Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Abstract

Abstract. Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti-inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF-α and IL-6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase-3, B-cell lymphoma 2 (Bcl-2) and p38 mitogen-activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinone IIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF-α and IL-6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase-3 and p38 MAPK protein expression levels in I/RIRI rats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase-3 and p38 MAPK.

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

“…A recent study reported that Tanshinone IIA could up-regulate the expression of Bcl-2, an anti-apoptotic protein [10]. On another hand, it was also reported Nrf2 activation contributed to Tanshinone IIA induced neuroprotection by inducing transcription of large numbers of antioxidant genes including heme oxygenase-1 (HO-1) [15].…”

“…Tanshinone IIA is an active monomer extracted from S. miltiorrhiza [8], which plays a key role in the plant’s clinical efficacy. Previous studies suggest that Tanshinone IIA is neuroprotective in cerebral ischemia reperfusion injury [8, 9] and renoprotective in renal ischemia reperfusion injury [10]. .…”

Tanshinone IIA Combined With CsA Inhibit Myocardial Cell Apoptosis Induced by Renal Ischemia-reperfusion Injury by Modulating Mitochondrial Function Through PI3K/Akt/Bad Pathway in Obese Rats 

“…According to previous studies, some anti-in ammatory agents have been discovered, including αmelanocyte stimulating hormone, anti-apoptotic agents, and IL-6 inhibitors [38,39]. A previous study reported that renal IR induces dysfunction in lung mitochondria and dexmedetomidine attenuates lung in ammation, apoptosis, and the MMP [38].…”

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

“…Furthermore, intensive research has discovered the renoprotective effect of STS, which has drawn much significant attention and is becoming a research hot spot. Recent publications have demonstrated that tanshinone IIA can exert its renoprotective effects by fighting oxidative stress, attenuating renal fibrosis, regulating inflammation, counteracting ischemia-reperfusion injury, protecting podocytes and endothelial cells, and ameliorating microcirculatory disturbance (Han et al, 2008;Wang et al, 2015;Xu et al, 2016;Cao et al, 2017;Zhu et al, 2017). Increasing evidence indicates that STS combined with antihypertensive drugs like ARBs can additively alleviate the renal dysfunction induced by hypertension.…”