Hydrogen peroxide is a regulator of ABI1, a protein phosphatase 2C from <i>Arabidopsis</i>

Meinhard, Michael; Grill, Erwin

doi:10.1016/s0014-5793(01)03106-4

Cited by 186 publications

(116 citation statements)

References 64 publications

(88 reference statements)

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“…However, stomata of neither mutant closed in response to NO, indicating that the action of these two enzymes is downstream of NO synthesis. Both ABI1 and ABI2 can act as direct targets for in vitro modification by H 2 O 2 (27,28). However, whether or not these enzymes are also modified by NO, either in vitro or in vivo, remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana

Desikan

Griffiths

Hancock

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

625

505

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Section: Discussionmentioning

confidence: 99%

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana

Desikan

Griffiths

Hancock

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

625

505

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“…It has been reported that H 2 O 2 , whose production is activated by ABA, activates plasma membrane-bound Ca 2þ channels (Pei et al, 2000). Also, phosphatases generally contain active site sulfhydryl residues that are very sensitive to oxidation (Rhee et al, 2000), and both the ABI1 and ABI2 phosphatases have been reported to be inactivated by oxidation (Meinhard and Grill, 2001;Meinhard et al, 2002). The ABI1 and ABI2 phosphatases are also potential intermediaries in Ga protein signaling because Ga regulates phospholipase D activity, which in turn regulates the activity of the ABI-encoded phosphatases that negatively regulate signaling through the stress-activated MAPK kinase cascade (Zhang et al, 2004).…”

Section: Stress Signaling To Chloroplastsmentioning

confidence: 99%

Different Signaling and Cell Death Roles of Heterotrimeric G Protein α and β Subunits in the Arabidopsis Oxidative Stress Response to Ozone

et al. 2005

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Arabidopsis thaliana plants with null mutations in the genes encoding the a and b subunits of the single heterotrimeric G protein are less and more sensitive, respectively, to O 3 damage than wild-type Columbia-0 plants. The first peak of the bimodal oxidative burst elicited by O 3 in wild-type plants is almost entirely missing in both mutants. The late peak is normal in plants lacking the Gb protein but missing in plants lacking the Ga protein. Endogenous reactive oxygen species (ROS) are first detectable in chloroplasts of leaf epidermal guard cells. ROS production in adjacent cells is triggered by extracellular ROS signals produced by guard cell membrane-associated NADPH oxidases encoded by the AtrbohD and AtrbohF genes. The late, tissue damage-associated component of the oxidative burst requires only the Ga protein and arises from multiple cellular sources. The early component of the oxidative burst, arising primarily from chloroplasts, requires signaling through the heterotrimer (or the Gbg complex) and is separable from Ga-mediated activation of membrane-bound NADPH oxidases necessary for both intercellular signaling and cell death.

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“…An open question is whether ROS directly regulate Ca 21 -permeable channels and/or upstream modulators (Mori and Schroeder, 2004). In vitro biochemical studies revealed that H 2 O 2 directly inactivates the ABI1 and ABI2 type 2C protein phosphatase (PP2C) enzymes that function in ABA signaling (Meinhard and Grill, 2001;Meinhard et al, 2002). ABI1 and ABI2 function as negative regulators of ABA signaling (Merlot et al, 2001;Yoshida et al, 2006a).…”

Section: Ros and Aba Signalingmentioning

confidence: 99%

The Role of Reactive Oxygen Species in Hormonal Responses

Kwak

Nguyen²,

Schroeder³

2006

Plant Physiology

304

200

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Reactive oxygen species (ROS) are versatile molecules mediating a variety of cellular responses in plant cells, including programmed cell death (PCD), development, gravitropism, and hormone signaling. A picture showing how ROS function in signal transduction networks has started to emerge as the result of recent studies providing genetic, cell biological, and physiological evidence describing roles for ROS in signaling (Apel and Hirt, 2004;Laloi et al., 2004;Mittler et al., 2004;Mori and Schroeder, 2004). However, further efforts are necessary to characterize the targets and molecular functions of ROS, as well as the complex interplay of ROS-generating and ROSscavenging mechanisms. Moreover, the interactions of nitric oxide with other ROS species in hormone signaling is a subject of interest (Desikan et al., 2004;Wendehenne et al., 2004;Guo and Crawford, 2005;Bright et al., 2006). Due to limited space, in this Update article we focus on recent progress made in understanding the roles of ROS in hormone signaling. AUXIN, ETHYLENE, AND ROSROS have been implicated as second messengers in several plant hormone responses. Joo et al. (2001) showed that ROS are asymmetrically generated in roots by gravistimulation to regions of reduced growth. A function for ROS in root curvature was reported by inhibiting cell growth, thus contributing to tropisms. Auxin also induced ROS production in roots and the auxin transport inhibitor N-1-naphthylphthlamic acid did not inhibit hydrogen peroxide (H 2 O 2 )-induced root curvature, leading to the suggestion that ROS play a role downstream of transport in auxin signaling and gravitropism (Joo et al., 2001).A pharmacological study suggested that ethylene and ROS are required for root nodule initiation and function as positive transducers downstream of the Nod factor response in a semiaquatic legume (D'Haeze et al., 2003). Additional studies have suggested roles of ethylene in either stomatal opening or closing, depending on the plant species (Giulivo, 1986). Recently, it was reported that H 2 O 2 -mediated stomatal closure is completely disrupted in the loss-of-function mutant of the ethylene receptor etr1-7, suggesting a role for ETR1 in guard cell ROS signaling and stomatal closure (Desikan et al., 2005). Interestingly, in another recent study, ethylene was proposed to counteract stomatal closure (Tanaka et al., 2005). Abscisic acid (ABA)-induced stomatal closure was inhibited by ethylene or the hormone precursor 1-aminocyclopropane-1-carboxylic acid and by the ethylene-overproducing mutation eto1-1 (Tanaka et al., 2005). Moreover, this ethylene-induced inhibition of stomatal closure was suppressed in two ethylene-insensitive mutants, the dominant etr1-1 allele, and ein3-1 (Tanaka et al., 2005). Reverse transcription-PCR analysis with guard cellenriched epidermal strips showed that ETR1 is expressed in guard cells (Desikan et al., 2005). ATH1 and AG oligonucleotide-based (Affymetrix) microarray analyses of guard cell-expressed genes suggest that at least the ETR1, ERS1, and EIN4 eth...

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Hydrogen peroxide is a regulator of ABI1, a protein phosphatase 2C from Arabidopsis

Cited by 186 publications

References 64 publications

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana

Different Signaling and Cell Death Roles of Heterotrimeric G Protein α and β Subunits in the Arabidopsis Oxidative Stress Response to Ozone

The Role of Reactive Oxygen Species in Hormonal Responses

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