Molecular hydrogen increases resilience to stress in mice

Gao, Qiang; Song, Han Ho; Wang, Xiaoting; Liang, Ying; Xi, Yan-jie; Gao, Yuan; Guo, Qingjun; LeBaron, Tyler W.; Luo, Yunping; Li, Shuangcheng; Yin, Xi; Shi, Haishui; Ma, Yun‐Bao

doi:10.1038/s41598-017-10362-6

Cited by 37 publications

(30 citation statements)

References 55 publications

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“…Forced Swimming Test Forced swim test (FST) was modified from our previous reports. 21,31) A 20 cm diam-eter×35 cm high plastic cylinder was filled to a depth of 20 cm water (23-25°C). Mice were introduced into the water for a 6-min test session.…”

Section: Open Field Testmentioning

confidence: 99%

“…Tail Suspension Test Tail suspension test (TST) was performed following the existing protocol. 31,32) Mice were fixed by adhesive tape placed approximately 1 cm from the tip of the tail and were suspended 50 cm above the floor for a 6-min test session. The total time spent immobile in the last 4 min was recorded to reflect the depressive-like behavior.…”

Section: Open Field Testmentioning

confidence: 99%

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SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

Liang

et al. 2018

Biological & Pharmaceutical Bulletin

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SuHeXiang (SHX) has been used to treat a wide range of diseases, including those related to the central nervous system. However, the effects of SHX on mood disorders are still elusive. This study aimed to investigate the effects of SHX essential oil on stress-induced depression of mice. In an acute stress-induced depression model, mice inhaled vehicle (1% Tween 80) for 10 min or 10% SHX for 10 or 30 min once daily for 12 continuous days. In the chronic mild stress (CMS)-induced depression model, mice were exposed to a 28-d CMS treatment. Tail suspension test (TST), forced swimming test (FST), sucrose preference test (SPT), open field test (OFT), and novelty suppressed feeding (NSF) test were conducted. In addition, serum levels of angiogenin (ANG), thrombopoietin (TPO), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were evaluated by enzyme-linked immunosorbent assay (ELISA) assays. The results showed that in mice exposed to acute stress, repeated SHX inhalation exerted significant antidepressant and anxiolytic activities, and also reduced the serum levels of ANG, TPO, IL-6, and TNF-α. It also significantly reversed the depressive and anxiety-like behaviors, and reduced the serum levels of ANG and TPO in mice exposed to CMS. This is the first report to show that SHX inhalation could produce significant antidepressant and anxiolytic-like effects. These effects might be mediated by SHX ability to modulate the inflammatory response, and reduce dysfunction of vascular genesis and thrombosis. These results support further exploration for developing SHX inhalation as a novel therapeutic strategy for depression and stress-related disorders.

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Section: Open Field Testmentioning

confidence: 99%

Section: Open Field Testmentioning

confidence: 99%

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

Liang

et al. 2018

Biological & Pharmaceutical Bulletin

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“…Interestingly, some researchers also found that H 2 -rich water has neuron effects owing to its antioxidant properties. Although the deep mechanism is not clear, more and more researchers made an effort to study the biological function of H 2 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. To date, almost all H 2 gas production processes in the industry are based on natural gas, coal, petroleum, or water electrolysis.…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic Hydrogen Evolution via Water Splitting: A Short Review

et al. 2018

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Photocatalytic H2 generation via water splitting is increasingly gaining attention as a viable alternative for improving the performance of H2 production for solar energy conversion. Many methods were developed to enhance photocatalyst efficiency, primarily by modifying its morphology, crystallization, and electrical properties. Here, we summarize recent achievements in the synthesis and application of various photocatalysts. The rational design of novel photocatalysts was achieved using various strategies, and the applications of novel materials for H2 production are displayed herein. Meanwhile, the challenges and prospects for the future development of H2-producing photocatalysts are also summarized.

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“…Molecular hydrogen can readily permeate through biomembranes such as the blood-brain barrier, blood-testis barrier and placental barrier, thus benefiting hard-to-reach organs (e.g., brain) and organelles due to its low molecular mass, non-ionic state and hydrophobic properties. An increasing number of studies report that molecular hydrogen offers important neuroprotective benefits in depression, anxiety, neuropathic pain, Parkinson’s disease, cognitive impairment and brain injury via attenuating excessive inflammatory response and oxidative stress (Imai et al, 2016 ; Zhang et al, 2016 ; Gao et al, 2017 ; Iketani and Ohsawa, 2017 ; Wen et al, 2017 ). In mice, HRW consumption ad libitum prevented cognitive impairment with an associated suppression of the markers of oxidative stress, malondialdehyde and 4-hydroxy-2-nonenal, and reversed the suppression on neural proliferation of the hippocampus caused by chronic physical restraint (Nagata et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

“…Most recently, in CMS-treated mice (chronic mild stress) HRW exerted antidepressant-like effects by preventing oxidative stress, inflammation and apoptosis in the prefrontal cortex and hippocampus. Inhalation of molecular hydrogen could enhance resilience to acute and chronic stress in mice (Zhang et al, 2016 ; Gao et al, 2017 ). These results strongly suggest that molecular hydrogen administration may be a novel medical approach for many types of diseases, specifically those related to the central nervous system (Ohno et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

Guo

Yin

Qiao

et al. 2018

Front. Behav. Neurosci.

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Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administration on valproic acid (VPA)-induced autistic-like behavioral deficits, and the associated underlying mechanism in adolescent mice offspring. Pregnant ICR mice were randomly divided into five groups (n = 6). One group was injected with saline (NAV group) and provided hydrogen-free water. The other four groups were injected with VPA (600 mg/kg, intraperitoneally, i.p.) on pregnant day (PND) 12.5. One group was provided with hydrogen-free water (VEH group) and the other three groups were provided HRW at different segments, postnatal day 1 (PND 1) to PND 21 (PHV group), PND 13 to PND 21 (PVS group) or from PND 13 to postnatal day 42 (PVL group). Behavioral tests, including open field, novelty suppressed feeding (NSF), hot plate, social interaction (SI) and contextual fear memory tests were conducted between postnatal day 35–42. We found that HRW administration significantly reversed the autistic-like behaviors induced by maternal VPA exposure in the adolescent offspring of both male and female adolescent offspring. Furthermore, HRW administration significantly reversed the alternation of serum levels of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α), but without any effects on the BDNF levels in maternal VPA-exposed mice offspring. These data suggest the need for additional research on HRW as a potential preventive strategy for autism and related disorders.Lay Summary: Maternal VPA injection induces autistic-like behavioral deficits in adolescent mice offspring. HRW administration ameliorates autistic-like behavioral deficits. HRW administration reverses the alternation of serum levels of IL-6 and TNF-α induced by VPA.

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Molecular hydrogen increases resilience to stress in mice

Cited by 37 publications

References 55 publications

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

Photocatalytic Hydrogen Evolution via Water Splitting: A Short Review

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

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