Hydrogen peroxide production stimulated by N-formyl-methionyl-leucyl-phenylalanine in guinea pig macrophages and effects of anti-inflammatory drugs and local anesthetics.

Moriguchi, Keiichi; Hirai, Kei-Ichi

doi:10.1267/ahc.18.375

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…2). This result is identical to the previous data (10). Control cells with no stimulation showed no cell aggregation.…”

Section: Cells Stimulated With Emlpsupporting

confidence: 92%

“…Control cells with no stimulation showed no cell aggregation. p-Benzoquinone (BQ) markedly inhibited the formation of reaction products, as reported previously (10).…”

Section: Cells Stimulated With Emlpsupporting

confidence: 80%

“…USA) at 37°C for 15 min and washed twice in HBSS by means of centrifugation at 150 X g for 10 min at 4°C, as described previously (10).…”

Section: Pretreatment Of the Cellsmentioning

confidence: 99%

“…Our previous cytochemical study showed N-formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated hydrogen peroxide (H2O2) production in guinea pig resident peritoneal macrophages (PM) and cell aggregation, and that H2O2 producing sites were essentially limited to plasma membranes where cells had contacted (10). Phorbol myristate acetate (PMA) and calcium ionophore (A23187) are also known to induce respiratory burst in macrophages (2,8).…”

mentioning

confidence: 99%

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Cytochemistry of plasma membranes activated by phorbol myristate acetate and calcium ionophore in the alveolar and peritoneal macrophages of guinea pigs.

Moriguchi

Hirai

1986

Acta Histochem. Cytochem

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“…2). This result is identical to the previous data (10). Control cells with no stimulation showed no cell aggregation.…”

Section: Cells Stimulated With Emlpsupporting

confidence: 92%

“…Control cells with no stimulation showed no cell aggregation. p-Benzoquinone (BQ) markedly inhibited the formation of reaction products, as reported previously (10).…”

Section: Cells Stimulated With Emlpsupporting

confidence: 80%

“…USA) at 37°C for 15 min and washed twice in HBSS by means of centrifugation at 150 X g for 10 min at 4°C, as described previously (10).…”

Section: Pretreatment Of the Cellsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Cytochemistry of plasma membranes activated by phorbol myristate acetate and calcium ionophore in the alveolar and peritoneal macrophages of guinea pigs.

Moriguchi

Hirai

1986

Acta Histochem. Cytochem

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“…as N-formyl-methionyl-leucyl-phenylalanine (11,12), concanavalin A and lectins (18), a two step stimulation mechanism (initial binding of stimulant to the membrane and secondary cell-cell adhesion) is needed for leukocytes to promote free radical production and that the NADPH oxidase, present at the unattached area of the plasma membrane, remains in the stand by state and is ready to produce radicals.…”

mentioning

confidence: 99%

Real time histochemistry of oxygen free radical production in human leukocytes.

Hirai

Moriguchi

Wang³

1992

Acta Histochem. Cytochem

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Cytochemical studies of hydrogen peroxide production in the tadpole tail ofRana japonica during metamorphic climax

et al. 1988

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The degeneration of tadpole tail tissue was investigated cytochemically by localizing the sites of hydrogen peroxide production. A cerium perhydroxide precipitation method was used. No reaction product was found in resting macrophages and intact muscle fibres during premetamorphosis. In the metamorphosis phase, extensive cerium precipitates were visualized on the outer surface of the plasma membrane of phagocytotic macrophages, fibroblasts, neutrophils, epidermal cells, muscle fibres, notochordal cells, nerve cells and capillary endothelial cells. The reaction products were localized on those parts of the plasma membranes of the macrophages that were in contact with those of adjoining cells. When catalase were added, the amount of deposits decreased. alpha-Tocopherol and indomethacin, but not dexamethasone, significantly inhibited the formation of the reaction products. These findings are taken to indicate that active oxygen is produced on the plasma membrane of activated macrophages and may play a role in the degeneration of the tail tissue.

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Hydrogen peroxide production stimulated by N-formyl-methionyl-leucyl-phenylalanine in guinea pig macrophages and effects of anti-inflammatory drugs and local anesthetics.

Cited by 3 publications

References 20 publications

Cytochemistry of plasma membranes activated by phorbol myristate acetate and calcium ionophore in the alveolar and peritoneal macrophages of guinea pigs.

Cytochemistry of plasma membranes activated by phorbol myristate acetate and calcium ionophore in the alveolar and peritoneal macrophages of guinea pigs.

Real time histochemistry of oxygen free radical production in human leukocytes.

Cytochemical studies of hydrogen peroxide production in the tadpole tail ofRana japonica during metamorphic climax

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