Hydrogen-Peroxide Synthesis and LDL-Uptake Controls Immunosuppressive Properties in Monocyte-Derived Dendritic Cells

Menzner, Ann-Katrin; Rottmar, Tanja; Voelkl, Simon; Bosch, Johanna L.; Mougiakakos, Dimitrios; Mackensen, Andréas; Resheq, Yazid J.

doi:10.3390/cancers13030461

Cited by 6 publications

(3 citation statements)

References 58 publications

(36 reference statements)

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“…These changes are significant, implying that all the treatments elicit a negative effect on neutrophil level. Monocytes play crucial roles in innate and adaptive immunity during inflammation [48][49][50]. The results of the present study revealed a low count of monocyte cells, which could result from immunosuppression and bone marrow failure and/or damage [51][52].…”

Section: Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copymentioning

confidence: 56%

Effects of Biopolymers from Cassava Implanted with Rodent Bait on Wistar Rats

Okareh¹,

JC-UkA²,

Oyagbemi³

et al. 2021

Pol. J. Environ. Stud.

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The increase in the use of plastic-based materials has resulted in the generation of large volumes of plastic wastes that are non-biodegradable, and this is of public health concern. Hence, there is a need to adopt an eco-friendly technology that is capable of producing plastics that are biodegradable, and less hazardous to man and the environment. The study focuses on the conversion of biopolymer to bioplastic rodent bait and its toxicological effects. The toxicological effect of the product was tested on forty-five male Wistar rats randomly distributed into 9 groups after acclimatization period of two weeks. The groups include: Group 1 (Bioplastic alone); Group 2 (Bait meal + 1.5 g zinc phosphide); Group 3 (Bait meal + 3 g zinc phosphide), and Group 4 (Bait meal + 6 g zinc phosphide). Rats were fed ad libitum for 5 days in which their body weights, morphological changes, and time of death were recorded daily. After exposure experimental to diets, histopathological, biochemical, and haematological parameters were determined. Morphological observations such as reduced activities, fur loss in toxicant fed rats in comparison to the control were observed. The results showed that serum Aspartate Transaminase (AST) and Alanine Transferase (ALT) activities were highest in test groups compared to the control. The histopathological analysis revealed high levels of inflammatory cells, necrosis and haemorrhage within the test groups when compared with the control. Bioplastics produced from cassava residues as rodent bait were highly effective. These bioplastics can be used for the control of household rodents. Therefore, this technology can be adopted for domestic eradication of rodents.

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Section: Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copymentioning

confidence: 56%

Effects of Biopolymers from Cassava Implanted with Rodent Bait on Wistar Rats

Okareh¹,

JC-UkA²,

Oyagbemi³

et al. 2021

Pol. J. Environ. Stud.

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“…Apart from LDs, lipoprotein metabolism also impacts DC function. Immature moDCs were shown to display notably increased NADPH-oxidase-driven H 2 O 2 -production and LDL uptake ( 81 ). These features contributed to the immunosuppressive function of immature moDCs, whereas blocking LDL uptake restored their maturation capacity and attenuated their immunosuppressive properties.…”

Section: Lipid Metabolism Reprogramming Of Various Immunocytes In The...mentioning

confidence: 99%

Targeting lipid metabolism reprogramming of immunocytes in response to the tumor microenvironment stressor: A potential approach for tumor therapy

et al. 2022

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The tumor microenvironment (TME) has become a major research focus in recent years. The TME differs from the normal extracellular environment in parameters such as nutrient supply, pH value, oxygen content, and metabolite abundance. Such changes may promote the initiation, growth, invasion, and metastasis of tumor cells, in addition to causing the malfunction of tumor-infiltrating immunocytes. As the neoplasm develops and nutrients become scarce, tumor cells transform their metabolic patterns by reprogramming glucose, lipid, and amino acid metabolism in response to various environmental stressors. Research on carcinoma metabolism reprogramming suggests that like tumor cells, immunocytes also switch their metabolic pathways, named “immunometabolism”, a phenomenon that has drawn increasing attention in the academic community. In this review, we focus on the recent progress in the study of lipid metabolism reprogramming in immunocytes within the TME and highlight the potential target molecules, pathways, and genes implicated. In addition, we discuss hypoxia, one of the vital altered components of the TME that partially contribute to the initiation of abnormal lipid metabolism in immune cells. Finally, we present the current immunotherapies that orchestrate a potent antitumor immune response by mediating the lipid metabolism of immunocytes, highlight the lipid metabolism reprogramming capacity of various immunocytes in the TME, and propose promising new strategies for use in cancer therapy.

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“…Six of the papers focus on the role of specific cell types in tumor immune evasion. Among these, the research paper by Menzner et al [ 9 ] reported a novel axis between hydrogen peroxide and low-density lipoproteins-mediated axis in immunosuppressive abilities of monocyte-derived dendritic cells. The review by Demkow [ 10 ] underlined the multifaceted crosstalk between cancer and neutrophil extracellular traps during tumor progression.…”

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confidence: 99%