Hydrogels in Electrophoresis: Applications and Advances

Liu, Chenchen; Kubo, Takuya; Otsuka, Koji

doi:10.2116/analsci.20r004

Cited by 5 publications

(1 citation statement)

References 105 publications

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“…The use of paper and hydrogel in combination has been found to be effective in separation techniques, particularly in electrophoresis and LFAs. Hydrogels offer the ability to regulate flow for distinct separation bands, adjust pore sizes to suit various sample types, and decrease non-specific absorption [125][126][127].…”

Section: Biomolecules Separationmentioning

confidence: 99%

Extended functionalities of paper-based analytical devices using hydrogels for biomedical applications

Mahardika,

Kin,

Kwon

et al. 2023

Flex. Print. Electron.

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Paper-based analytical devices are a strong candidate for development due to the global need for accurate, easy-to-use, and cost-effective tools. Paper offers potential as a substrate for biomedical diagnostic devices, but on its own it is limited in versatility. By combining paper with hydrogel, researchers are able to improve automation, sensitivity, affordability, flexibility, and speed. Hydrogel, a highly biocompatible material, enhances fluid flow control and the biocompatibility of paper for functional interaction with biomolecules. Hydrogel-coated paper has been utilized for various applications, including separation and detection, microfluidics, and cell culture. Here we summarize the paper-based analytical tools with hydrogel incorporated into the paper substrate for biomedical purposes. The use of hydrogel-coated paper offers new opportunities for advanced analytical tools with improved sensitivity and functionality.

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Section: Biomolecules Separationmentioning

confidence: 99%