Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway

Zhang, Chao-Bin; Tang, Yichen; Xu, Xuejun; Guo, Shixiang; Wang, Huaizhi

doi:10.3892/etm.2015.2385

Cited by 37 publications

(32 citation statements)

References 20 publications

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“…Hydrogen therapy is protective against ischemic injury across a range of organs when administered as a gas or enriched solution (6)(7)(8)15). It is able to permeate the cellular wall and diffuse into the cytosol, mitochondria, and nucleus reducing hydroxyl radicals without affecting oxidation reduction reactions or levels of H 2 O 2 and NO (4).…”

Section: Discussionmentioning

confidence: 99%

“…Hydrogen has demonstrated a beneficial effect in all solid organs. Several rodent models have shown a beneficial effect in reducing acute and chronic transplant doi: 10.1111/aor.13118 related ischemic injury (6)(7)(8)(9)(10)(11)(12)(13). Nonetheless, there are few clinically relevant studies examining the effect of hydrogen on acute renal function and ischemia reperfusion injury (IRI).…”

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confidence: 99%

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Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model

et al. 2018

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In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival. Hydrogen has antioxidant and anti-inflammatory properties that can reduce the effects of ischemic injury. The aim of this study was to examine the effects of hydrogen gas administered during reperfusion in a preclinical model of kidney ischemia reperfusion injury. Porcine kidneys underwent 15 min of warm ischemia followed by 22 h of cold ischemia. They were then reperfused for 6 h with whole autologous blood on an ex vivo reperfusion circuit. Paired kidneys were randomized to control (n = 6) (25% oxygen, 5% carbon dioxide, 70% nitrogen) or hydrogen (n = 6) (2% hydrogen, 25% oxygen, 5% carbon dioxide, 68% nitrogen) groups. Tissue, urine, and blood samples were collected at baseline and hourly throughout the reperfusion period. Baseline measurements were similar across groups. Following perfusion, there was no significant difference between control and hydrogen groups in urine output (693 mL vs. 608 mL, P = 0.86), renal blood flow (105.9 vs. 108 mL/min/100g, P = 0.89), acid-base homeostasis, or creatinine clearance. There was a significant increase in cytokine levels from baseline to 6 h in both groups (IL-1β P = 0.002; IL-6 P = 0.004; IL-8 P = 0.002). However, there were no significant differences in levels of inflammatory cytokines (IL1β, IL-6, and IL-8) between the groups. The administration of hydrogen gas did not improve renal function, reduce oxidative damage, or inflammation during the reperfusion of ischemically damaged kidneys.

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Section: Discussionmentioning

confidence: 99%

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Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model

et al. 2018

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“…In 1975, Dole and colleagues reported in Science that hyperbaric hydrogen therapy (2.5% oxygen and 97.5% hydrogen under 8-atmospheric pressure) reduced the size of the squamous cell carcinoma tumors in hairless mice 45 . In 2007, Ohsawa and colleagues published a report in Nature Medicine that showed that inhalation of 1–4% hydrogen gas markedly reduced the size of cerebral infarction in rats, which ignited interest in the biomedical effect of molecular hydrogen in various diseases 46 , 47 . A large number of studies have reported that molecular hydrogen has significant protective effects on many neurological diseases, including neuropathic pain, cerebral injury, Alzheimer’s Disease, Parkinson’s Disease and so on 48 – 50 .…”

Section: Discussionmentioning

confidence: 99%

Molecular hydrogen increases resilience to stress in mice

Gao

Song

Wang

et al. 2017

Sci Rep

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The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. However, the potential role of molecular hydrogen in stress-related disorders is still poorly understood. The present study aims to investigate the effects of hydrogen gas on resilience to stress in mice. The results showed that repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice, assessed by tail suspension test (TST), forced swimming test (FST), novelty suppressed feeding (NSF) test, and open field test (OFT). ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-α in mice exposed to chronic mild stress. Finally, inhalation of hydrogen gas in adolescence significantly increased the resilience to acute stress in early adulthood, which illustrates the long-lasting effects of hydrogen on stress resilience in mice. This was likely mediated by inhibiting the hypothalamic-pituitary-adrenal axis and inflammatory responses to stress. These results warrant further exploration for developing molecular hydrogen as a novel strategy to prevent the occurrence of stress-related disorders.

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“…Since the hydrogen molecule is electrically neutral and considerably smaller than other antioxidants, it can easily penetrate membranes and enter organelles (12,26); however, it remains unclear exactly what type of oxidative stress is involved in femoral head necrosis. GSH stabilizes the lysosomal membranes to suppress injury to the vascular endothelium.…”

Section: A B a B Discussionmentioning

confidence: 99%

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model

Huang

Jiao

Yan

2015

Experimental and Therapeutic Medicine

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Abstract.A growing body of evidence suggests that hydrogen is a novel, selective antioxidant that exerts a protective effect against organ damage. The present study investigated the effect of hydrogen-rich saline on corticosteroid-induced necrosis of the femoral head in an animal model established using prednisolone. A total of 30 healthy, male, adult New Zealand white rabbits were randomly divided into two groups: Hydrogen-rich saline (treated with hydrogen-rich saline via intraperitoneal injection) and placebo (treated with normal saline). At the set time-points, the structure of the femoral head was examined using a microscope; the concentrations of glutathione (GSH), lipid peroxide (LPO), vascular endothelial growth factor (VEGF) and thrombomodulin (TM) in the plasma were measured and the microvessel density was quantified. The results showed that hydrogen-rich saline significantly decreased the levels of VEGF, TM and LPO and increased the GSH level in steroid-associated necrosis of the femoral head in the rabbit model. A significant increase in the microvessel density was observed in the hydrogen-rich saline group. Histopathological staining confirmed the results of the biochemical analysis. The present study demonstrates that hydrogen treatment may alleviate steroid-associated osteonecrosis by inhibiting oxidative stress. Hydrogen-rich saline may provide an alternative treatment for steroid-associated necrosis of the femoral head.

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Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway

Cited by 37 publications

References 20 publications

Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model

Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model

Molecular hydrogen increases resilience to stress in mice

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model

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