Hydrogels for Therapeutic Delivery: Current Developments and Future Directions

Buwalda, Sytze J.; Vermonden, Tina; Hennink, Wim E.

doi:10.1021/acs.biomac.6b01604

Cited by 365 publications

(262 citation statements)

References 122 publications

Supporting

Mentioning

251

Contrasting

Unclassified

Order By: Relevance

“…Research activity on the development of similar systems is continuing with a fast pace as it is clearly demonstrated by several excellent reviews and perspectives [48][49][50][51][52][53] dealing with drug delivery systems which are analogous to the present review. …”

Section: Concluding Remarks and Outlookmentioning

confidence: 99%

Drug Delivery Systems Based on Hydroxyethyl Starch

2017

View full text Add to dashboard Cite

The advantageous biological properties of hydroxyethyl starch (HES) triggered research interest toward the design and synthesis of drug delivery systems (DDSs) based on this polysaccharide. Convenient reaction schemes, including one-step reactions, led to the synthesis of HES conjugates with selected anticancer molecules or therapeutic proteins. Nanocapsules and hydrogels based on HES were also prepared and studied as prospective drug delivery systems. Formulations originating from these drug conjugates and also from nanocapsules and hydrogels loaded with drugs were characterized, highlighting the extension of their half-life in plasma, which is a critical property as far as their efficacy is concerned. Results obtained in vitro and in vivo proved promising, justifying the undertaking of additional experiments with such systems, including their multifunctionalization. The promising formulations that are discussed in this Topical Review is expected to further increase interest in applying HES for molecular constructing novel DDSs with enhanced efficacy, which may, in the future, find clinical applications.

show abstract

Section: Concluding Remarks and Outlookmentioning

confidence: 99%

Drug Delivery Systems Based on Hydroxyethyl Starch

2017

View full text Add to dashboard Cite

show abstract

“…In the past several decades, there have been numerous hydrogel systems that comply with the conditions for ophthalmic drug delivery. [2,5,[29][30][31] Ophthalmic hydrogel formations can be obtained by several mechanisms including covalent crosslinking, pH-, temperature-, and ionic-trigger systems.…”

Section: Ophthalmic Hydrogel Systemmentioning

confidence: 99%

Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery

Lin

Lei

Shi

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

Blindness and vision impairment are major global health problems. Effective ophthalmic drug delivery poses a significant challenge because of protective physiological barriers and various biological clearance mechanisms that result in extremely low ocular bioavailability. Over the past several decades, several safe and effective ophthalmic drug delivery approaches have been promoted to combat these problems and to improve ocular bioavailability. Among these approaches, the stimulus‐responsive hydrogel for topical drug delivery has gained increasing attention because of its prolonged drug retention at the local site and enhanced ocular bioavailability. This review summarizes and presents recent advances and perspectives of a stimulus‐responsive hydrogel for ophthalmic drug delivery.

show abstract

“…Furthermore, the cell adhesive property of the injectable hydrogels can be modulated by the covalent conjugation of cell adhesion ligands to the hydrogel precursor . Nevertheless, the release of small molecular drugs or bioactive factors from injectable hydrogels is rapid and completed within a few days due to the rapid diffusion, which represents a major limitation of injectable hydrogels in the clinical settings . Therefore, injectable hydrogels that can locally retain bioactive factors for a prolonged period and deliver them in a sustained manner would be useful for tissue regeneration .…”

Section: Introductionmentioning

confidence: 99%

Tunable Engineering of Heparinized Injectable Hydrogels for Affinity‐Based Sustained Delivery of Bioactive Factors

Kim

Thambi

Lym

et al. 2019

Macro Materials & Eng

View full text Add to dashboard Cite

Here, the design of an in situ‐forming injectable hydrogel is reported based on pH‐ and temperature‐responsive copolymers finely engineered with heparin for the sustained delivery of bioactive factors. In order to develop such heparinized injectable hydrogels, pH‐ and temperature‐responsive copolymers based on poly(ethylene glycol) and poly(urethane sulfamethazine) (PEG‐PUSSM) are synthesized and acrylated, and subsequently coupled with thiolated heparin through Michael‐addition reaction. The content of heparin in the bioconjugates (Hep‐PUSSM) is finely tuned to control the release of heparin‐binding bioactive factors. The free‐flowing bioconjugate sols at room temperature transform to stable viscoelastic gel in physiological conditions, indicating that heparin modification does not affect the sol–gel transition. The subcutaneous administration of bioconjugate sols to the dorsal‐region of Sprague‐Dawley rats forms a hydrogel depot and shows controlled degradation. The bioconjugates effectively bind with bioactive factors (VEGF) through simple mixing, and the release is controlled over a period of 4 weeks without an initial burst. As a result, the implantation of VEGF‐loaded bioconjugate gel induces angiogenesis throughout the hydrogel network. The tunable engineering of the injectable hydrogel by heparinization with independent controllable physical properties sustains the release of bioactive factors, indicating that it may be a promising platform for the delivery of bioactive factors.

show abstract

Hydrogels for Therapeutic Delivery: Current Developments and Future Directions

Cited by 365 publications

References 122 publications

Drug Delivery Systems Based on Hydroxyethyl Starch

Drug Delivery Systems Based on Hydroxyethyl Starch

Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery

Tunable Engineering of Heparinized Injectable Hydrogels for Affinity‐Based Sustained Delivery of Bioactive Factors

Contact Info

Product

Resources

About