Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota

Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition

“…15,20 In the current study, we provided the first evidence of the protective effects of HT against SLI, which is represented by reduced ALT and AST enzyme levels, 26 as well as the restored liver structure 27 after HT treatment. In consist, HT increased the levels of SOD and GSH and reduced excessive MDA levels in the livers of CUMS mice, thereby inhibiting the collapse of oxidative homeostasis in the liver 28 and preventing liver injury progression.…”

Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function

“…SCFAs provide energy for colon cells and play an important role in strengthening the integrity of the gut barrier. A recent study showed that the relative abundance of Prevotella was significantly decreased in acute alcoholic liver injury mice [46] . Also, decreased abundance of Ruminococcaceae and increased intestinal permeability were observed in actively drinking alcohol-dependent subjects [47] .…”

Patterns of the Nutrients and Metabolites in Apostichopus japonicus Fermented by Bacillus natto and Their Ability to Alleviate Acute Alcohol Intoxication

“…Singh and Sharma [21] found that the methanolic extract of Moringa oleifera leaves exhibited antioxidant activity and prevented early alcoholic liver injury by correcting oxidative stress. Hydrogen is an effective antioxidant for various diseases in animals and humans, and Liu et al [22] showed that inhaled hydrogen ameliorated alcohol-induced liver injury in a mouse model and attenuated hepatic oxidative stress, inflammation, and steatosis. Therefore, administering a novel functional food with high antioxidant capacity is important to intervene in liver injury caused by AAI.…”