T lymphocytes (20). MIF is generated by a variety of tissues and cells, including pituitary gland tissues, monocyte/macrophages and T lymphocytes (18).…”

Section: Discussionmentioning

confidence: 99%

“…MIF is generated by a variety of tissues and cells, including pituitary gland tissues, monocyte/macrophages and T lymphocytes (18). MIF is a proinflammatory mediator and a hormone derived from hypophysis (20). It can be used as a negative feedback regulator of glucocorticoid physiological activities.…”

Section: Discussionmentioning

confidence: 99%

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Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Ding

Huang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti-inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF-α and IL-6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase-3, B-cell lymphoma 2 (Bcl-2) and p38 mitogen-activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinone IIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF-α and IL-6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase-3 and p38 MAPK protein expression levels in I/RIRI rats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase-3 and p38 MAPK.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Ding

Huang

et al. 2016

Experimental and Therapeutic Medicine

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“…Accumulating evidence suggests that hydrogen has medicinal properties (4)(5)(6)(7)(8)(9)(10)(11)19); however, the molecular mechanism has yet to be elucidated. Little is known about the potential role of hydrogen in femoral head necrosis.…”

Section: A B a B Discussionmentioning

confidence: 99%

“…A number of studies have reported promising results regarding the role of hydrogen in treating diseases in the brain (4,5), heart (6), liver (7), kidney (8), intestine (9), lung (10) and spinal cord (11). Hydrogen has a positive effect in inhibiting oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model

Huang

Jiao

Yan

2015

Experimental and Therapeutic Medicine

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Abstract.A growing body of evidence suggests that hydrogen is a novel, selective antioxidant that exerts a protective effect against organ damage. The present study investigated the effect of hydrogen-rich saline on corticosteroid-induced necrosis of the femoral head in an animal model established using prednisolone. A total of 30 healthy, male, adult New Zealand white rabbits were randomly divided into two groups: Hydrogen-rich saline (treated with hydrogen-rich saline via intraperitoneal injection) and placebo (treated with normal saline). At the set time-points, the structure of the femoral head was examined using a microscope; the concentrations of glutathione (GSH), lipid peroxide (LPO), vascular endothelial growth factor (VEGF) and thrombomodulin (TM) in the plasma were measured and the microvessel density was quantified. The results showed that hydrogen-rich saline significantly decreased the levels of VEGF, TM and LPO and increased the GSH level in steroid-associated necrosis of the femoral head in the rabbit model. A significant increase in the microvessel density was observed in the hydrogen-rich saline group. Histopathological staining confirmed the results of the biochemical analysis. The present study demonstrates that hydrogen treatment may alleviate steroid-associated osteonecrosis by inhibiting oxidative stress. Hydrogen-rich saline may provide an alternative treatment for steroid-associated necrosis of the femoral head.

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H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs

Yoshida

Asanuma

Sasaki

et al. 2012

Cardiovasc Drugs Ther

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Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

Cited by 95 publications

References 21 publications

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model

H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs

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