Hydrogels in endovascular embolization

Horák, Daniel; Švec, František; Kálal, J.; Adamyan, A. A.; Skuba, N. D.; Titova, Mariya; Dan, V N; Varava, B N; Trostenyuk, Nadezhda; Воронкова, О. С.; Гумаргалиева, К. З.; Timochina, Valeriya

doi:10.1016/0142-9612(88)90035-x

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…5,7 On the other hand, the hydrogels in a water while maintaining a distinct three-dimenspherical microparticle form (microspheres or sional structure (insoluble). The preparation of beads) are used in hemoperfusion, 8 enzyme impoly(2-hydroxyethyl methacrylate) (PHEMA) mobilization, 9,10 endovascular occlusion, 11 and hydrogels is a subject of great interest, especially also in controlled drug release. 5,12 -13 They have for biomedical and pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Curing kinetics of the synthesis of poly(2-hydroxyethyl methacrylate) (PHEMA) with ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent

Huang

Sun

Huang

1997

J. Polym. Sci. A Polym. Chem.

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Section: Introductionmentioning

confidence: 99%

Curing kinetics of the synthesis of poly(2-hydroxyethyl methacrylate) (PHEMA) with ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent

Huang

Sun

Huang

1997

J. Polym. Sci. A Polym. Chem.

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“…In terms of safety for its transportation and its use at remote sites, HEMA has low flammability and reactivity, but must be handled with gloves to avoid contact with skin. Oligomerized HEMA is considered nontoxic [25]; thus, the use of pre-oligomerized HEMA as a component of the derivatization materials (rather than employing in situ oligomerization) would improve safety. In conclusion, preparation of LLINs based on in situ oligomerization or adsorption of pre-oligomerized HEMA for the long-term retention of pyrethroid molecules may be a useful tool in the worldwide effort to control malaria, and may be an effective means to prepare other textiles that provide insect protection e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The initial hypothesis employed for forming LLINs was that in situ oligomerization of water-soluble monomers would be required to sufficiently retain pyrethroid; thus, conditions required for oligomerization were sought. In addition to water solubility, HEMA and PEG-acrylate were selected as monomers due to the low toxicity of the polymers they form [25,26]. The formation of insoluble polymer, as observed visually, was used as a criterion to determine the reaction conditions required for in situ oligomerization in aqueous solution.…”

Section: Conditions Required For Oligomerizationmentioning

confidence: 99%

Simple and Inexpensive Preparation of Long-lasting Insecticidal Nets Via Co-adsorption of Pyrethroid and Oligomer

Zhuang

Chittur

Hayes

et al. 2008

Textile Research Journal

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Insecticide-treated bed nets, or Long-Lasting Insecticidal Nets (LLINs), are valuable tools in the effort to control mosquitoes ( Anopheles gambiae ), the carriers of the malaria parasite, in Africa. Insecticide (pyrethroid) is retained by LLINs when subjected to washing, which allows for their long-term effectiveness. A simple and inexpensive method for preparing LLINs based upon the co-adsorption of the pyrethroid deltamethrin and oligomer or monomer when commercial nets are dipped in aqueous solution is described here. An aqueous solution of monomer, 2-hydroxy ethyl methacrylate, or its oligomers, was first prepared. The net was soaked in the aqueous solution for a few minutes, then subjected to the removal of its excess water. The majority of experiments involved in situ oligomerization by exposing the treated net to sunlight and warm ambient temperatures. LLINs synthesized in the laboratory as such retained 70— 90 % of their ability to kill mosquitoes after six successive washes and 70 % of their original deltamethrin content, both benchmarks of which were comparable to the performance of 1st generation commercial LLIN products. A cost analysis indicated that chemicals required for the derivatization solution would cost only an additional 1.15 USD beyond that of the pyrethroid. The approach developed here to prepare LLINs from local or selected sources of bed nets and insecticide agents allows for their preparation in remote settings, would reduce costs, and simplify the transportation and distribution compared to employing commercial LLINs prepared abroad, and may also be valuable for modifying military, agricultural, and outdoor sports textiles.

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“…Reports of the research and development of radiopaque embolization beads using organoiodine compounds appeared as early as the 1980s 73 , 74 , 75 , 76 , 77 , 78 . Poly(2-hydroxyethymethacrylate) was among the first hydrogels used in the research.…”

Section: Radiopaque Nanoparticles and Biomaterials For Atherosclerosimentioning

confidence: 99%

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Tian

Feng

et al. 2018

Acta Pharmaceutica Sinica B

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A review of radiopaque nano and polymeric materials for atherosclerosis imaging and catheterization procedures is presented in this paper. Cardiovascular diseases (CVDs) are the leading cause of death in the US with atherosclerosis as a significant contributor for mortality and morbidity. In this review paper, we discussed the physics of radiopacity and X-ray/CT, clinically used contrast agents, and the recent progress in the development of radiopaque imaging agents and devices for the diagnosis and treatment of CVDs. We focused on radiopaque imaging agents for atherosclerosis, radiopaque embolic agents and drug eluting beads, and other radiopaque medical devices related to catheterization procedures to treat CVDs. Common strategies of introducing radiopacity in the polymers, together with examples of their applications in imaging and medical devices, are also presented.

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Hydrogels in endovascular embolization

Cited by 13 publications

References 5 publications

Curing kinetics of the synthesis of poly(2-hydroxyethyl methacrylate) (PHEMA) with ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent

Curing kinetics of the synthesis of poly(2-hydroxyethyl methacrylate) (PHEMA) with ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent

Simple and Inexpensive Preparation of Long-lasting Insecticidal Nets Via Co-adsorption of Pyrethroid and Oligomer

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

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