Hydrogen Bond Formation as Basis For Radical Scavenging Activity: A Structure–Activity Study of C-Methylated Dihydrochalcones from Myrica gale and Structurally Related Acetophenones

Mathiesen, Liv; Malterud, Karl Egil; Sund, Reidar Bredo

doi:10.1016/s0891-5849(96)00277-8

Cited by 87 publications

(60 citation statements)

References 17 publications

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“…The constituents of M. nagi have been shown to inhibit toxicity in a number of animal model systems (Rastogi & Mehrotra, 1995;Chopra et al, 1996). A number of the chemical constituents of M. nagi have been identified as strong antioxidants (Malterud et al, 1996), and a number of pharmacological effects of M. nagi have been reported (Rastogi & Mehrotra, 1995;Chopra et al, 1996;Mathiesen et al, 1997). It is used as a remedy for various body disorders such as liver diseases, fever, asthma, anemia, chronic dysentery, ulcer, and inflammation (Nadkarni et.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Properties ofMyrica nagiBark Extract

Khan¹,

sagrawat²,

Upmanyu³

et al. 2008

Pharmaceutical Biology

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Myrica nagi Hook (syn. Myrica esculenta Buch. & Ham) (Myricaceae) is commonly known as box berry. The bark of Myrica nagi is used in the treatment of mental illness by different ethnic groups of the rural region of Orissa (India). In the present work, the anxiolytic and antidepressant effects of an ethanol extract of M. nagi were analyzed at three different dosages (100, 200, and 400 mg/kg, p.o.) by elevated plus-maze, light/dark exploration test, tail suspension test, and the forced swimming model. Oral administration of the ethanol extract (100, 200, and 400 mg/kg, p.o.) of M. nagi showed significant (p < 0.01) and dose-dependent anxiolytic activity by increasing time spent in the open arms of the elevated plus-maze and in the lit box indicating an anxiolytic effect. Nevertheless this treatment was unable to exhibit an effect identical to antidepressants in the tail suspension and forced swimming tests. Altogether, these results suggest an anxiolytic effect of the ethanol extract of M. nagi.

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Section: Introductionmentioning

confidence: 99%

Anxiolytic Properties ofMyrica nagiBark Extract

Khan¹,

sagrawat²,

Upmanyu³

et al. 2008

Pharmaceutical Biology

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“…When in the presence of substances capable of scavenging radicals, DPPH absorption is inhibited, leading to a stoichiometric discoloration in relation to the number of DPPH reduced molecules. The degree of discoloration is directly correlated with the radical scavenging activity of the evaluated substance 26 . For test our radical scavenging hypothesis, we performed DPPH assay in PbS-NP solutions.…”

Section: Radio-stabilizing Action Of Pbs-np In Pmmamentioning

confidence: 99%

Use of Lead (II) Sulfide Nanoparticles as Stabilizer for PMMA Exposed to Gamma Irradiation

et al. 2015

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Lead (II) sulfide (PbS) were synthesized by sonochemical method and crystals with cubic structure exhibit aggregated nanoparticles with size in the range of 50-100 nm. Commercial Poly(methyl methacrylate) (PMMA) containing the PbS nanoparticles (PbS-NP) exposed to gamma irradiation were investigated and both the viscosity-average molar mass (M v ) and degradation index (DI) values were measured. Ours results showed decreases in molar mass when the systems were gamma irradiated, i. e., random scission effects that take place in the main chain. On the other hand, DI results showed that the addition of PbS-NP at 0.3 wt% into the PMMA matrix decreased 100% the number of main chain scissions. Results about the free radical scavenger action of the PbS-NP were obtained by use of 2,2-diphenyl-1-(2,4,6-trinitrophenyl)-hydrazyl radical (DPPH) and are discussed in this study. Analysis of infrared spectra, refraction index, mechanical, and thermal properties showed influence of the PbS-NP in the physical behavior of PMMA.

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Section: Radiostabilizing Action Of St-np In Pmmamentioning

confidence: 99%

“…Probably, DPPH radical abstracts one electron from the sulfur of ST-NP and oxidizes it to the short-lived radical x . , which reacts with other DPPH molecule yielding the final nitro derivative of DPPH 26,27 (see Figure 4). Thus, we assumed the radical scavenging action to be the main role of ST-NP on the films of PMMA, but further work is required to a better understanding of the overall radiostabilizing process involving ST-NP in PMMA matrix.…”

Section: Radiostabilizing Action Of St-np In Pmmamentioning

confidence: 99%

Stibnite Nanoparticles as a New Stabilizer for Poly (Methyl Methacrylate) Exposed to Gamma Irradiation

et al. 2015

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Poly (methyl methacrylate), PMMA, may be used in manufacturing of devices, which are exposed to gamma irradiation. However, the polymer undergoes significant changes in its properties during process and the use of additives is a common form to stabilize the PMMA matrix. In this way, stibnite was synthesized by sonochemical method and the amorphous powder constituted of nanospheres was obtained and investigated as additive. Commercial PMMA containing stibnite nanoparticles (ST-NP) was investigated and the samples were irradiated with gamma radiation ( 60 Co). Our results showed that the addition of ST-NP at 0.3 wt% into the PMMA decreased the number of main chain scissions caused by the irradiation process, resulting in radiolytic stabilization of the polymer matrix. Analyses of mechanical properties showed influence of the ST-NP in the physical behavior of PMMA. Our findings suggest that stibnite nanoparticles are an effective additive for PMMA used in application of radiation resistance.

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Hydrogen Bond Formation as Basis For Radical Scavenging Activity: A Structure–Activity Study of C-Methylated Dihydrochalcones from Myrica gale and Structurally Related Acetophenones

Cited by 87 publications

References 17 publications

Anxiolytic Properties ofMyrica nagiBark Extract

Anxiolytic Properties ofMyrica nagiBark Extract

Use of Lead (II) Sulfide Nanoparticles as Stabilizer for PMMA Exposed to Gamma Irradiation

Stibnite Nanoparticles as a New Stabilizer for Poly (Methyl Methacrylate) Exposed to Gamma Irradiation

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